U.S. Department of Health and Human Services
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Division of Digestive Diseases & Nutrition (DDN)

Director DDN, Stephen JamesDirector​
Dr. Stephen James

Deputy Director, DDN Dr. Jay HoofnagleDeputy Director
Dr. Jay Hoofnagle​

About the Division

The Division of Digestive Diseases and Nutrition (DDN) supports research related to digestive diseases, including the alimentary tract, liver and pancreas, nutrition and obesity. The programs include basic, translational and clinical research, research training, and career development. DDN also promotes public awareness and education about digestive diseases and related conditions, and oversees several national public awareness campaigns.​

​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​Division Staff

View staff and contact information.

Additional Information 


 Research Programs

The Division of Digestive Diseases and Nutrition (DDN)  supports basic, translational and clinical research in:

 For a list of all NIDDK programs, including theses, visit Research Programs and Contacts.​​


 Funding Opportunities

Posted DateTitleFull Announcement
11/14/2014Administrative Supplements for Research on Sex/Gender Differences (Admin Supp) (Summary) PA-15-034
10/31/2014Research on Eosinophil Associated Disorders (R01) (Summary) PA-15-027
10/31/2014Research on Eosinophil Associated Disorders (R21) (Summary) PA-15-028
10/9/2014Studies of HIV in Digestive Diseases Limited to Gastrointestinal Mucosal Immunology and Liver Diseases (Summary) RFA-DK-14-019
7/30/2014NIDDK Central Repositories Non-renewable Sample Access (X01) (Summary) PAR-14-301
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/4/2014Research on Chronic Overlapping Pain Conditions (R01) (Summary) PA-14-244
4/22/2014Predoctoral Training in Biomedical Big Data Science (T32) (Summary) RFA-HG-14-004
4/22/2014Revisions to Add Biomedical Big Data Training to Active Institutional Training Grants (T32) (Summary) RFA-HG-14-005
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) (Summary) PA-14-149
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30) (Summary) PA-14-150
1/30/2014Change of Grantee Organization (Type 7 Parent) (Summary) PA-14-078
1/17/2014PHS 2014-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) (Summary) PA-14-071
1/17/2014PHS 2014-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) (Summary) PA-14-072
1/16/2014Courses for Skills Development in Biomedical Big Data Science (R25) (Summary) RFA-HG-14-008
1/16/2014Open Educational Resources for Biomedical Big Data (R25) (Summary) RFA-HG-14-009
1/15/2014Mentored Career Development Award in Biomedical Big Data Science for Clinicians and Doctorally Prepared Scientists (K01) (Summary) RFA-HG-14-007
1/2/2014Lead Optimization and Pre-Clinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R43/R44) (Summary) PA-14-055
1/2/2014Genetic Susceptibility & Variability of Human Structural Birth Defects (R01) (Summary) PA-14-056
12/19/2013NIH Pathway to Independence Award (Parent K99/R00) (Summary) PA-14-042
12/19/2013Mentored Clinical Scientist Research Career Development Award (Parent K08) (Summary) PA-14-046
12/19/2013Midcareer Investigator Award in Patient-Oriented Research (Parent K24) (Summary) PA-14-047
12/19/2013Mentored Quantitative Research Development Award (Parent K25) (Summary) PA-14-048
12/19/2013Mentored Patient-Oriented Research Career Development Award (Parent K23) (Summary) PA-14-049
12/18/2013Centers for AIDS Research and Developmental Centers for AIDS Research (P30) (Summary) PAR-14-041
12/11/2013Chronic Condition Self-Management in Children and Adolescents (R01) (Summary) PA-14-029
12/6/2013Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) (Summary) PA-14-015
12/6/2013Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35) (Summary) PA-14-016
11/21/2013Seeding Collaborations for Translational Research to Discover and Develop New Therapies for Diseases and Conditions within NIDDK's Mission (Revisions) (R01) (Summary) PAR-14-006
10/24/2013Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (Admin Supp) (Summary) PA-13-381
9/20/2013Opportunities for Collaborative Research at the NIH Clinical Center (U01) (Summary) PAR-13-358
9/11/2013Academic Research Enhancement Award (Parent R15) (Summary) PA-13-313
9/11/2013NIH Support for Conferences and Scientific Meetings (Parent R13/U13) (Summary) PA-13-347
8/13/2013Health Promotion Among Racial and Ethnic Minority Males (R01) (Summary) PA-13-328
8/2/2013Gut Microbiota-Derived Factors in the Integrated Physiology and Pathophysiology of Diseases within NIDDK's Mission (R01) (Summary) PAR-13-293
8/2/2013Collaborative Interdisciplinary Team Science in NIDDK Research Areas (R24) (Summary) PAR-13-305
8/2/2013Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R01) (Summary) PA-13-292
8/2/2013Research Project Grant (Parent R01) (Summary) PA-13-302
7/26/2013Systemic Amyloidosis: Basic, Translational, and Clinical Research (R01) (Summary) PA-13-286
7/8/2013NIDDK Program Projects (P01) (Summary) PAR-13-266
7/8/2013NIDDK Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34) (Summary) PAR-13-268
5/22/2013Phenotyping Embryonic Lethal Knockout Mice (R01) (Summary) PAR-13-231
5/15/2013Biomarkers for Diabetes, Digestive, Kidney and Urologic Diseases Using Biosamples from the NIDDK Repository (R01) (Summary) PAR-13-228
4/5/2013Addressing Health Disparities in NIDDK Diseases (R01) (Summary) PA-13-183
3/1/2013Understanding and Promoting Health Literacy (R01) (Summary) PAR-13-130
2/15/2013Mechanisms, Models, Measurement, & Management in Pain Research (R01) (Summary) PA-13-118
2/11/2013Improvement of Animal Models for Stem Cell-Based Regenerative Medicine (R01) (Summary) PAR-13-114
1/9/2013Dissemination and Implementation Research in Health (R01) (Summary) PAR-13-055
1/7/2013Small Grants for New Investigators to Promote Diversity in Health-Related Research (R03) (Summary) PAR-13-074
12/21/2012Ancillary Studies to the NIDDK Intestinal Stem Cell Consortium (R01) (Summary) PAR-13-066
10/10/2012Early-Stage Pharmacological Validation of Novel Targets and Accompanying Pre-Therapeutic Leads for Diseases of Interest to the NIDDK (R01) (Summary) PAR-13-007
9/14/2012Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03) (Summary) PAR-12-285
8/17/2012Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (Summary) PAR-12-265
8/8/2012New Technologies for the Study of Lymphatics in the Digestive and Urinary Systems (R43/R44) (Summary) PA-12-258
8/8/2012Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01) (Summary) PAR-12-259
4/24/2012Multidisciplinary Studies of HIV/AIDS and Aging (R01) (Summary) PAR-12-175
4/6/2012Research Supplements to Promote Diversity in Health-Related Research (Admin Supp) (Summary) PA-12-149
4/6/2012Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp) (Summary) PA-12-150
3/23/2012Pilot and Feasibility Clinical Research Studies in Digestive Diseases and Nutrition (R21) (Summary) PA-12-139
3/19/2012Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21) (Summary) PA-12-125
12/1/2011NIDDK Education Program Grants (R25) (Summary) PAR-12-047
10/7/2011Collaborations with National Centers for Biomedical Computing (R01) (Summary) PAR-12-001
View Additional Funding Opportunities


 Strategic Plans and Reports By Disease

Report NameDescription
NIDDK Recent Advances & Emerging Opportunities 2014A compendium highlighting examples of the many research advances published by NIDDK-funded scientists and their colleagues in fiscal year 2013.
NIDDK Recent Advances & Emerging Opportunities 2013Highlights research advances by NIDDK-supported scientists and the technologies that made them possible
NIH Strategic Plan on Minority Health DisparitiesEstablishes proposed health disparities research priorities, objectives, and activities; includes an estimated budget by IC of the; and describes the means for achieving stated objectives, and the dates objectives are expected to be achieved
Strategic Plan for NIH Obesity ResearchOutlines a guide to accelerate a broad spectrum of research toward developing new and more effective approaches to address the tremendous burden of obesity, so that people can look forward to healthier lives
NIDDK: 60 Years of Advancing Research to Improve HealthCelebrates the Institute’s accomplishments over the past 60 years in supporting and conducting research on common, chronic, and costly diseases affecting people in this country and around the world
Opportunities & Challenges in Digestive Diseases Research: Recommendations of the National Commission on Digestive DiseasesDescribes recent research advances and identifies research goals to be pursued by the National Institutes of Health (NIH) and the digestive diseases research community over the next decade
The Burden of Digestive Diseases in the United StatesProvides current and retrospective data on all aspects of the epidemiology, practice patterns, costs, and impact of digestive diseases in the United States
A Progress Report on NIDDK Efforts To Promote Translational ResearchDescribes the efforts of the NIDDK to promote the translation of fundamental discoveries from the laboratory bench of basic scientists into investigations in the clinic, which promise to directly benefit patients
Action Plan for Liver Disease ResearchAddresses the burden of liver diseases in the United States and provides a 10-year Action Plan for Liver Disease Research
Conquering Diabetes: A Strategic Plan for the 21st CenturyIncludes recommendations for future diabetes research directions and corresponding overall budget estimates for implementing the proposed new research initiatives and was developed by the Diabetes Research Working Group
View All Strategic Plans