U.S. Department of Health and Human Services
Corinne Silva
 

 Contact Info

 
Tel: 301-451-7335
Email: silvacm@mail.nih.gov
 

 Select Experience

 
  • Assistant/Associate ProfessorDepartments of Medicine and Microbiology, University of Virginia2000-2009
  • Research Assistant ProfessorUniversity of Virginia1993-2000
  • Postdoctoral FellowshipUniversity of Virginia1989-1993
  • Ph.D.University of North Carolina, Chapel Hill1989

Current Responsibilities and Activities

I administer two research grant portfolios, one on signaling and nutrient sensing, which is aimed at elucidating signaling pathways that regulate cellular responses to insulin and other hormones/factors or that reveal the role of nutrient sensing signaling pathways in the development and/or progression of insulin resistance, type 2 diabetes, obesity, and metabolic diseases.  Studies involve the identification of regulators, interacting partners, and substrates to elucidate modes of signal transmission, including circadian regulation, that impact physiological systems and result in metabolic dysfunction.

The other portfolio focuses on the role of the intrauterine environment in metabolic disease of the offspring.  The Obesity, Pregnancy, and the Intrauterine Environment program includes both basic and translational studies that investigate the mechanisms by which the intrauterine environment alters metabolic responses in the offspring.  A particular focus is on the role maternal diet plays in the development of pathophysiological consequences in offspring, including obesity and type 2 diabetes.  Research in this area is aimed at elucidating the signals that mediate these long-term effects including, but not limited to, intracellular signaling pathways, inflammatory cytokines, nutrient sensing pathways, and epigenetic imprinting.  The ultimate goal is to identify molecular targets that could be therapeutically altered to prevent or alleviate obesity and type 2 diabetes.

In addition to the portfolios, I oversee the Nuclear Receptor Signaling Atlas Consortium.

​Research Programs

Endocrinology and Hormone Signaling
The Endocrinology and Hormone Signaling program supports basic and clinical research on neuroendocrinology, the HPA axis, bone metabolism, mechanisms of nuclear receptor signaling, and signaling pathways involved in nutrient sensing at target tissues

Metabolism, Energy Balance, and Obesity
This program supports research on metabolism, energy balance, and obesity

Obesity, Pregnancy, and the Intrauterine Environment
This program supports basic and clinical research to understand the effects of over-nutrition, obesity, and diabetes on pregnant women and the metabolic health of their offspring

Pathophysiology of Diabetes and Metabolic Disease
This program supports basic and clinical research that addresses the pathophysiology of metabolic diseases, including the etiology of type 1 diabetes and other autoimmune endocrine diseases

Current Committee Memberships

  • Staff Training in Extramural ProgramsMember
  • Large Grants CommitteeChair
  • National Center for Sleep Disorders Research CommitteeMember
  • Obesity Research Working GroupMember