U.S. Department of Health and Human Services
Lisa Spain

 Contact Info

Tel: 301-451-9871
Email: spainl@mail.nih.gov

 Select Experience

  • Scientist II Holland Laboratories for Biomedical Sciences, American Red Cross, George Washington University Medical School1999-2004
  • Assistant ProfessorWistar Institute, University of Pennsylvania1993-1999
  • Postdoctoral FellowDepartment of Cellular and Molecular Biology, Harvard University1991-1993
  • Adjunct Associate ProfessorGeorge Washington School Of Medicine2000-2004
  • Ph.D.Massachusetts Institute of Technology1990

Lisa M. Spain, Ph.D.

Program Director, Division of Diabetes, Endocrinology, and Metabolic Diseases

Current Responsibilities & Activities

I serve as director of the Immunobiology of Type 1 Diabetes and Autoimmune Endocrine Diseases Program.  My portfolio includes basic and clinical research on the pathogenic mechanisms of autoimmunity in type 1 diabetes and autoimmune thyroid diseases.

I am the Project Scientist for Type 1 Diabetes TrialNet—an international consortium for the conduct of clinical trials for the prevention and reversal of type 1 diabetes.  My special interest is in facilitating biomarker discovery.

I am the Program Director for The Environmental Determinants of Diabetes in Youth (TEDDY), an international consortium of scientists studying a cohort of over 8,000 children with genetic risk for type 1 diabetes. The TEDDY study follows the children from birth to age 15, and collects data on their environmental exposures, including diet, infections, psychosocial factors, microbiome, and metabolome, etc. with respect to autoimmunity and progression to disease.

​Research Programs

Clinical Research in Type 1 Diabetes
This program supports clinical research that addresses the determinants, etiology, progression, prevention, and treatment of type 1 diabetes in children and adults

Pathophysiology of Diabetes and Metabolic Disease
This program supports basic and clinical research that addresses the pathophysiology of metabolic diseases, including the etiology of type 1 diabetes and other autoimmune endocrine diseases

Current Committee Memberships

  • The Biomarkers Consortium: Inflammation & Immunity Steering CommitteeNIDDK Representative
  • NIH Autoimmune Disease Coordinating CommitteeNIDDK Representative
  • NIDDK Clinical Sciences Working GroupMember
  • NIDDK/DEM Autoimmunity/Transplantation Working GroupMember