U.S. Department of Health and Human Services
Michael Appel

 Contact Info

Tel: 301-594-4740
Email: appelm@mail.nih.gov

 Select Experience

  • Associate ProfessorDepartments of Pathology and Medicine, University of Massachusetts Medical School1999-2004
  • Senior Clinical ScientistCOBE BCT, Inc.1994-1999
  • Principal ScientistCytotherapeutics, Inc.1991-1993
  • Postdoctoral StudyAssociate Professor, Department of Pathology, University of Massachusetts Medical School1976-1991
  • Ph.D.University of Minnesota1976

Michael C. Appel, Ph.D.

Program Director, Division of Diabetes, Endocrinology, and Metabolic Diseases

Current Responsibilities and Activities

I direct programs studying islet biology and transplantation research.  My duties include management of a research portfolio that covers studies to optimize islet yield, viability, and durability in the procurement and pretransplant process; applications of islet immune-isolation techniques and manipulations enhancing islet graft survival and immune tolerance; evaluation of novel immunosuppressive reagents, regimens, or adjunct therapeutics that promote islet graft survival; and mechanistic studies that specifically contribute to understanding integrated islet function, beta cell renewal, and pathophysiology.

In addition, I serve as a scientific officer for the NIDDK in coordination of research activities with the National Institute of Allergy and Infectious Diseases for the Non-Human Primate Immune Tolerance Cooperative Study Group.  I also serve as the scientific officer for the Integrated Islet Distribution Program and the Collaborative Islet Transplantation Registry.

​Research Programs

Endocrine Pancreas
The Endocrine Pancreas program supports research on the basic biology, development, and function of the endocrine pancreas as well as clinical studies on islet transplantation for the treatment of type 1 diabetes

Current Committee Memberships

  • Beta Cell Biology, Type 2 Diabetes, and Autoimmunity and Transplantation Working GroupsMember
  • Network for Pancreatic Organ Donors with DiabetesExecutive Advisory Committee
  • Minority Affairs Advisory GroupMember
  • Human Tissue Procurement for ResearchNIDDK Representative