U.S. Department of Health and Human Services
Michael Flessner
 

 Contact Info

 
Tel: 301-451-4901
Email: flessnermf@mail.nih.gov
 

 Select Experience

 
  • Assistant/Associate Professor of MedicineBiophysics, and Physiology, University of Rochester School of Medicine and Dentistry1991-2001
  • Fellowship/Research AssociateLaboratory of Kidney and Electrolyte Metabolism, NHLBI, NIH1988-1991
  • Professor and John D. Bower Chair of Nephrology and HypertensionUniversity of Mississippi Medical Center2001-2010
  • M.D.University of Maryland1985
  • Ph.D. University of Michigan1981

Michael Flessner, M.D., Ph.D.

Program Director, Division of Kidney, Urologic, and Hematologic Diseases

Current Responsibilities and Activities

My current responsibilities as director of the Kidney Inflammation and Inflammatory Diseases program include management of a diverse research portfolio.  This research includes HALT-PKD (clinical trials of treatments to slow loss of kidney function related to polycystic kidney disease, or PKD); CRISP (radiologic imaging research to improve the detection and monitoring of PKD progression); and the Interdisciplinary Centers for PKD Research.  In 2013 I formed two new consortiums:  the Chronic Kidney Disease (CKD) Pilot Trials Consortium, comprising four centers and a data coordinating center (DCC) that will test new CKD therapies for dosing and safety; and the Glomerulonephritis Consortium, involving four centers and a DCC that will carry out a longitudinal study of four types of glomerulonephritis.

In addition, I am the project scientist for two Common Fund projects:  the TIME trial—a pragmatic clinical trial in dialysis patients and part of the Health Care Systems Collaboratory; and the renal microphysiological system, which is an in vitro bioengineering method of testing drugs and toxins to simulate human conditions.  I also am responsible for managing research on other inflammatory renal diseases, including lupus nephritis and diabetic nephropathy, renal transplantation, and chronic kidney disease.

​Research Programs

Chronic Kidney Disease
The NIDDK Chronic Kidney Disease program supports basic, translational, and clinical research on the mechanisms and pathophysiology underlying renal disease and its progression

Diabetic Kidney Disease
The NIDDK Diabetic Kidney Disease program supports basic, translational, and clinical research on the mechanisms and pathophysiology underlying diabetic nephropathy and its progression

End-Stage Renal Disease
The NIDDK End-Stage Renal Disease (ESRD) program supports basic, translational, and clinical research on the mechanisms and pathophysiology of kidney failure and the progression of chronic kidney disease leading to kidney failure

Kidney Clinical Research and Epidemiology
The NIDDK Kidney Clinical Research and Epidemiology program advances clinical studies and epidemiologic research on renal disease

Kidney Disease Centers
The NIDDK Kidney Disease Centers enhance and extend the effectiveness of research related to nephrology by encouraging collaboration among investigators from relevant disciplines

Kidney Inflammation and Inflammatory Diseases
An NIDDK program that advances research on both normal and pathologic renal processes involving immune- or inflammatory-mediated mechanisms

Polycystic Kidney Disease
The NIDDK Polycystic Kidney Disease (PKD) program supports basic, translational, and clinical research relating to renal injury from cyst growth that occurs in PKD

Current Committee Memberships

  • NIH Cardiorenal Transplant Working GroupMember
  • Kidney Interagency Coordinating CommitteeMember
  • NIDDK-Uniformed Services University of the Health Sciences/Department of Defense Research CollaborationMember
  • American Society of Nephrology CKD Working GroupMember
  • American Society of Nephrology-FDA Kidney Health InitiativeLiaison to KHI