Current Responsibilities and Activities
I administer portfolios of research grants on gastrointestinal (GI) transport and absorption and GI host-microbial interactions. In both program areas, I am interested in supporting outstanding basic research and in encouraging the translation of basic science advances into clinical applications for treating digestive diseases.
Research projects on GI transport and absorption may focus on basic physiology of electrolyte transport in the GI tract, structure-function studies of relevant GI transport proteins, mechanisms regulating transporter function in GI health and diseases, the role of transport proteins in lipid absorption and processing in the intestine, and translational research to define host-response pathways as potential targets for treating diarrheal diseases.
Research projects in the Gastrointestinal Microbiology and Infectious Diseases program may include basic and translational studies on the cellular and molecular mechanisms mediating host-microbial homeostasis in the GI tract, host-microbial molecular interactions at the epithelial surface, the host epithelial response to luminal microbes, mechanisms regulating host innate and adaptive immune responses to commensal and pathogenic microbes in the GI tract, and modulation of the microbe-epithelial-immune axis in disease pathophysiology.