U.S. Department of Health and Human Services
Salvatore Sechi

 Contact Info

Tel: +1 301 594 8814
Email: sechis@mail.nih.gov

 Select Experience


Head, Mass Spectrometry Unit, NIA, NIH, 1999-2001

Principal Investigator, DuPont Life Sciences, 1998-1999

Research Associate, Laboratory of Mass Spectrometry, The Rockefeller University, 1996-1998

Fogarty Visiting Fellow, LEC, NCI, NIH, 1990-1993

Doctoral Degree, Department of Biology, University of Padua, Italy, 1987

Salvatore Sechi, Ph.D.

Program Director, Division of Diabetes, Endocrinology, and Metabolic Diseases

Current Responsibilities and Activities

I am the senior advisor for proteomics and systems biology.  My responsibilities include the oversight of a research program on the application of structural biology and proteomics to diabetes, endocrinology, and metabolic diseases.  The structural biology component comprises studies that are aimed at characterizing the 3-dimensional structure and function of proteins, and studies related to folding, stability, and novel structure design.  The proteomic component focuses on characterizing the proteome or subset of the proteome, with the main goal of furthering our understanding of disease etiology and pathophysiology.  For this purpose, researchers within this program often aim to identify protein biomarkers and examine signal transduction pathways and networks.  Typically, large-scale approaches such as protein arrays or mass spectrometry are applied within these types of projects.  The samples used can include biofluids or biopsies from human specimens as well as animal and cell models.  The portfolio also involves computational and bioinformatic studies that address proteomic issues as they relate to diseases of interest to the NIDDK.

The systems biology program that I manage comprises research projects that study how the higher-level properties of complex biological systems arise from the interactions among their parts.  Within this new discipline, researchers often use high-throughput technologies (e.g., genomics, proteomics, epigenomics, and metabolomics) and integrate the resulting data sets to develop models of complex biological systems.  Within this program, researchers aim to characterize molecular pathways that lead to diabetes and develop predictive models.

I am also the coordinator or science officer for several Common Fund programs.

​Research Programs

Diabetes and Endocrine Disease Bioengineering, Biotechnology, and Imaging
This program supports research that is aimed at applying sophisticated, cutting-edge technologies to advance the understanding of the mechanisms that underlie diabetes and other endocrine and metabolic diseases

Diabetes and Endocrine Disease Translational Research
The Diabetes and Endocrine Disease Translational Research program promotes research that translates scientific findings into practice to enhance human health of those with, or at risk for, metabolic disease, including diabetes and endocrine diseases

Committee Membership

NIH Common Fund Protein Capture Reagents Program, Team Leader and Program Coordinator

Big Data to Knowledge (BD2K), Member

NIH Common Fund Glycomics Working Group, Member

NIH Roadmap Building Blocks, Biological Pathways, and Networks Implementation Group, Member

NIH Common Fund National Centers for Biomedical Computing, Lead Science Officer​

Human Proteome Organization Plasma Proteome Project, NIDDK Representative

NIGMS Program on Structural Biology of Membrane Protein, NIDDK Representative

NIH Proteomic Interest Group Steering Committee, Member