U.S. Department of Health and Human Services
Adrian Bax
 

 Contact Info

 
Tel: 301-496-2848
Email: bax@nih.gov
 

 Select Experience

 
  • Ph.D.Delft University of Technology1981
  • B.S.Delft University of Technology1978
 

 Related Links

 

Adriaan Bax, Ph.D., NIH Distinguished Investigator

Chief, Laboratory of Chemical PhysicsBiophysical Nuclear Magnetic Resonance Spectroscopy Section
Specialties
  • Biomedical Engineering/Biophysics/Physics
  • Chemistry/Chemical Biology
  • Structural Biology

​Research Images

Images or videos appear below. Clicking images or videos provides an expanded view.

TitleDescriptionImage
Alpha-synucleinThe protein alpha-synuclein has been implicated in the etiology of Parkinson’s disease.  It rapidly exchanges between a disordered form, free in the cytosol, and a membrane-bound form, where it impacts trafficking of synaptic vesicles.  Acetylation of the protein’s N-terminus plays a key role in membrane binding.Alpha-synucleinEnlarge
N-terminal fusion domain of hemagglutinin, adopting a helical hairpin structure at neutral pH.Hemagglutinin is the protein that mediates entry of the influenza virus into the host cell.  Its N-terminal fusion peptide cannot be seen by x-ray crystallography, but nuclear magnetic resonance reveals a remarkable alpha-helical hairpin structure (black) that embeds itself into the endosomal membrane.  When the pH decreases below ca 5.5, this triggers transient opening of the hairpin into a dynamically interchanging V-shaped (red) and extended (blue) structure, while the hydrophobic sidechains (yellow) remain oriented to one surface.N-terminal fusion domain of hemagglutinin, adopting a helical hairpin structure at neutral pH.Enlarge
Ribbon diagram depicting the homo-dimeric catalytic core domain of the HIV1 integrase enzymeThe color coding indicates the rates at which backbone amide hydrogens exchange with solvent (blue—very slow; red—very fast), measured by nuclear magnetic resonance spectroscopy, and reports on the stability of the hydrogen bonding network.Ribbon diagram depicting the homo-dimeric catalytic core domain of the HIV1 integrase enzymeEnlarge