U.S. Department of Health and Human Services
Alan Kimmel

 Contact Info

Tel: 301-496-3016
Email: ark1@helix.nih.gov

 Select Experience

  • American Cancer Society Senior FellowshipUniversity of California, San Diego1979-1981
  • Visiting ScientistGerman Cancer Research Center1979
  • American Cancer Society FellowshipUniversity of California, San Diego1977-1979
  • Ph.D.University of Rochester1977

 Related Links

    • Cell Biology/Cell Signaling
    • Developmental Biology
    • Genetics/Genomics
    • Molecular Biology/Biochemistry


    A selection of recent and significant publications can be viewed below.

    Rosel D, Kimmel AR. The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum. Eur J Cell Biol. 2006 Sep; 85 (9-10):1023-34. [Full Text/Abstract]
    Xu G, Sztalryd C, Lu X, Tansey JT, Gan J, Dorward H, Kimmel AR, Londos C. Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. J Biol Chem. 2005 Dec 30; 280 (52):42841-7. [Full Text/Abstract]
    Liu X, Rubin JS, Kimmel AR. Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr Biol. 2005 Nov 22; 15 (22):1989-97. [Full Text/Abstract]
    Naudé B, Brzostowski JA, Kimmel AR, Wellems TE. Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT. J Biol Chem. 2005 Jul 8; 280 (27):25596-603. [Full Text/Abstract]
    Khurana T, Brzostowski JA, Kimmel AR. A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms. EMBO J. 2005 Jul 6; 24 (13):2254-64. [Full Text/Abstract]
    Faix J, Kreppel L, Shaulsky G, Schleicher M, Kimmel AR. A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system. Nucleic Acids Res. 2004 Oct 26; 32 (19):e143. [Full Text/Abstract]
    Kimmel AR, Firtel RA. Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response. Curr Opin Genet Dev. 2004 Oct; 14 (5):540-9. [Full Text/Abstract]
    Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH. Structure of a lipid droplet protein; the PAT family member TIP47. Structure. 2004 Jul; 12 (7):1199-207. [Full Text/Abstract]
    Kimmel AR, Parent CA, Gough NR. Teaching resources. Spatial and temporal dynamics of signaling components involved in the control of chemotaxis in Dictyostelium discoideum. Sci STKE. 2004 May 18; 2004 (234):tr3. [Full Text/Abstract]
    Brzostowski JA, Parent CA, Kimmel AR. A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement. Genes Dev. 2004 Apr 1; 18 (7):805-15. [Full Text/Abstract]
    Kreppel L, Fey P, Gaudet P, Just E, Kibbe WA, Chisholm RL, Kimmel AR. dictyBase: a new Dictyostelium discoideum genome database. Nucleic Acids Res. 2004 Jan 1; 32 (Database issue):D332-3. [Full Text/Abstract]
    Su CL, Sztalryd C, Contreras JA, Holm C, Kimmel AR, Londos C. Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes. J Biol Chem. 2003 Oct 31; 278 (44):43615-9. [Full Text/Abstract]
    Sztalryd C, Xu G, Dorward H, Tansey JT, Contreras JA, Kimmel AR, Londos C. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J Cell Biol. 2003 Jun 23; 161 (6):1093-103. [Full Text/Abstract]
    Tansey JT, Huml AM, Vogt R, Davis KE, Jones JM, Fraser KA, Brasaemle DL, Kimmel AR, Londos C. Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols. J Biol Chem. 2003 Mar 7; 278 (10):8401-6. [Full Text/Abstract]