U.S. Department of Health and Human Services
Alan Kimmel
 

 Contact Info

 
Tel: 301-496-3016
Email: ark1@helix.nih.gov
 

 Select Experience

 
  • American Cancer Society Senior FellowshipUniversity of California, San Diego1979-1981
  • Visiting ScientistGerman Cancer Research Center1979
  • American Cancer Society FellowshipUniversity of California, San Diego1977-1979
  • Ph.D.University of Rochester1977
 

 Related Links

 
    Specialties
    • Cell Biology/Cell Signaling
    • Developmental Biology
    • Genetics/Genomics
    • Molecular Biology/Biochemistry

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Kimmel AR, Sztalryd C. Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization. Curr Opin Lipidol. 2014 Apr; 25 (2):110-7. [Full Text/Abstract]
    Ludtmann MH, Otto GP, Schilde C, Chen ZH, Allan CY, Brace S, Beesley PW, Kimmel AR, Fisher P, Killick R, Williams RS. An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum. J Cell Sci. 2014 Apr 1; 127 (Pt 7):1576-84. [Full Text/Abstract]
    Sztalryd C, Kimmel AR. Perilipins: Lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection. Biochimie. 2014 Jan; 96 :96-101. [Full Text/Abstract]
    Platt JL, Rogers BJ, Rogers KC, Harwood AJ, Kimmel AR. Different CHD chromatin remodelers are required for expression of distinct gene sets and specific stages during development of Dictyostelium discoideum. Development. 2013 Dec; 140 (24):4926-36. [Full Text/Abstract]
    Brzostowski JA, Sawai S, Rozov O, Liao XH, Imoto D, Parent CA, Kimmel AR. Phosphorylation of chemoattractant receptors regulates chemotaxis, actin re-organization, and signal-relay. J Cell Sci. 2013 Oct 15; 126 (Pt 20):4614-26. [Full Text/Abstract]
    Liao XH, Buggey J, Lee YK, Kimmel AR. Chemoattractant stimulation of TORC2 is regulated by receptor/G protein-targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium. Mol Biol Cell. 2013 Jul; 24 (13):2146-55. [Full Text/Abstract]
    Platt JL, Kent NA, Harwood AJ, Kimmel AR. Analysis of chromatin organization by deep sequencing technologies. Methods Mol Biol. 2013; 983 :173-83. [Full Text/Abstract]
    Faix J, Linkner J, Nordholz B, Platt JL, Liao XH, Kimmel AR. The application of the Cre-loxP system for generating multiple knock-out and knock-in targeted loci. Methods Mol Biol. 2013; 983 :249-67. [Full Text/Abstract]
    Hsieh K, Lee YK, Londos C, Raaka BM, Dalen KT, Kimmel AR. Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. J Cell Sci. 2012 Sep 1; 125 (Pt 17):4067-76. [Full Text/Abstract]
    Rosel D, Khurana T, Majithia A, Huang X, Bhandari R, Kimmel AR. TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing. J Cell Sci. 2012 Jan 1; 125 (Pt 1):37-48. [Full Text/Abstract]
    Kim L, Brzostowski J, Majithia A, Lee NS, McMains V, Kimmel AR. Combinatorial cell-specific regulation of GSK3 directs cell differentiation and polarity in Dictyostelium. Development. 2011 Feb; 138 (3):421-30. [Full Text/Abstract]
    McMains VC, Myre M, Kreppel L, Kimmel AR. Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex. Dis Model Mech. 2010 Sep-Oct; 3 (9-10):581-94. [Full Text/Abstract]
    Liao XH, Buggey J, Kimmel AR. Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. J Cell Sci. 2010 Mar 15; 123 (Pt 6):983-92. [Full Text/Abstract]
    Kimmel AR, Brasaemle DL, McAndrews-Hill M, Sztalryd C, Londos C. Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res. 2010 Mar; 51 (3):468-71. [Full Text/Abstract]
    Kimmel AR. An orphan nuclear receptor finds a home. Mol Cell. 2010 Jan 29; 37 (2):155-7. [Full Text/Abstract]
    Liao XH, Kimmel AR. Biochemical responses to chemoattractants in Dictyostelium: ligand-receptor interactions and downstream kinase activation. Methods Mol Biol. 2009; 571 :271-81. [Full Text/Abstract]
    Liao XH, Majithia A, Huang X, Kimmel AR. Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism. Amino Acids. 2008 Nov; 35 (4):761-70. [Full Text/Abstract]
    McMains VC, Liao XH, Kimmel AR. Oscillatory signaling and network responses during the development of Dictyostelium discoideum. Ageing Res Rev. 2008 Jul; 7 (3):234-48. [Full Text/Abstract]
    Bokko PB, Francione L, Bandala-Sanchez E, Ahmed AU, Annesley SJ, Huang X, Khurana T, Kimmel AR, Fisher PR. Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. Mol Biol Cell. 2007 May; 18 (5):1874-86. [Full Text/Abstract]
    Sztalryd C, Bell M, Lu X, Mertz P, Hickenbottom S, Chang BH, Chan L, Kimmel AR, Londos C. Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line. J Biol Chem. 2006 Nov 10; 281 (45):34341-8. [Full Text/Abstract]
    Kim L, Kimmel AR. GSK3 at the edge: regulation of developmental specification and cell polarization. Curr Drug Targets. 2006 Nov; 7 (11):1411-9. [Full Text/Abstract]
    Brzostowski JA, Kimmel AR. Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay. Mol Biol Cell. 2006 Oct; 17 (10):4220-7. [Full Text/Abstract]
    Rosel D, Kimmel AR. The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum. Eur J Cell Biol. 2006 Sep; 85 (9-10):1023-34. [Full Text/Abstract]
    Xu G, Sztalryd C, Lu X, Tansey JT, Gan J, Dorward H, Kimmel AR, Londos C. Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. J Biol Chem. 2005 Dec 30; 280 (52):42841-7. [Full Text/Abstract]
    Liu X, Rubin JS, Kimmel AR. Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr Biol. 2005 Nov 22; 15 (22):1989-97. [Full Text/Abstract]
    Naudé B, Brzostowski JA, Kimmel AR, Wellems TE. Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT. J Biol Chem. 2005 Jul 8; 280 (27):25596-603. [Full Text/Abstract]
    Khurana T, Brzostowski JA, Kimmel AR. A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms. EMBO J. 2005 Jul 6; 24 (13):2254-64. [Full Text/Abstract]
    Faix J, Kreppel L, Shaulsky G, Schleicher M, Kimmel AR. A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system. Nucleic Acids Res. 2004 Oct 26; 32 (19):e143. [Full Text/Abstract]
    Kimmel AR, Firtel RA. Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response. Curr Opin Genet Dev. 2004 Oct; 14 (5):540-9. [Full Text/Abstract]
    Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH. Structure of a lipid droplet protein; the PAT family member TIP47. Structure. 2004 Jul; 12 (7):1199-207. [Full Text/Abstract]