U.S. Department of Health and Human Services
Alan Schechter
 

 Contact Info

 
Tel: 301-496-5408
Email: aschecht@helix.nih.gov
 

 Select Experience

 
  • Special Research FellowNIAMS, NIH1967-1969
  • Research AssociateNIAMS, NIH1965-1967
  • ResidentAlbert Einstein Medical College1963-1965
  • M.D.Columbia University1963
  • B.A.Cornell University1959
 

 Related Links

 
Specialties
  • Molecular Biology/Biochemistry
  • Molecular Pharmacology/Toxicology

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Park JW, Piknova B, Nghiem K, Lozier JN, Schechter AN. Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography. Nitric Oxide. 2014 Aug 31; 40 (40; 2014 Aug 31):45-51. [Full Text/Abstract]
Park JW, Piknova B, Kurtz J, Seetharaman S, Wagner SJ, Schechter AN. Effect of storage on levels of nitric oxide metabolites in platelet preparations. Transfusion. 2013 Mar; 53 (2013 Mar; 3; 53):637-44. [Full Text/Abstract]
Cokic VP, Bhattacharya B, Beleslin-Cokic BB, Noguchi CT, Puri RK, Schechter AN. JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny. J Transl Med. 2012 Jun 7; 10 (2012 Jun 7; 10):116. [Full Text/Abstract]
Machha A, Schechter AN. Inorganic nitrate: a major player in the cardiovascular health benefits of vegetables?. Nutr Rev. 2012 Jun; 70 (2012 Jun; 6; 70):367-72. [Full Text/Abstract]
Srihirun S, Sriwantana T, Unchern S, Kittikool D, Noulsri E, Pattanapanyasat K, Fucharoen S, Piknova B, Schechter AN, Sibmooh N. Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation. PLoS One. 2012; 7 (2012; 7; 1):e30380. [Full Text/Abstract]
Piknova B, Kocharyan A, Schechter AN, Silva AC. The role of nitrite in neurovascular coupling. Brain Res. 2011 Aug 17; 1407 (1407; 2011 Aug 17):62-8. [Full Text/Abstract]
Machha A, Schechter AN. Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. Eur J Nutr. 2011 Aug; 50 (50; 2011 Aug; 5):293-303. [Full Text/Abstract]
Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT. Acute erythropoietin cardioprotection is mediated by endothelial response. Basic Res Cardiol. 2011 May; 106 (106; 3; 2011 May):343-54. [Full Text/Abstract]
Beleslin-Čokić BB, Cokić VP, Wang L, Piknova B, Teng R, Schechter AN, Noguchi CT. Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells. Cytokine. 2011 May; 54 (2; 54; 2011 May):129-35. [Full Text/Abstract]
Piknova B, Schechter AN. Measurement of nitrite in blood samples using the ferricyanide-based hemoglobin oxidation assay. Methods Mol Biol. 2011; 704 (704; 2011):39-56. [Full Text/Abstract]
Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol. 2009 Dec; 5 (12; 5; 2009 Dec):865-9. [Full Text/Abstract]
Cokić VP, Beleslin-Cokić BB, Smith RD, Economou AP, Wahl LM, Noguchi CT, Schechter AN. Stimulated stromal cells induce gamma-globin gene expression in erythroid cells via nitric oxide production. Exp Hematol. 2009 Oct; 37 (2009 Oct; 37; 10):1230-7. [Full Text/Abstract]
Piknova B, Keszler A, Hogg N, Schechter AN. The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies. Nitric Oxide. 2009 Mar; 20 (20; 2; 2009 Mar):88-94. [Full Text/Abstract]
Schechter AN. Hemoglobin research and the origins of molecular medicine. Blood. 2008 Nov 15; 112 (2008 Nov 15; 10; 112):3927-38. [Full Text/Abstract]
Keszler A, Piknova B, Schechter AN, Hogg N. The reaction between nitrite and oxyhemoglobin: a mechanistic study. J Biol Chem. 2008 Apr 11; 283 (283; 15; 2008 Apr 11):9615-22. [Full Text/Abstract]
Sibmooh N, Piknova B, Rizzatti F, Schechter AN. Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes. Biochemistry. 2008 Mar 4; 47 (2008 Mar 4; 9; 47):2989-96. [Full Text/Abstract]
Cokic VP, Andric SA, Stojilkovic SS, Noguchi CT, Schechter AN. Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells. Blood. 2008 Feb 1; 111 (111; 3; 2008 Feb 1):1117-23. [Full Text/Abstract]
Chen K, Piknova B, Pittman RN, Schechter AN, Popel AS. Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes. Nitric Oxide. 2008 Feb; 18 (2008 Feb; 1; 18):47-60. [Full Text/Abstract]
Cokić VP, Schechter AN. Effects of nitric oxide on red blood cell development and phenotype. Curr Top Dev Biol. 2008; 82 (82; 2008):169-215. [Full Text/Abstract]
Dejam A, Hunter CJ, Tremonti C, Pluta RM, Hon YY, Grimes G, Partovi K, Pelletier MM, Oldfield EH, Cannon RO 3rd, Schechter AN, Gladwin MT. Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Circulation. 2007 Oct 16; 116 (2007 Oct 16; 16; 116):1821-31. [Full Text/Abstract]
Deans KJ, Minneci PC, Suffredini AF, Danner RL, Hoffman WD, Ciu X, Klein HG, Schechter AN, Banks SM, Eichacker PQ, Natanson C. Randomization in clinical trials of titrated therapies: unintended consequences of using fixed treatment protocols. Crit Care Med. 2007 Jun; 35 (6; 35; 2007 Jun):1509-16. [Full Text/Abstract]
Cokic VP, Beleslin-Cokic BB, Noguchi CT, Schechter AN. Hydroxyurea increases eNOS protein levels through inhibition of proteasome activity. Nitric Oxide. 2007 May; 16 (2007 May; 16; 3):371-8. [Full Text/Abstract]
Oneal PA, Gantt NM, Schwartz JD, Bhanu NV, Lee YT, Moroney JW, Reed CH, Schechter AN, Luban NL, Miller JL. Fetal hemoglobin silencing in humans. Blood. 2006 Sep 15; 108 (2006 Sep 15; 108; 6):2081-6. [Full Text/Abstract]
Pelletier MM, Kleinbongard P, Ringwood L, Hito R, Hunter CJ, Schechter AN, Gladwin MT, Dejam A. The measurement of blood and plasma nitrite by chemiluminescence: pitfalls and solutions. Free Radic Biol Med. 2006 Aug 15; 41 (41; 2006 Aug 15; 4):541-8. [Full Text/Abstract]
Cokic VP, Beleslin-Cokic BB, Tomic M, Stojilkovic SS, Noguchi CT, Schechter AN. Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells. Blood. 2006 Jul 1; 108 (108; 2006 Jul 1; 1):184-91. [Full Text/Abstract]
Kim-Shapiro DB, Schechter AN, Gladwin MT. Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics. Arterioscler Thromb Vasc Biol. 2006 Apr; 26 (4; 2006 Apr; 26):697-705. [Full Text/Abstract]
Kleinbongard P, Dejam A, Lauer T, Jax T, Kerber S, Gharini P, Balzer J, Zotz RB, Scharf RE, Willers R, Schechter AN, Feelisch M, Kelm M. Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med. 2006 Jan 15; 40 (40; 2006 Jan 15; 2):295-302. [Full Text/Abstract]
Crawford JH, Isbell TS, Huang Z, Shiva S, Chacko BK, Schechter AN, Darley-Usmar VM, Kerby JD, Lang JD Jr, Kraus D, Ho C, Gladwin MT, Patel RP. Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood. 2006 Jan 15; 107 (107; 2006 Jan 15; 2):566-74. [Full Text/Abstract]
Piknova B, Gladwin MT, Schechter AN, Hogg N. Electron paramagnetic resonance analysis of nitrosylhemoglobin in humans during NO inhalation. J Biol Chem. 2005 Dec 9; 280 (280; 2005 Dec 9; 49):40583-8. [Full Text/Abstract]
Minneci PC, Deans KJ, Zhi H, Yuen PS, Star RA, Banks SM, Schechter AN, Natanson C, Gladwin MT, Solomon SB. Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest. 2005 Dec; 115 (115; 2005 Dec; 12):3409-17. [Full Text/Abstract]
Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO 3rd, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR Jr, Feelisch M, Lundberg JO. The emerging biology of the nitrite anion. Nat Chem Biol. 2005 Nov; 1 (6; 2005 Nov; 1):308-14. [Full Text/Abstract]
Huang Z, Shiva S, Kim-Shapiro DB, Patel RP, Ringwood LA, Irby CE, Huang KT, Ho C, Hogg N, Schechter AN, Gladwin MT. Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. J Clin Invest. 2005 Aug; 115 (8; 115; 2005 Aug):2099-107. [Full Text/Abstract]
Dejam A, Hunter CJ, Pelletier MM, Hsu LL, Machado RF, Shiva S, Power GG, Kelm M, Gladwin MT, Schechter AN. Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood. 2005 Jul 15; 106 (106; 2005 Jul 15; 2):734-9. [Full Text/Abstract]
Schechter AN, Perlman RL, Rettig RA. Why is revitalizing clinical research so important, yet so difficult?. Perspect Biol Med. 2004 Autumn; 47 (2004 Autumn; 4; 47):476-86. [Full Text/Abstract]