U.S. Department of Health and Human Services
Ann Dean
 

 Contact Info

 
Tel: 301-496-6068
Email: anndean@helix.nih.gov
 

 Select Experience

 
  • Ph.D.The George Washington University1981
  • B.A.Bucknell University1966
 

 Related Links

 

    Specialties
    • Chromosome Biology/Epigenetics
    • Developmental Biology
    • Molecular Biology/Biochemistry

    ​Research Images

    Images or videos appear below. Clicking images or videos provides an expanded view.

    TitleDescriptionImage
    A working model of the relationship between chromatin looping and transcription activation in the β-globin locusIn erythroid cells, the β-globin LCR and gene are occupied by the Ldb1/LMO2/TAL1/GATA-1 complex, and Ldb1 dimerization is the basis of loop formation (Song, et al., Molecular Cell, 2007; Deng et al., Cell, 2012).  The locus moves from the nuclear periphery to the interior for robust transcription of the gene in transcription factories (Song et al., Blood, 2010).  (A) Looping could be promoted by pol II density and by transcription in a factory.  (B) Alternatively, looping might be facilitated by a cell-type specific chromosomal organization that is stabilized by Ldb1 dimerization (reviewed in Krivega and Dean, Current Opinion in Genetics & Development, 2012).  Mutational analysis of Ldb1 favors the latter model (I. Krivega and A. Dean, unpublished).A working model of the relationship between chromatin looping and transcription activation in the β-globin locusEnlarge
    Summer 2012 Lab Members(Left to right) JJ Lee, Jennifer Plank, Jun Zhang, Ann Dean, Maria Soledad Ivaldi, Ji-Hyun Oum, and Ivan KrivegaSummer 2012 Lab MembersEnlarge