U.S. Department of Health and Human Services
Carole Bewley

 Contact Info

Tel: 301-594-5187
Email: caroleb@mail.nih.gov

 Select Experience

  • Ph.D.University of California, San Diego1995

 Related Links

  • Chemistry/Chemical Biology


A selection of recent and significant publications can be viewed below.

Mason RD, Welles HC, Adams C, Chakrabarti BK, Gorman J, Zhou T, Nguyen R, O'Dell S, Lusvarghi S, Bewley CA, Li H, Shaw GM, Sheng Z, Shapiro L, Wyatt R, Kwong PD, Mascola JR, Roederer M. Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability. PLoS Pathog. 2016 Apr; 12 (2016 Apr; 4; 12):e1005537. [Full Text/Abstract]
Dogo-Isonagie C, Lee SL, Lohith K, Liu H, Mandadapu SR, Lusvarghi S, O'Connor RD, Bewley CA. Design and synthesis of small molecule-sulfotyrosine mimetics that inhibit HIV-1 entry. Bioorg Med Chem. 2016 Mar 3; 24 (8; 24; 2016 Mar 3):1718-28. [Full Text/Abstract]
Lusvarghi S, Ghirlando R, Wong CH, Bewley CA. Glycopeptide mimetics recapitulate high-mannose-type oligosaccharide binding and function. Angew Chem Int Ed Engl. 2015 Mar 16; 54 (2015 Mar 16; 19; 54):5603-8. [Full Text/Abstract]
Acharya P, Lusvarghi S, Bewley CA, Kwong PD. HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth. Expert Opin Ther Targets. 2015 Feb 27; 19 (6; 19; 2015 Feb 27):1-19. [Full Text/Abstract]
Sastry M, Bewley CA, Kwong PD. Effective isotope labeling of proteins in a mammalian expression system. Methods Enzymol. 2015; 565 (565; 2015):289-307. [Full Text/Abstract]
Kachko A, Loesgen S, Shahzad-Ul-Hussan S, Tan W, Zubkova I, Takeda K, Wells F, Rubin S, Bewley CA, Major ME. Inhibition of hepatitis C virus by the cyanobacterial protein Microcystis viridis lectin: mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA. Mol Pharm. 2013 Dec 2; 10 (2013 Dec 2; 12; 10):4590-602. [Full Text/Abstract]
Bewley CA, Shahzad-ul-Hussan S. Characterizing carbohydrate-protein interactions by nuclear magnetic resonance spectroscopy. Biopolymers. 2013 Oct; 99 (2013 Oct; 99; 10):796-806. [Full Text/Abstract]
Keffer JL, Huecas S, Hammill JT, Wipf P, Andreu JM, Bewley CA. Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria. Bioorg Med Chem. 2013 Sep 15; 21 (2013 Sep 15; 21; 18):5673-8. [Full Text/Abstract]
Pancera M, Shahzad-Ul-Hussan S, Doria-Rose NA, McLellan JS, Bailer RT, Dai K, Loesgen S, Louder MK, Staupe RP, Yang Y, Zhang B, Parks R, Eudailey J, Lloyd KE, Blinn J, Alam SM, Haynes BF, Amin MN, Wang LX, Burton DR, Koff WC, Nabel GJ, Mascola JR, Bewley CA, Kwong PD. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nat Struct Mol Biol. 2013 Jul; 20 (20; 7; 2013 Jul):804-13. [Full Text/Abstract]
Shahzad-ul-Hussan S, Ghirlando R, Dogo-Isonagie CI, Igarashi Y, Balzarini J, Bewley CA. Characterization and carbohydrate specificity of pradimicin S. J Am Chem Soc. 2012 Aug 1; 134 (30; 2012 Aug 1; 134):12346-9. [Full Text/Abstract]
Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA. Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. J Biol Chem. 2012 Apr 27; 287 (287; 2012 Apr 27; 18):15076-86. [Full Text/Abstract]
McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Kwon YD, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 2011 Nov 23; 480 (2011 Nov 23; 480; 7377):336-43. [Full Text/Abstract]
Acharya P, Dogo-Isonagie C, LaLonde JM, Lam SN, Leslie GJ, Louder MK, Frye LL, Debnath AK, Greenwood JR, Luongo TS, Martin L, Watts KS, Hoxie JA, Mascola JR, Bewley CA, Kwong PD. Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry. ACS Chem Biol. 2011 Oct 21; 6 (6; 2011 Oct 21; 10):1069-77. [Full Text/Abstract]
Shahzad-ul-Hussan S, Gustchina E, Ghirlando R, Clore GM, Bewley CA. Solution structure of the monovalent lectin microvirin in complex with Man(alpha)(1-2)Man provides a basis for anti-HIV activity with low toxicity. J Biol Chem. 2011 Jun 10; 286 (2011 Jun 10; 23; 286):20788-96. [Full Text/Abstract]
Plaza A, Keffer JL, Bifulco G, Lloyd JR, Bewley CA. Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ. J Am Chem Soc. 2010 Jul 7; 132 (2010 Jul 7; 132; 26):9069-77. [Full Text/Abstract]
Shahzad-ul-Hussan S, Cai M, Bewley CA. Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL. J Am Chem Soc. 2009 Nov 18; 131 (131; 2009 Nov 18; 45):16500-8. [Full Text/Abstract]
Gutierrez-Lugo MT, Baker H, Shiloach J, Boshoff H, Bewley CA. Dequalinium, a new inhibitor of Mycobacterium tuberculosis mycothiol ligase identified by high-throughput screening. J Biomol Screen. 2009 Jul; 14 (6; 14; 2009 Jul):643-52. [Full Text/Abstract]