U.S. Department of Health and Human Services
Carole Bewley
 

 Contact Info

 
Tel: 301-594-5187
Email: caroleb@mail.nih.gov
 

 Select Experience

 
  • Ph.D.University of California, San Diego1995
 

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    Carole A. Bewley, Ph.D.

    Senior Investigator, Laboratory of Bioorganic ChemistryNatural Products Chemistry Section
    Specialties
    • Chemistry/Chemical Biology

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Vassilopoulos A, Xiao C, Chisholm C, Chen W, Xu X, Lahusen TG, Bewley C, Deng CX. Synergistic therapeutic effect of cisplatin and PI3K inhibitors in cancer growth and metastasis of Brca1 mutant tumors. J Biol Chem. 2014 Jul 8. [Full Text/Abstract]
    Shahzad-ul-Hussan S, Ghirlando R, Dogo-Isonagie CI, Igarashi Y, Balzarini J, Bewley CA. Characterization and carbohydrate specificity of pradimicin S. J Am Chem Soc. 2012 Aug 1; 134 (30):12346-9. [Full Text/Abstract]
    Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA. Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. J Biol Chem. 2012 Apr 27; 287 (18):15076-86. [Full Text/Abstract]
    McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Kwon YD, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 2011 Nov 23; 480 (7377):336-43. [Full Text/Abstract]
    Acharya P, Dogo-Isonagie C, LaLonde JM, Lam SN, Leslie GJ, Louder MK, Frye LL, Debnath AK, Greenwood JR, Luongo TS, Martin L, Watts KS, Hoxie JA, Mascola JR, Bewley CA, Kwong PD. Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry. ACS Chem Biol. 2011 Oct 21; 6 (10):1069-77. [Full Text/Abstract]
    Shahzad-ul-Hussan S, Gustchina E, Ghirlando R, Clore GM, Bewley CA. Solution structure of the monovalent lectin microvirin in complex with Man(alpha)(1-2)Man provides a basis for anti-HIV activity with low toxicity. J Biol Chem. 2011 Jun 10; 286 (23):20788-96. [Full Text/Abstract]
    Plaza A, Keffer JL, Bifulco G, Lloyd JR, Bewley CA. Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ. J Am Chem Soc. 2010 Jul 7; 132 (26):9069-77. [Full Text/Abstract]
    Shahzad-ul-Hussan S, Cai M, Bewley CA. Unprecedented glycosidase activity at a lectin carbohydrate-binding site exemplified by the cyanobacterial lectin MVL. J Am Chem Soc. 2009 Nov 18; 131 (45):16500-8. [Full Text/Abstract]
    Gutierrez-Lugo MT, Baker H, Shiloach J, Boshoff H, Bewley CA. Dequalinium, a new inhibitor of Mycobacterium tuberculosis mycothiol ligase identified by high-throughput screening. J Biomol Screen. 2009 Jul; 14 (6):643-52. [Full Text/Abstract]
    Lam SN, Acharya P, Wyatt R, Kwong PD, Bewley CA. Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry. Bioorg Med Chem. 2008 Dec 1; 16 (23):10113-20. [Full Text/Abstract]
    Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD. Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science. 2007 Sep 28; 317 (5846):1930-4. [Full Text/Abstract]
    Louis JM, Nesheiwat I, Chang L, Clore GM, Bewley CA. Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion. J Biol Chem. 2003 May 30; 278 (22):20278-85. [Full Text/Abstract]