Our lab employs a wide range of methods to identify and study chemical compounds found in the natural world that can be useful medically. We have a particular interest in engineering compounds that prevent HIV-1 infection by blocking the virus from fusing into healthy cells. We are also studying single-celled organisms to identify new compounds involved in the biologically important process of binding proteins to carbohydrates. This process is important in many contexts, including human reproduction and the spread of cancer cells. New proteins that bind to carbohydrates may ultimately form the basis for developing new treatment strategies.