U.S. Department of Health and Human Services
Caroline Philpott
 

 Contact Info

 
Tel: 301-435-4018
Email: carolinep@intra.niddk.nih.gov
 

 Select Experience

 
  • Clinical Associate in GeneticsNICHD, NIH1995–1998
  • Postdoctoral FellowNICHD, NIH1990–1995
  • Resident in Internal MedicineJohns Hopkins Hospital1987–1990
  • M.D.Duke University1987
  • B.A.Duke University1983
 

 Related Links

 

    Caroline C. Philpott, M.D.

    Chief, Liver Diseases BranchGenetics and Metabolism Section
    Specialties
    • Cell Biology/Cell Signaling
    • Genetics/Genomics
    • Molecular Biology/Biochemistry
    • Systems Biology

    ​Research Images

    Images or videos appear below. Clicking images or videos provides an expanded view.

    TitleDescriptionImage
    Color image depicting the process of iron homeostasis in yeastThis image depicts iron homeostasis in yeast.  Proteins expressed as part of the Aft1 and 2 regulon are labeled in black text.  The low affinity iron transporters Smf1 and Fet4 are also shown.  Genes that are downregulated in iron deficiency are indicated in gray text.Color image depicting the process of iron homeostasis in yeastEnlarge
    Color model depicting PCBP1 delivering iron to ferritinThis image depicts a model of PCBP1 delivering iron to ferritin.  PCBP1 binds 3 Fe(II) ions and binds to ferritin, delivering the iron for mineralization of the ferritin core.Color model depicting PCBP1 delivering iron to ferritinEnlarge
    Color image depicting PCBP iron chaperones in mammalian cellsThis image depicts circulating iron binds to transferrin (Tf), which binds to transferrin receptor (TfR) on the cell surface.  Endocytosis internalizes ferric Tf/TfR complex and transferrin releases iron reduced to ferrous form.  DMT1 transports ferrous iron to the cytosol.  PCBP iron chaperones deliver it to cytosolic iron enzymes.  Iron also transfers to mitochondria.Color image depicting PCBP iron chaperones in mammalian cellsEnlarge