U.S. Department of Health and Human Services
Christopher Koh

 Contact Info

Tel: 301-443-9402
Email: kohchris@mail.nih.gov

 Select Experience

  • Gastroenterology FellowshipUniversity of Maryland School of Medicine, NIDDK, NIH2010-2013 
  • Hepatology FellowshipNIDDK, NIH2007-2010
  • Chief Medical ResidentHarbor Hospital2006-2007
  • Internal Medicine ResidencyHarbor Hospital2004-2007
  • M.H.Sc.Duke University School of Medicine2008-2012
  • M.D.Saba University School of Medicine2000-2004
  • Graduate Certificate in Healthcare AdministrationSeton Hall University1998-2000

 Related Links


Christopher Koh, M.D. M.H.Sc.

Staff Clinician, Liver Diseases Virology SectionLiver Diseases Branch


A selection of recent and significant publications can be viewed below.

Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA. Structures of Yeast 80S Ribosome-tRNA Complexes in the Rotated and Nonrotated Conformations. Structure. 22 (8; 22):1210-8. [Full Text/Abstract]
Koh CS, Kang M, Usherwood T. I demand to be treated as the person I am': experiences of accessing primary health care for Australian adults who identify as gay, lesbian, bisexual, transgender or queer. Sex Health. 11 (3; 11):258-64. [Full Text/Abstract]
Heller T, Rotman Y, Koh C, Clark S, Haynes-Williams V, Chang R, McBurney R, Schmid P, Albrecht J, Kleiner DE, Ghany MG, Liang TJ, Hoofnagle JH. Long-term therapy of chronic delta hepatitis with peginterferon alfa. Aliment Pharmacol Ther. 2014 Jul; 40 (40; 2014 Jul; 1):93-104. [Full Text/Abstract]
Yunos NY, Tan WS, Koh CL, Sam CK, Mohamad NI, Tan PW, Adrian TG, Yin WF, Chan KG. Pseudomonas cremoricolorata strain ND07 produces N-acyl homoserine lactones as quorum sensing molecules. Sensors (Basel). 14 (14; 7):11595-11604. [Full Text/Abstract]
Takizawa S, Kaneyama T, Tsugane S, Takeichi N, Yanagisawa S, Ichikawa M, Yagita H, Kim BS, Koh CS. Role of the Programmed Death-1 (PD-1) pathway in regulation of Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neuroimmunol. [Full Text/Abstract]
Mehta A, Ramachandra CJ, Sequiera GL, Sudibyo Y, Nandihalli M, Yong PJ, Koh CH, Shim W. Phasic Modulation of Wnt Signaling Enhances Cardiac Differentiation in Human Pluripotent Stem Cells by Recapitulating Developmental Ontogeny. Biochim Biophys Acta. 1843 (1843; 11):2394-2402. [Full Text/Abstract]
Hoon JL, Li HY, Koh CG. POPX2 phosphatase regulates cell polarity and centrosome placement. Cell Cycle. 13 (15; 13). [Full Text/Abstract]
Sakiani S, Koh C, Heller T. Understanding The Presence of False Positive Antibodies in Acute Hepatitis. J Infect Dis. 2014 Jun 18; 210 (2014 Jun 18; 210; 12):1886-9. [Full Text/Abstract]
Lee BR, Koh CA, Sum AK. Quantitative measurement and mechanisms for CH4 production from hydrates with the injection of liquid CO2.. Phys Chem Chem Phys. [Full Text/Abstract]
Parkin IA, Koh C, Tang H, Robinson SJ, Kagale S, Clarke WE, Town CD, Nixon J, Krishnakumar V, Bidwell SL, Denoeud F, Belcram H, Links MG, Just J, Clarke C, Bender T, Huebert T, Mason AS, Pires JC, Barker G, Moore J, Walley PG, Manoli S, Batley J, Edwards D, Nelson MN, Wang X, Paterson AH, King G, Bancroft I, Chalhoub B, Sharpe AG. Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea. Genome Biol. 2014 Jun 10; 15 (6; 15; 2014 Jun 10):R77. [Full Text/Abstract]
Koh CS, Brilot AF, Grigorieff N, Korostelev AA. Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center. Proc Natl Acad Sci U S A. [Full Text/Abstract]
Harris-Hayes M, Steger-May K, Koh C, Royer NK, Graci V, Salsich GB. Classification of lower extremity movement patterns based on visual assessment: reliability and correlation with 2-dimensional video analysis. J Athl Train. 2014 Jun; 49 (49; 3; 2014 Jun):304-10. [Full Text/Abstract]
Tan ES, Koh C, Law HY, Tan GP, Lai AH, Ng IS. Haemoglobin E-beta Thalassaemia in Singapore. Ann Acad Med Singapore. 2014 Jun; 43 (6; 43; 2014 Jun):331-3. [Full Text/Abstract]
Sananes N, Favre R, Koh CJ, Zaloszyc A, Braun MC, Roth DR, Moog R, Becmeur F, Belfort MA, Ruano R. Urological fistulas after fetal cystoscopic laser ablation of posterior urethral valves - surgical technical aspects. Ultrasound Obstet Gynecol. [Full Text/Abstract]
Koo B, Lee HG, Nam Y, Kang H, Koh CS, Shin HC, Choi S. A Hybrid NIRS-EEG System for Self-Paced Brain Computer Interface with Online Motor Imagery. J Neurosci Methods. [Full Text/Abstract]
Koh CH, Lee HS, Chung SK. Effect of topical epigallocatechin gallate on corneal neovascularization in rabbits. Cornea. 33 (33; 5):527-32. [Full Text/Abstract]
Kagale S, Koh C, Nixon J, Bollina V, Clarke WE, Tuteja R, Spillane C, Robinson SJ, Links MG, Clarke C, Higgins EE, Huebert T, Sharpe AG, Parkin IA. The emerging biofuel crop Camelina sativa retains a highly undifferentiated hexaploid genome structure. Nat Commun. 2014 Apr 23; 5 (2014 Apr 23; 5):3706. [Full Text/Abstract]
Gan SH, Khinmar KW, Barkham TM, Koh CK, Shen L, Wang YT, Chee CB. Interferon-γ responses to Mycobacterium tuberculosis-specific antigens in diabetes mellitus. Eur Respir J. [Full Text/Abstract]
Said EA, Al-Yafei F, Zadjali F, Hasson SS, Al-Balushi MS, Al-Mahruqi S, Koh CY, Al-Naamani K, Al-Busaidi JZ, Idris MA, Balkhair A, Al-Jabri AA. Association of Single-Nucleotide Polymorphisms in TLR7 (Gln11Leu) and TLR9 (1635A/G) with a Higher CD4T Cell Count During HIV Infection. Immunol Lett. [Full Text/Abstract]
Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG. Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. PLoS Negl Trop Dis. 8 (8; 4):e2775. [Full Text/Abstract]
Koon YL, Koh CG, Chiam KH. Computational modeling reveals optimal strategy for kinase transport by microtubules to nerve terminals. PLoS One. 01 Apr 2014; 9 (01 Apr 2014; 4; 9):e92437. [Full Text/Abstract]
Koh C, Liang TJ. What is the future of ribavirin therapy for hepatitis C?. Antiviral Res. 2014 Apr; 104 (104; 2014 Apr):34-9. [Full Text/Abstract]
Prybutok GL, Koh C, Prybutok VR. A content relevance model for social media health information. Comput Inform Nurs. 2014 Apr; 32 (32; 4; 2014 Apr):189-200. [Full Text/Abstract]
Chow WZ, Nizam S, Ong LY, Ng KT, Chan KG, Takebe Y, Koh C, Kamarulzaman A, Tee KK. Genome Sequence of a Complex HIV-1 Unique Recombinant Form Involving CRF01_AE, Subtype B, and Subtype B' Identified in Malaysia. Genome Announc. 2014 Mar 27; 2 (2; 2014 Mar 27). [Full Text/Abstract]
Tomiki H, Kaneyama T, Kobayashi K, Inaba Y, Ichikawa M, Yagita H, Kim BS, Koh CS. Therapeutic effect of anti-αv integrin mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Neuroimmunol. 268 (1-2; 268):25-34. [Full Text/Abstract]
Hidaka Y, Inaba Y, Matsuda K, Itoh M, Kaneyama T, Nakazawa Y, Koh CS, Ichikawa M. Cytokine production profiles in chronic relapsing-remitting experimental autoimmune encephalomyelitis: IFN-γ and TNF-α are important participants in the first attack but not in the relapse. J Neurol Sci. [Full Text/Abstract]
Al-Mahruqi SH, Zadjali F, Beja-Pereira A, Koh CY, Balkhair A, Al-Jabri AA. Genetic diversity and prevalence of CCR2-CCR5 gene polymorphisms in the Omani population. Genet Mol Biol. 37 (37; 1):7-14. [Full Text/Abstract]
Warrier S, Hwang S, Koh CE, Shepherd H, Mak C, Carmalt H, Solomon M. Preservation or division of the intercostobrachial nerve in axillary dissection for breast cancer: meta-analysis of randomised controlled trials. Breast. [Full Text/Abstract]
Phang HQ, Hoon JL, Lai SK, Zeng Y, Chiam KH, Li HY, Koh CG. POPX2 phosphatase regulates the KIF3 kinesin motor complex. J Cell Sci. 127 (127; Pt 4):727-39. [Full Text/Abstract]
Harris-Hayes M, Steger-May K, Koh C, Royer NK, Graci V, Salsich GB. Classification of Lower Extremity Movement Patterns Based on Visual Assessment: Reliability and Correlation With 2-Dimensional Video Analysis. J Athl Train. [Full Text/Abstract]
Tan WC, Ong M, Han J, Mattheos N, Pjetursson BE, Tsai AY, Sanz I, Wong MC, Lang NP, ITI Antibiotic Study Group. Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy - a multicenter randomized controlled clinical trial. Clin Oral Implants Res. 25 (25; 2):185-93. [Full Text/Abstract]
Young JM, Badgery-Parker T, Masya LM, King M, Koh C, Lynch AC, Heriot AG, Solomon MJ. Quality of life and other patient-reported outcomes following exenteration for pelvic malignancy. Br J Surg. 2014 Feb; 101 (101; 2014 Feb; 3):277-87. [Full Text/Abstract]
Chen KL, Chen CT, Chou YT, Shih CL, Koh CL, Hsieh CL. Is the Long Form of the Fugl-Meyer Motor Scale More Responsive Than the Short Form in Patients With Stroke?. Arch Phys Med Rehabil. [Full Text/Abstract]
Kaneyama T, Tomiki H, Tsugane S, Inaba Y, Ichikawa M, Akiba H, Yagita H, Kim BS, Koh CS. The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease. Int Immunol. [Full Text/Abstract]
Tonsomboon K, Koh CT, Oyen ML. Time-dependent fracture toughness of cornea. J Mech Behav Biomed Mater. 34C (34C):116-123. [Full Text/Abstract]
Chow WZ, Takebe Y, Syafina NE, Prakasa MS, Chan KG, Al-Darraji HA, Koh C, Kamarulzaman A, Tee KK. A newly emerging HIV-1 recombinant lineage (CRF58_01B) disseminating among people who inject drugs in Malaysia. PLoS One. 2014; 9 (2014; 9; 1):e85250. [Full Text/Abstract]
Lee JH, Koh CY, Singer JP, Jeon SJ, Maldovan M, Stein O, Thomas EL. 25th anniversary article: ordered polymer structures for the engineering of photons and phonons. Adv Mater. 26 (4; 26):532-69. [Full Text/Abstract]
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C. Gut. 2014 Jan; 63 (2014 Jan; 63; 1):161-9. [Full Text/Abstract]
Gilchrist EJ, Sidebottom CH, Koh CS, Macinnes T, Sharpe AG, Haughn GW. A mutant Brassica napus (canola) population for the identification of new genetic diversity via TILLING and next generation sequencing. PLoS One. 20 Dec 2013; 8 (8; 12; 20 Dec 2013):e84303. [Full Text/Abstract]
Koh C, Zhao X, Samala N, Sakiani S, Liang TJ, Talwalkar JA. AASLD clinical practice guidelines: A critical review of scientific evidence and evolving recommendations. Hepatology. 2013 Dec; 58 (6; 2013 Dec; 58):2142-52. [Full Text/Abstract]
Koh C, Turner T, Zhao X, Minniti CP, Feld JJ, Simpson J, Demino M, Conrey AK, Jackson MJ, Seamon C, Kleiner DE, Kato GJ, Heller T. Liver stiffness increases acutely during sickle cell vaso-occlusive crisis. Am J Hematol. 2013 Nov; 88 (2013 Nov; 11; 88):E250-4. [Full Text/Abstract]
Hara K, Rivera MM, Koh C, Sakiani S, Hoofnagle JH, Heller T. Important factors in reliable determination of hepatitis C virus genotype by use of the 5' untranslated region. J Clin Microbiol. 2013 May; 51 (2013 May; 5; 51):1485-9. [Full Text/Abstract]
Koh C, Heller T, Haynes-Williams V, Hara K, Zhao X, Feld JJ, Kleiner DE, Rotman Y, Ghany MG, Liang TJ, Hoofnagle JH. Long-term outcome of chronic hepatitis C after sustained virological response to interferon-based therapy. Aliment Pharmacol Ther. 2013 May; 37 (2013 May; 37; 9):887-94. [Full Text/Abstract]
Oppenheimer AP, Koh C, McLaughlin M, Williamson JC, Norton TD, Laudadio J, Heller T, Kleiner DE, High KP, Morse CG. Vanishing bile duct syndrome in human immunodeficiency virus infected adults: a report of two cases. World J Gastroenterol. 2013 Jan 7; 19 (19; 2013 Jan 7; 1):115-21. [Full Text/Abstract]
Eccleston JL, Koh C, Markello TC, Gahl WA, Heller T. An apparent homozygous deletion in maltase-glucoamylase, a lesson in the evolution of SNP arrays. Mol Genet Metab. 2012 Dec; 107 (2012 Dec; 107; 4):674-8. [Full Text/Abstract]
Ghany MG, Feld JJ, Zhao X, Heller T, Doo E, Rotman Y, Nagabhyru P, Koh C, Kleiner DE, Wright EC, Liang TJ, Hoofnagle JH. Randomised clinical trial: the benefit of combination therapy with adefovir and lamivudine for chronic hepatitis B. Aliment Pharmacol Ther. 2012 May; 35 (2012 May; 35; 9):1027-35. [Full Text/Abstract]
Sandler NG, Koh C, Roque A, Eccleston JL, Siegel RB, Demino M, Kleiner DE, Deeks SG, Liang TJ, Heller T, Douek DC. Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection. Gastroenterology. 2011 Oct; 141 (4; 141; 2011 Oct):1220-30, 1230.e1-3. [Full Text/Abstract]
Feld JJ, Modi AA, El-Diwany R, Rotman Y, Thomas E, Ahlenstiel G, Titerence R, Koh C, Cherepanov V, Heller T, Ghany MG, Park Y, Hoofnagle JH, Liang TJ. S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders. Gastroenterology. 2011 Mar; 140 (2011 Mar; 140; 3):830-9. [Full Text/Abstract]
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, NASH CRN. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology. 2010 Sep; 52 (2010 Sep; 3; 52):894-903. [Full Text/Abstract]
Feld JJ, Lutchman GA, Heller T, Hara K, Pfeiffer JK, Leff RD, Meek C, Rivera M, Ko M, Koh C, Rotman Y, Ghany MG, Haynes-Williams V, Neumann AU, Liang TJ, Hoofnagle JH. Ribavirin improves early responses to peginterferon through improved interferon signaling. Gastroenterology. 2010 Jul; 139 (2010 Jul; 139; 1):154-62.e4. [Full Text/Abstract]