U.S. Department of Health and Human Services
Chuxia Deng

 Contact Info

Tel: 301-402-7225
Email: chuxia.deng@nih.gov

 Select Experience

  • Ph.D.University of Utah1992
  • M.S.Institute of Hydrobiology, Chinese Academy of Science1984
  • B.S.Nanchong Normal University1981

 Related Links


    • Cancer Biology
    • Chromosome Biology/Epigenetics
    • Developmental Biology
    • Genetics/Genomics
    • Molecular Biology/Biochemistry
    • Stem Cells/Induced Pluripotent Stem Cells


    Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.

    Resource Name Description
    Smad4 LoxP Mouse (Mutant Mouse: Smad4)

    Smad4 conditional KO.  Inactivation of LoxP-flanked Smad 4 makes it possible to explore the role of Smad 4 in embryonic development of different tissues and in tumorigenesis.

    Members of the TGF-b superfamily (which includes Bone Morphogenic Protein…

    FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation. (Mutant Mouse: Fgfr2 KO (Fgfr2 tm1Cxd) Mouse)

    FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation.

    Fibroblast Growth Factor Receptor 2 (FGFR2) is a high affinity receptor for several members of the FGF family.  The FGFR2 gene was inactivated by deleting the entire…

    Smad4 KO (Smad4 tm1Cxd) Mouse (Mutant Mouse: Smad4)

    Smad4 knockout: Smad 4 is essential for epiblast proliferation and mesoderm induction in early embryogenesis.

    The TGF-β-related superfamily plays an important role in multiple biological systems including embryogenesis.  TGF-β ligands activate…

    Sirt1 LoxP (Sirt1 tm1Cxd) Mouse (Mutant Mouse: Sirt1)

    Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice

    Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and protein deacetylase.  It has a wide range of biological functions, ranging from…

    Sirt6 LoxP (Sirt6 tm1.1Cxd) Mouse (Mutant Mouse: Sirt6)

    Generation of floxed Sirtuin 6 for the construction of conditional knockout mice

    The Sirtuins (Sirt1-7), a family of seven proteins related to yeast Sir2, are histone deacetylases that regulate many critical biological processes including genomic…

    Smad3 KO (Smad3 tm1Cxd) Mouse (Mutant Mouse: Smad3 (MAD homolog 3 (Drosophila)))

    Smad 3 knockout: Increased susceptibility to opportunistic infections and massive abscesses result from impaired TGF-β-mediated regulation of T cell activation and mucosal immunity.

    Smad3 is one of the intracellular mediators that transduce signals…

    Brca1(Brca1tm1Cxd) Mouse (Mutant Mouse: Brca1 (Breast cancer1))

    Knockout of the BRCA1 (Breast Cancer 1) gene impairs DNA damage repair resulting in embryonic death.

    Germ-line mutations of the nuclear protein BRCA1 are responsible for increased susceptibility to familial breast and ovarian cancers.  Targeted…

    Brca1 LoxP Mouse (Mutant Mouse: Brca1 (Breast cancer1))

    BRCA1 conditional knockouts.  BRCA1 LoxP mutations allow selective inactivation of the gene in mammary epithelial cells (accelerating breast tumor formation) and in cardiomyocytes (impairing cardiac remodeling that may increase the risk of heart…

    Sirt1 KO (Sirt1 tm1.1Cxd) Mouse (Mutant Mouse: Sirt1 (sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae))

    Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.

    Yeast Sir2, a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, has been…

    Sirt3 KO (Sirt3 tm1.1Cxd) Mouse (Mutant Mouse: Sirt3)

    Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.

    SirT3 is a mitochondrial protein that is a member of the Sirtuin family of NAD-dependent protein deacetylases…

    View Additional Research Resources

    Clinical Trials

    Open studies conducted by NIDDK Principal Investigators appear below that are currently recruiting, not yet recruiting, or available for expanded access.

    Study Title
    There are no associated clinical trials.
    Search for more clinical trials at ClinicalTrials.gov