U.S. Department of Health and Human Services
Clifton Bogardus III

 Contact Info

Tel: 602-200-5200
Email: clifton_bogardus@nih.gov

 Select Experience

  • ChiefPhoenix Epidemiology and Clinical Research Branch, NIDDK, NIH2000–present
  • ChiefClinical Diabetes and Nutrition Section, NIDDK, NIH1985–2000
  • NIH Clinical Research Training FellowshipUniversity of Vermont1979–1982
  • Internal Medicine ResidencyDartmouth - Hitchcock Medical Center1977–1979
  • CommanderU.S. Army Health Clinic1975–1977
  • Internal Medicine InternshipDartmouth - Hitchcock Medical Center1974–1975
  • M.D.University of Rochester School of Medicine1974
  • B.S.Lafayette College1970

 Related Links


    • Clinical Research
    • Endocrinology
    • Epidemiology/Population Sciences
    • Genetics/Genomics
    • Health Disparities


    A selection of recent and significant publications can be viewed below.

    Muller YL, Piaggi P, Hoffman D, Huang K, Gene B, Kobes S, Thearle MS, Knowler WC, Hanson RL, Baier LJ, Bogardus C. Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure. Diabetologia. 2014 Jul; 57 (7; 2014 Jul; 57):1382-90. [Full Text/Abstract]
    Del Rosario MC, Ossowski V, Knowler WC, Bogardus C, Baier LJ, Hanson RL. Potential epigenetic dysregulation of genes associated with MODY and type 2 diabetes in humans exposed to a diabetic intrauterine environment: An analysis of genome-wide DNA methylation. Metabolism. 2014 May; 63 (2014 May; 63; 5):654-60. [Full Text/Abstract]
    Huang K, Nair AK, Muller YL, Piaggi P, Bian L, Del Rosario M, Knowler WC, Kobes S, Hanson RL, Bogardus C, Baier LJ. Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes. Obesity (Silver Spring). 2014 Apr; 22 (4; 2014 Apr; 22):984-8. [Full Text/Abstract]
    Hanson RL, Muller YL, Kobes S, Guo T, Bian L, Ossowski V, Wiedrich K, Sutherland J, Wiedrich C, Mahkee D, Huang K, Abdussamad M, Traurig M, Weil EJ, Nelson RG, Bennett PH, Knowler WC, Bogardus C, Baier LJ. A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes. Diabetes. 2014 Jan; 63 (2014 Jan; 63; 1):369-76. [Full Text/Abstract]
    Thearle MS, Muller YL, Hanson RL, Mullins M, Abdussamad M, Tran J, Knowler WC, Bogardus C, Krakoff J, Baier LJ. Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians. Diabetes. 2012 Jan; 61 (1; 2012 Jan; 61):250-7. [Full Text/Abstract]
    Malhotra A, Kobes S, Knowler WC, Baier LJ, Bogardus C, Hanson RL. A genome-wide association study of BMI in American Indians. Obesity (Silver Spring). 2011 Oct; 19 (19; 2011 Oct; 10):2102-6. [Full Text/Abstract]
    Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI, Krakoff J. Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr. 2011 Jul; 94 (94; 2011 Jul; 1):58-65. [Full Text/Abstract]
    Mason CC, Hanson RL, Ossowski V, Bian L, Baier LJ, Krakoff J, Bogardus C. Bimodal distribution of RNA expression levels in human skeletal muscle tissue. BMC Genomics. 2011 Feb 7; 12 (2011 Feb 7; 12):98. [Full Text/Abstract]
    Ma L, Hanson RL, Traurig MT, Muller YL, Kaur BP, Perez JM, Meyre D, Fu M, Körner A, Franks PW, Kiess W, Kobes S, Knowler WC, Kovacs P, Froguel P, Shuldiner AR, Bogardus C, Baier LJ. Evaluation of A2BP1 as an obesity gene. Diabetes. 2010 Nov; 59 (2010 Nov; 59; 11):2837-45. [Full Text/Abstract]
    Penesova A, Bunt JC, Bogardus C, Krakoff J. Effect of paternal diabetes on pre-diabetic phenotypes in adult offspring. Diabetes Care. 2010 Aug; 33 (8; 33; 2010 Aug):1823-8. [Full Text/Abstract]
    Bian L, Hanson RL, Ossowski V, Wiedrich K, Mason CC, Traurig M, Muller YL, Kobes S, Knowler WC, Baier LJ, Bogardus C. Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians. Diabetes. 2010 May; 59 (2010 May; 59; 5):1276-82. [Full Text/Abstract]
    Traurig M, Mack J, Hanson RL, Ghoussaini M, Meyre D, Knowler WC, Kobes S, Froguel P, Bogardus C, Baier LJ. Common variation in SIM1 is reproducibly associated with BMI in Pima Indians. Diabetes. 2009 Jul; 58 (7; 58; 2009 Jul):1682-9. [Full Text/Abstract]
    Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, Hattersley AT, Hu C, Morris AD, Ng M, Palmer CN, Tello-Ruiz M, Vaxillaire M, Wang CR, Stein L, Chan J, Jia W, Froguel P, Elbein SC, Deloukas P, Bogardus C, Shuldiner AR, McCarthy MI, International Type 2 Diabetes 1q Consortium. Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. Diabetes. 2009 Jul; 58 (7; 58; 2009 Jul):1704-9. [Full Text/Abstract]
    Rong R, Hanson RL, Ortiz D, Wiedrich C, Kobes S, Knowler WC, Bogardus C, Baier LJ. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes. 2009 Feb; 58 (2009 Feb; 2; 58):478-88. [Full Text/Abstract]
    Krakoff J, Ma L, Kobes S, Knowler WC, Hanson RL, Bogardus C, Baier LJ. Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant. Diabetes. 2008 Dec; 57 (2008 Dec; 12; 57):3267-72. [Full Text/Abstract]
    Thameem F, Farook VS, Yang X, Lee YH, Permana PA, Bogardus C, Prochazka M. The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians. Mol Genet Metab. 2004 Jan; 81 (81; 2004 Jan; 1):16-21. [Full Text/Abstract]
    Muller YL, Bogardus C, Beamer BA, Shuldiner AR, Baier LJ. A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians. Diabetes. 2003 Jul; 52 (7; 2003 Jul; 52):1864-71. [Full Text/Abstract]
    Muller YL, Bogardus C, Pedersen O, Baier L. A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes. 2003 Mar; 52 (2003 Mar; 3; 52):895-8. [Full Text/Abstract]