U.S. Department of Health and Human Services
Constance Tom Noguchi

 Contact Info

Tel: 301-496-1163
Email: cnoguchi@helix.nih.gov

 Select Experience

  • Ph.D.The George Washington University1975
  • B.A.University of California, Berkeley1970

 Related Links


    Constance Tom Noguchi, Ph.D.

    Section Chief, Molecular Cell Biology SectionMolecular Medicine Branch
    • Cell Biology/Cell Signaling


    A selection of recent and significant publications can be viewed below.

    Wang L, Di L, Noguchi CT. AMPK is Involved in Mediation of Erythropoietin Influence on Metabolic Activity and Reactive Oxygen Species Production in White Adipocytes. Int J Biochem Cell Biol. 2014 Jun 19; 54 (2014 Jun 19; 54):1-9. [Full Text/Abstract]
    Wang X, Mendelsohn L, Rogers H, Leitman S, Raghavachari N, Yang Y, Yau YY, Tallack M, Perkins A, Taylor JG 6th, Noguchi CT, Kato GJ. Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor. Blood. 2014 Aug 7; 124 (124; 6; 2014 Aug 7):946-54. [Full Text/Abstract]
    Alnaeeli M, Raaka BM, Gavrilova O, Teng R, Chanturiya T, Noguchi CT. Erythropoietin signaling: A novel regulator of white adipose tissue inflammation during diet-induced obesity. Diabetes. 2014 Jul; 63 (7; 63; 2014 Jul):2415-31. [Full Text/Abstract]
    Zhang Y, Wang L, Dey S, Alnaeeli M, Suresh S, Rogers H, Teng R, Noguchi CT. Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism. Int J Mol Sci. 2014 Jun 10; 15 (6; 15; 2014 Jun 10):10296-10333. [Full Text/Abstract]
    Cokic BB, Cokic VP, Suresh S, Wirt S, Noguchi CT. Nitric oxide and hypoxia stimulate erythropoietin receptor via MAPK kinase in endothelial cells. Microvasc Res. 2014 Mar; 92 (2014 Mar; 92):34-40. [Full Text/Abstract]
    Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT. T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis. J Biol Chem. 2012 Oct 26; 287 (287; 2012 Oct 26; 44):36720-31. [Full Text/Abstract]
    Wang L, Jia Y, Rogers H, Wu YP, Huang S, Noguchi CT. GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1). J Biol Chem. 2012 Aug 31; 287 (287; 36; 2012 Aug 31):30157-69. [Full Text/Abstract]
    Jia Y, Suzuki N, Yamamoto M, Gassmann M, Noguchi CT. Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage. FASEB J. 2012 Jul; 26 (7; 2012 Jul; 26):2847-58. [Full Text/Abstract]
    Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, Mammen S, Yver DR, Cushman SW, Mueller E, Yamamoto M, Hsu LL, Noguchi CT. Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production. Nat Commun. 2011 Nov 1; 2 (2; 2011 Nov 1):520. [Full Text/Abstract]
    Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT. Acute erythropoietin cardioprotection is mediated by endothelial response. Basic Res Cardiol. 2011 May; 106 (106; 3; 2011 May):343-54. [Full Text/Abstract]
    Jia Y, Warin R, Yu X, Epstein R, Noguchi CT. Erythropoietin signaling promotes transplanted progenitor cell survival. FASEB J. 2009 Sep; 23 (23; 9; 2009 Sep):3089-99. [Full Text/Abstract]
    Noguchi CT, Wang L, Rogers HM, Teng R, Jia Y. Survival and proliferative roles of erythropoietin beyond the erythroid lineage. Expert Rev Mol Med. 2008 Dec 1; 10 (2008 Dec 1; 10):e36. [Full Text/Abstract]
    Cokic VP, Andric SA, Stojilkovic SS, Noguchi CT, Schechter AN. Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells. Blood. 2008 Feb 1; 111 (111; 3; 2008 Feb 1):1117-23. [Full Text/Abstract]
    Rogers HM, Yu X, Wen J, Smith R, Fibach E, Noguchi CT. Hypoxia alters progression of the erythroid program. Exp Hematol. 2008 Jan; 36 (2008 Jan; 36; 1):17-27. [Full Text/Abstract]
    Chen ZY, Asavaritikrai P, Prchal JT, Noguchi CT. Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation. J Biol Chem. 2007 Aug 31; 282 (35; 282; 2007 Aug 31):25875-83. [Full Text/Abstract]
    Hsu LL, Champion HC, Campbell-Lee SA, Bivalacqua TJ, Manci EA, Diwan BA, Schimel DM, Cochard AE, Wang X, Schechter AN, Noguchi CT, Gladwin MT. Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood. 2007 Apr 1; 109 (109; 7; 2007 Apr 1):3088-98. [Full Text/Abstract]
    Cokic VP, Beleslin-Cokic BB, Tomic M, Stojilkovic SS, Noguchi CT, Schechter AN. Hydroxyurea induces the eNOS-cGMP pathway in endothelial cells. Blood. 2006 Jul 1; 108 (108; 2006 Jul 1; 1):184-91. [Full Text/Abstract]
    Wen J, Huang S, Rogers H, Dickinson LA, Kohwi-Shigematsu T, Noguchi CT. SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression. Blood. 2005 Apr 15; 105 (105; 2005 Apr 15; 8):3330-9. [Full Text/Abstract]
    Wen J, Huang S, Pack SD, Yu X, Brandt SJ, Noguchi CT. Tal1/SCL binding to pericentromeric DNA represses transcription. J Biol Chem. 2005 Apr 1; 280 (280; 13; 2005 Apr 1):12956-66. [Full Text/Abstract]
    Beleslin-Cokic BB, Cokic VP, Yu X, Weksler BB, Schechter AN, Noguchi CT. Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. Blood. 2004 Oct 1; 104 (104; 2004 Oct 1; 7):2073-80. [Full Text/Abstract]
    Yu X, Shacka JJ, Eells JB, Suarez-Quian C, Przygodzki RM, Beleslin-Cokic B, Lin CS, Nikodem VM, Hempstead B, Flanders KC, Costantini F, Noguchi CT. Erythropoietin receptor signalling is required for normal brain development. Development. 2002 Jan; 129 (2; 129; 2002 Jan):505-16. [Full Text/Abstract]