U.S. Department of Health and Human Services
Daniel Appella

 Contact Info

Tel: 301-451-1052
Email: appellad@niddk.nih.gov

 Select Experience

  • Assistant ProfessorNorthwestern University2001-2004
  • Postdoctoral FellowMassachusetts Institute of Technology1998 – 2001
  • Ph.D.University of Wisconsin-Madison1998

 Related Links

  • Chemistry/Chemical Biology


A selection of recent and significant publications can be viewed below.

Zhao C, Hoppe T, Setty MK, Murray D, Chun TW, Hewlett I, Appella DH. Quantification of plasma HIV RNA using chemically engineered peptide nucleic acids. Nat Commun. 2014 Oct 6; 5 (2014 Oct 6; 5):5079. [Full Text/Abstract]
Englund EA, Gupta P, Micklitsch CM, Onyshchenko MI, Remeeva E, Neumann RD, Panyutin IG, Appella DH. PPG peptide nucleic acids that promote DNA guanine quadruplexes. Chembiochem. 2014 Jul 8; 15 (15; 13; 2014 Jul 8):1887-90. [Full Text/Abstract]
Dix AV, Moss SM, Phan K, Hoppe T, Paoletta S, Kozma E, Gao ZG, Durell SR, Jacobson KA, Appella DH. Programmable Nanoscaffolds That Control Ligand Display to a G-Protein-Coupled Receptor in Membranes To Allow Dissection of Multivalent Effects. J Am Chem Soc. 2014 Aug 25; 136 (35; 2014 Aug 25; 136):12296-303. [Full Text/Abstract]
Englund EA, Zhang N, Appella DH. Cyclopentane peptide nucleic acids. Methods Mol Biol. 2014; 1050 (2014; 1050):13-8. [Full Text/Abstract]
Micklitsch CM, Oquare BY, Zhao C, Appella DH. Cyclopentane-peptide nucleic acids for qualitative, quantitative, and repetitive detection of nucleic acids. Anal Chem. 2013 Jan 2; 85 (85; 2013 Jan 2; 1):251-7. [Full Text/Abstract]
Kumar S, Kellish P, Robinson WE Jr, Wang D, Appella DH, Arya DP. Click dimers to target HIV TAR RNA conformation. Biochemistry. 2012 Mar 20; 51 (2012 Mar 20; 51; 11):2331-47. [Full Text/Abstract]
Englund EA, Wang D, Fujigaki H, Sakai H, Micklitsch CM, Ghirlando R, Martin-Manso G, Pendrak ML, Roberts DD, Durell SR, Appella DH. Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds. Nat Commun. 2012 Jan 10; 3 (2012 Jan 10; 3):614. [Full Text/Abstract]
Pokorski JK, Appella DH. Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA. J Nucleic Acids. 2012; 2012 (2012):971581. [Full Text/Abstract]
Panyutin IG, Onyshchenko MI, Englund EA, Appella DH, Neumann RD. Targeting DNA G-quadruplex structures with peptide nucleic acids. Curr Pharm Des. 2012; 18 (2012; 14; 18):1984-91. [Full Text/Abstract]
Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG. Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region. Nucleic Acids Res. 2011 Sep 1; 39 (16; 39; 2011 Sep 1):7114-23. [Full Text/Abstract]
Bahde RJ, Appella DH, Trenkle WC. A one-pot preparation of N-2-mercaptobenzoyl-amino amides. Tetrahedron Lett. 2011 Aug 10; 52 (32; 2011 Aug 10; 52):4103-4105. [Full Text/Abstract]
Macadangdang B, Zhang N, Lund PE, Marple AH, Okabe M, Gottesman MM, Appella DH, Kimchi-Sarfaty C. Inhibition of multidrug resistance by SV40 pseudovirion delivery of an antigene peptide nucleic acid (PNA) in cultured cells. PLoS One. 2011 Mar 22; 6 (6; 2011 Mar 22; 3):e17981. [Full Text/Abstract]
Englund EA, Appella DH. Gamma-substituted peptide nucleic acids constructed from L-lysine are a versatile scaffold for multifunctional display. Angew Chem Int Ed Engl. 2007; 46 (46; 9; 2007):1414-8. [Full Text/Abstract]
Englund EA, Xu Q, Witschi MA, Appella DH. PNA-DNA duplexes, triplexes, and quadruplexes are stabilized with trans-cyclopentane units. J Am Chem Soc. 2006 Dec 27; 128 (128; 2006 Dec 27; 51):16456-7. [Full Text/Abstract]
Xu Q, Appella DH. Practical synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate and resolution of enantiomers. J Org Chem. 2006 Oct 27; 71 (71; 2006 Oct 27; 22):8655-7. [Full Text/Abstract]
Hara T, Durell SR, Myers MC, Appella DH. Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions. J Am Chem Soc. 2006 Feb 15; 128 (128; 2006 Feb 15; 6):1995-2004. [Full Text/Abstract]
Myers MC, Wang J, Iera JA, Bang JK, Hara T, Saito S, Zambetti GP, Appella DH. A new family of small molecules to probe the reactivation of mutant p53. J Am Chem Soc. 2005 May 4; 127 (127; 17; 2005 May 4):6152-3. [Full Text/Abstract]
Pokorski JK, Nam JM, Vega RA, Mirkin CA, Appella DH. Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection. Chem Commun (Camb). 2005 Apr 28; (16; 2005 Apr 28):2101-3. [Full Text/Abstract]
Lawton GR, Appella DH. Nonionic side chains modulate the affinity and specificity of binding between functionalized polyamines and structured RNA. J Am Chem Soc. 2004 Oct 13; 126 (2004 Oct 13; 126; 40):12762-3. [Full Text/Abstract]