U.S. Department of Health and Human Services
Daniel Appella
 

 Contact Info

 
Tel: 301-451-1052
Email: appellad@niddk.nih.gov
 

 Select Experience

 
  • Assistant ProfessorNorthwestern University2001-2004
  • Postdoctoral FellowMassachusetts Institute of Technology1998 – 2001
  • Ph.D.University of Wisconsin-Madison1998
 

 Related Links

 

    Daniel Appella, Ph.D.

    Senior Investigator, Laboratory of Bioorganic ChemistrySynthetic Bioactive Molecules Section
    Specialties
    • Chemistry/Chemical Biology

    Research in Plain Language

    Our lab designs and makes new molecules that may help diagnose or treat human diseases. We use organic chemistry to create new types of molecules with interesting biological activity. With other scientists, we study how these molecules function in living organisms.

    We focus on a few specific classes of molecules. We mainly design and make a type of molecule called a peptide nucleic acid (PNA). This is an artificial nucleic acid. PNA shares some characteristics with the naturally occurring nucleic acids DNA and RNA. However, the PNA chemical backbone is different.

    We have modified PNA chemistry to increase their usefulness in medicine. For example, we created one PNA that might improve disease diagnosis. We use another chemically modified PNA to study how cells communicate over large surface areas. In addition to PNA, we also design and make molecules that may become future medicines. We develop unique classes of molecules that represent new approaches to the treatment of HIV and cancer.