U.S. Department of Health and Human Services
Deborah Hinton

 Contact Info

Tel: 301-496-9885
Email: dhinton@helix.nih.gov

 Select Experience

  • Ph.D.University of Illinois1980
  • M.S.University of Illinois1976
  • B.S.University of North Carolina at Chapel Hill1974

 Related Links


    • Molecular Biology/Biochemistry


    A selection of recent and significant publications can be viewed below.

    Chen Q, Boulanger A, Hinton DM, Stibitz S. Strong inhibition of fimbrial 3 subunit gene transcription by a novel downstream repressive element in Bordetella pertussis. Mol Microbiol. 2014 Aug; 93 (93; 2014 Aug; 4):748-58. [Full Text/Abstract]
    Palencia ER, Mitchell TR, Snook ME, Glenn AE, Gold S, Hinton DM, Riley RT, Bacon CW. Analyses of Black Aspergillus Species of Peanut and Maize for Ochratoxins and Fumonisins. J Food Prot. 2014 May; 77 (77; 2014 May; 5):805-813. [Full Text/Abstract]
    Decker KB, James TD, Stibitz S, Hinton DM. The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA. Microbiology. 2012 Jul; 158 (Pt 7; 2012 Jul; 158):1665-76. [Full Text/Abstract]
    Dolezal D, Jones CE, Lai X, Brister JR, Mueser TC, Nossal NG, Hinton DM. Mutational analysis of the T4 gp59 helicase loader reveals its sites for interaction with helicase, single-stranded binding protein, and DNA. J Biol Chem. 2012 May 25; 287 (2012 May 25; 287; 22):18596-607. [Full Text/Abstract]
    Bonocora RP, Decker PK, Glass S, Knipling L, Hinton DM. Bacteriophage T4 MotA activator and the β-flap tip of RNA polymerase target the same set of σ70 carboxyl-terminal residues. J Biol Chem. 2011 Nov 11; 286 (2011 Nov 11; 45; 286):39290-6. [Full Text/Abstract]
    Decker KB, Chen Q, Hsieh ML, Boucher P, Stibitz S, Hinton DM. Different requirements for σ Region 4 in BvgA activation of the Bordetella pertussis promoters P(fim3) and P(fhaB). J Mol Biol. 2011 Jun 24; 409 (2011 Jun 24; 409; 5):692-709. [Full Text/Abstract]
    James TD, Cashel M, Hinton DM. A mutation within the β subunit of Escherichia coli RNA polymerase impairs transcription from bacteriophage T4 middle promoters. J Bacteriol. 2010 Nov; 192 (2010 Nov; 21; 192):5580-7. [Full Text/Abstract]
    Hinton DM. Transcriptional control in the prereplicative phase of T4 development. Virol J. 2010 Oct 28; 7 (7; 2010 Oct 28):289. [Full Text/Abstract]
    Chen Q, Decker KB, Boucher PE, Hinton D, Stibitz S. Novel architectural features of Bordetella pertussis fimbrial subunit promoters and their activation by the global virulence regulator BvgA. Mol Microbiol. 2010 Sep; 77 (77; 2010 Sep; 5):1326-40. [Full Text/Abstract]
    Hook-Barnard IG, Hinton DM. The promoter spacer influences transcription initiation via sigma70 region 1.1 of Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A. 2009 Jan 20; 106 (106; 2009 Jan 20; 3):737-42. [Full Text/Abstract]
    Bonocora RP, Caignan G, Woodrell C, Werner MH, Hinton DM. A basic/hydrophobic cleft of the T4 activator MotA interacts with the C-terminus of E.coli sigma70 to activate middle gene transcription. Mol Microbiol. 2008 Jul; 69 (69; 2; 2008 Jul):331-43. [Full Text/Abstract]
    Hook-Barnard I, Johnson XB, Hinton DM. Escherichia coli RNA polymerase recognition of a sigma70-dependent promoter requiring a -35 DNA element and an extended -10 TGn motif. J Bacteriol. 2006 Dec; 188 (188; 2006 Dec; 24):8352-9. [Full Text/Abstract]
    Baxter K, Lee J, Minakhin L, Severinov K, Hinton DM. Mutational analysis of sigma70 region 4 needed for appropriation by the bacteriophage T4 transcription factors AsiA and MotA. J Mol Biol. 2006 Nov 10; 363 (363; 2006 Nov 10; 5):931-44. [Full Text/Abstract]
    Hinton DM, Vuthoori S, Mulamba R. The bacteriophage T4 inhibitor and coactivator AsiA inhibits Escherichia coli RNA Polymerase more rapidly in the absence of sigma70 region 1.1: evidence that region 1.1 stabilizes the interaction between sigma70 and core. J Bacteriol. 2006 Feb; 188 (2006 Feb; 188; 4):1279-85. [Full Text/Abstract]