U.S. Department of Health and Human Services
Douglas Forrest

 Contact Info

Tel: 301-594-6170
Email: df189j@nih.gov

 Select Experience

  • Senior InvestigatorNIDDK, NIH2004
  • Associate ProfessorMount Sinai School of Medicine, Department of Human Genetics1995–2004
  • Ph.D.Glasgow University1987

 Related Links

  • Developmental Biology
  • Endocrinology
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Neuroscience/Neurophysiology/Neurodevelopment


A selection of recent and significant publications can be viewed below.

Fu Y, Liu H, Ng L, Kim JW, Hao H, Swaroop A, Forrest D. Feedback Induction of a Photoreceptor-specific Isoform of Retinoid-related Orphan Nuclear Receptor β by the Rod Transcription Factor NRL. J Biol Chem. 2014 Oct 7; 289 (289; 2014 Oct 7; 47):32469-80. [Full Text/Abstract]
Ng L, Kelley MW, Forrest D. Making sense with thyroid hormone--the role of T(3) in auditory development. Nat Rev Endocrinol. 2013 May; 9 (2013 May; 9; 5):296-307. [Full Text/Abstract]
Peeters RP, Hernandez A, Ng L, Ma M, Sharlin DS, Pandey M, Simonds WF, St Germain DL, Forrest D. Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1. Endocrinology. 2013 Jan; 154 (1; 2013 Jan; 154):550-61. [Full Text/Abstract]
Liu H, Kim SY, Fu Y, Wu X, Ng L, Swaroop A, Forrest D. An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons. Nat Commun. 2013; 4 (4; 2013):1813. [Full Text/Abstract]
Forrest D, Swaroop A. Minireview: the role of nuclear receptors in photoreceptor differentiation and disease. Mol Endocrinol. 2012 Jun; 26 (2012 Jun; 6; 26):905-15. [Full Text/Abstract]
Cordas EA, Ng L, Hernandez A, Kaneshige M, Cheng SY, Forrest D. Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones. Endocrinology. 2012 Mar; 153 (153; 2012 Mar; 3):1548-60. [Full Text/Abstract]
Sharlin DS, Visser TJ, Forrest D. Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea. Endocrinology. 2011 Dec; 152 (152; 12; 2011 Dec):5053-64. [Full Text/Abstract]
Alberobello AT, Congedo V, Liu H, Cochran C, Skarulis MC, Forrest D, Celi FS. An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormone. J Transl Med. 2011 Aug 26; 9 (2011 Aug 26; 9):144. [Full Text/Abstract]
Ng L, Lu A, Swaroop A, Sharlin DS, Swaroop A, Forrest D. Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development. J Neurosci. 2011 Aug 3; 31 (2011 Aug 3; 31):11118-25. [Full Text/Abstract]
Swaroop A, Kim D, Forrest D. Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina. Nat Rev Neurosci. 2010 Aug; 11 (8; 2010 Aug; 11):563-76. [Full Text/Abstract]
Ng L, Lyubarsky A, Nikonov SS, Ma M, Srinivas M, Kefas B, St Germain DL, Hernandez A, Pugh EN Jr, Forrest D. Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors. J Neurosci. 2010 Mar 3; 30 (2010 Mar 3; 30; 9):3347-57. [Full Text/Abstract]
Jia L, Oh EC, Ng L, Srinivas M, Brooks M, Swaroop A, Forrest D. Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A. 2009 Oct 13; 106 (106; 2009 Oct 13; 41):17534-9. [Full Text/Abstract]
Ng L, Hernandez A, He W, Ren T, Srinivas M, Ma M, Galton VA, St Germain DL, Forrest D. A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function. Endocrinology. 2009 Apr; 150 (2009 Apr; 150; 4):1952-60. [Full Text/Abstract]
Ng L, Goodyear RJ, Woods CA, Schneider MJ, Diamond E, Richardson GP, Kelley MW, Germain DL, Galton VA, Forrest D. Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci U S A. 2004 Mar 9; 101 (101; 2004 Mar 9; 10):3474-9. [Full Text/Abstract]
Ng L, Hurley JB, Dierks B, Srinivas M, Saltó C, Vennström B, Reh TA, Forrest D. A thyroid hormone receptor that is required for the development of green cone photoreceptors. Nat Genet. 2001 Jan; 27 (2001 Jan; 27; 1):94-8. [Full Text/Abstract]
Forrest D, Vennström B. Functions of thyroid hormone receptors in mice. Thyroid. 2000 Jan; 10 (2000 Jan; 10; 1):41-52. [Full Text/Abstract]
Göthe S, Wang Z, Ng L, Kindblom JM, Barros AC, Ohlsson C, Vennström B, Forrest D. Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation. Genes Dev. 1999 May 15; 13 (1999 May 15; 13; 10):1329-41. [Full Text/Abstract]
Forrest D, Erway LC, Ng L, Altschuler R, Curran T. Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet. 1996 Jul; 13 (1996 Jul; 13; 3):354-7. [Full Text/Abstract]
Sjöberg M, Vennström B, Forrest D. Thyroid hormone receptors in chick retinal development: differential expression of mRNAs for alpha and N-terminal variant beta receptors. Development. 1992 Jan; 114 (1992 Jan; 114; 1):39-47. [Full Text/Abstract]