U.S. Department of Health and Human Services
Elissa Lei
 

 Contact Info

 
Tel: 301-435-8989
Email: leielissa@mail.nih.gov
 

 Select Experience

 
  • Research and FounderIndependent Research Group, Laboratory of Cellular and Developmental Biology, NIDDK, NIH2006–Present
  • Postdoctoral ResearcherRNA Silencing and Chromatin Organization, Johns Hopkins University, Laboratory of Victor G. Corces2003–2006
  • Ph.D.Harvard Medical School, Laboratory of Pamela A. Silver2002
 

 Related Links

 

    Specialties
    • Cell Biology/Cell Signaling
    • Chromosome Biology/Epigenetics
    • Computational Biology/Bioinformatics/Biostatistics/Mathematics
    • Genetics/Genomics
    • Molecular Biology/Biochemistry

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Dale RK, Matzat LH, Lei EP. metaseq: a Python package for integrative genome-wide analysis reveals relationships between chromatin insulators and associated nuclear mRNA. Nucleic Acids Res. 2014 Oct 1; 42 (14):9158-70. [Full Text/Abstract]
    King MR, Matzat LH, Dale RK, Lim SJ, Lei EP. The RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner. J Cell Sci. 2014 Jul 1; 127 (Pt 13):2956-66. [Full Text/Abstract]
    Názer E, Lei EP. Modulation of chromatin modifying complexes by noncoding RNAs in trans. Curr Opin Genet Dev. 2014 Apr; 25 :68-73. [Full Text/Abstract]
    Lei EP. The regulation of gene expression is fundamental to development and disease. Introduction. Biochim Biophys Acta. 2014 Mar; 1839 (3):117. [Full Text/Abstract]
    Matzat LH, Lei EP. Surviving an identity crisis: A revised view of chromatin insulators in the genomics era. Biochim Biophys Acta. 2014 Mar; 1839 (3):203-14. [Full Text/Abstract]
    Matzat LH, Dale RK, Lei EP. Messenger RNA is a functional component of a chromatin insulator complex. EMBO Rep. 2013 Oct; 14 (10):916-22. [Full Text/Abstract]
    Ray D, Kazan H, Cook KB, Weirauch MT, Najafabadi HS, Li X, Gueroussov S, Albu M, Zheng H, Yang A, Na H, Irimia M, Matzat LH, Dale RK, Smith SA, Yarosh CA, Kelly SM, Nabet B, Mecenas D, Li W, Laishram RS, Qiao M, Lipshitz HD, Piano F, Corbett AH, Carstens RP, Frey BJ, Anderson RA, Lynch KW, Penalva LO, Lei EP, Fraser AG, Blencowe BJ, Morris QD, Hughes TR. A compendium of RNA-binding motifs for decoding gene regulation. Nature. 2013 Jul 11; 499 (7457):172-7. [Full Text/Abstract]
    Lim SJ, Boyle PJ, Chinen M, Dale RK, Lei EP. Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. Nucleic Acids Res. 2013 Mar 1; 41 (5):2963-80. [Full Text/Abstract]
    Matzat LH, Dale RK, Moshkovich N, Lei EP. Tissue-specific regulation of chromatin insulator function. PLoS Genet. 2012; 8 (11):e1003069. [Full Text/Abstract]
    Moshkovich N, Nisha P, Boyle PJ, Thompson BA, Dale RK, Lei EP. RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function. Genes Dev. 2011 Aug 15; 25 (16):1686-701. [Full Text/Abstract]
    Moshkovich N, Lei EP. HP1 recruitment in the absence of argonaute proteins in Drosophila. PLoS Genet. 2010 Mar 12; 6 (3):e1000880. [Full Text/Abstract]
    Gerasimova TI, Lei EP, Bushey AM, Corces VG. Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila. Mol Cell. 2007 Dec 14; 28 (5):761-72. [Full Text/Abstract]
    Caretti G, Lei EP, Sartorelli V. The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions. Cell Cycle. 2007 May 15; 6 (10):1172-6. [Full Text/Abstract]
    Lei EP, Corces VG. RNA interference machinery influences the nuclear organization of a chromatin insulator. Nat Genet. 2006 Aug; 38 (8):936-41. [Full Text/Abstract]
    Lei EP, Corces VG. A long-distance relationship between RNAi and Polycomb. Cell. 2006 Mar 10; 124 (5):886-8. [Full Text/Abstract]
    Pai CY, Lei EP, Ghosh D, Corces VG. The centrosomal protein CP190 is a component of the gypsy chromatin insulator. Mol Cell. 2004 Dec 3; 16 (5):737-48. [Full Text/Abstract]