U.S. Department of Health and Human Services
Marius Clore

 Contact Info

Tel: 301-496-0782
Email: mariusc@mail.nih.gov

 Select Experience

  • Ph.D.MRC National Institute for Medical Research, London1982
  • M.D.University College Hospital Medical School, London1979
  • B.Sc.University College London1976

 Related Links


G. Marius Clore, M.D., Ph.D., NIH Distinguished Investigator

Section Chief, Protein Nuclear Magnetic Resonance SectionLaboratory of Chemical Physics
  • Biomedical Engineering/Biophysics/Physics
  • Structural Biology


A selection of recent and significant publications can be viewed below.

Schwieters CD, Clore GM. Using small angle solution scattering data in Xplor-NIH structure calculations. Prog Nucl Magn Reson Spectrosc. 2014 Jul; 80C (80C; 2014 Jul):1-11. [Full Text/Abstract]
Kozakov D, Li K, Hall DR, Beglov D, Zheng J, Vakili P, Schueler-Furman O, Paschalidis ICh, Clore GM, Vajda S. Encounter complexes and dimensionality reduction in protein-protein association. Elife. 2014 Apr 8; 3 (3; 2014 Apr 8):e01370. [Full Text/Abstract]
Clore GM. Interplay between conformational selection and induced fit in multidomain protein-ligand binding probed by paramagnetic relaxation enhancement. Biophys Chem. 2014 Feb; 186 (186; 2014 Feb):3-12. [Full Text/Abstract]
Deshmukh L, Ghirlando R, Clore GM. Investigation of the structure and dynamics of the capsid-spacer peptide 1-nucleocapsid fragment of the HIV-1 gag polyprotein by solution NMR spectroscopy. Angew Chem Int Ed Engl. 2014 Jan 20; 53 (4; 53; 2014 Jan 20):1025-8. [Full Text/Abstract]
Deshmukh L, Schwieters CD, Grishaev A, Ghirlando R, Baber JL, Clore GM. Structure and dynamics of full-length HIV-1 capsid protein in solution. J Am Chem Soc. 2013 Oct 30; 135 (2013 Oct 30; 43; 135):16133-47. [Full Text/Abstract]
Libich DS, Fawzi NL, Ying J, Clore GM. Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR. Proc Natl Acad Sci U S A. 2013 Jul 9; 110 (28; 110; 2013 Jul 9):11361-6. [Full Text/Abstract]
Grishaev A, Anthis NJ, Clore GM. Contrast-matched small-angle X-ray scattering from a heavy-atom-labeled protein in structure determination: application to a lead-substituted calmodulin-peptide complex. J Am Chem Soc. 2012 Sep 12; 134 (134; 36; 2012 Sep 12):14686-9. [Full Text/Abstract]
Anthis NJ, Doucleff M, Clore GM. Transient, sparsely populated compact states of apo and calcium-loaded calmodulin probed by paramagnetic relaxation enhancement: interplay of conformational selection and induced fit. J Am Chem Soc. 2011 Nov 23; 133 (2011 Nov 23; 46; 133):18966-74. [Full Text/Abstract]
Fawzi NL, Ying J, Ghirlando R, Torchia DA, Clore GM. Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature. 2011 Oct 30; 480 (480; 2011 Oct 30; 7376):268-72. [Full Text/Abstract]
Takayama Y, Clore GM. Intra- and intermolecular translocation of the bi-domain transcription factor Oct1 characterized by liquid crystal and paramagnetic NMR. Proc Natl Acad Sci U S A. 2011 May 31; 108 (108; 22; 2011 May 31):E169-76. [Full Text/Abstract]
Schwieters CD, Suh JY, Grishaev A, Ghirlando R, Takayama Y, Clore GM. Solution structure of the 128 kDa enzyme I dimer from Escherichia coli and its 146 kDa complex with HPr using residual dipolar couplings and small- and wide-angle X-ray scattering. J Am Chem Soc. 2010 Sep 22; 132 (2010 Sep 22; 37; 132):13026-45. [Full Text/Abstract]
Fawzi NL, Doucleff M, Suh JY, Clore GM. Mechanistic details of a protein-protein association pathway revealed by paramagnetic relaxation enhancement titration measurements. Proc Natl Acad Sci U S A. 2010 Jan 26; 107 (107; 2010 Jan 26; 4):1379-84. [Full Text/Abstract]
Clore GM, Iwahara J. Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes. Chem Rev. 2009 Sep; 109 (109; 9; 2009 Sep):4108-39. [Full Text/Abstract]
Doucleff M, Clore GM. Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1. Proc Natl Acad Sci U S A. 2008 Sep 16; 105 (105; 2008 Sep 16; 37):13871-6. [Full Text/Abstract]
Tang C, Schwieters CD, Clore GM. Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR. Nature. 2007 Oct 25; 449 (449; 7165; 2007 Oct 25):1078-82. [Full Text/Abstract]
Tang C, Iwahara J, Clore GM. Visualization of transient encounter complexes in protein-protein association. Nature. 2006 Nov 16; 444 (2006 Nov 16; 7117; 444):383-6. [Full Text/Abstract]
Iwahara J, Zweckstetter M, Clore GM. NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. Proc Natl Acad Sci U S A. 2006 Oct 10; 103 (41; 2006 Oct 10; 103):15062-7. [Full Text/Abstract]
Iwahara J, Clore GM. Detecting transient intermediates in macromolecular binding by paramagnetic NMR. Nature. 2006 Apr 27; 440 (7088; 440; 2006 Apr 27):1227-30. [Full Text/Abstract]