U.S. Department of Health and Human Services
Marius Clore
 

 Contact Info

 
Tel: 301-496-0782
Email: mariusc@mail.nih.gov
 

 Select Experience

 
  • Ph.D.MRC National Institute for Medical Research, London1982
  • M.D.University College Hospital Medical School, London1979
  • B.Sc.University College London1976
 

 Related Links

 

G. Marius Clore, M.D., Ph.D., NIH Distinguished Investigator

Chief, Laboratory of Chemical PhysicsProtein Nuclear Magnetic Resonance Section
Specialties
  • Biomedical Engineering/Biophysics/Physics
  • Structural Biology

Research Summary

Research Goal

The purpose of my lab’s research is to understand the interrelationship between the structure, dynamics, and function of proteins.    

Current Research

Our lab studies the structure and dynamics of proteins, protein-protein complexes, and protein-nucleic acid complexes using multidimensional nuclear magnetic resonance (NMR) spectroscopy, and we develop and apply novel NMR and computational methods to aid in these studies.  We are particularly interested in complexes involved in signal transduction and transcriptional regulation, and on AIDS and AIDS-related proteins.  More recently we have focused on the development of novel NMR methods to detect, visualize, and characterize transient, sparsely populated states of macromolecules.  Such states, which are invisible to conventional biophysical techniques, including crystallography, play a critical role in macromolecular recognition, allostery induced fit, conformational selection, and molecular assembly.​

Applying our Research

This research will facilitate targeted and rational drug design.