U.S. Department of Health and Human Services
Gregory Germino
 

 Contact Info

 
Tel: 301-496-5877
Email: germinogg@mail.nih.gov
 

 Select Experience

 
  • Senior InvestigatorKidney Diseases Branch, NIDDK, NIH2009–Present
  • Adjunct Professor of MedicineJohns Hopkins University School of Medicine2009–Present
  • Professor of Medicine Division of Nephrology, Johns Hopkins University School of Medicine2003–2009
  • Affiliate MemberMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine2002–2009
  • Joint AppointmentDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine2001–2009
  • Associate Professor of MedicineDivision of Nephrology, Johns Hopkins University School of Medicine1997–2003
  • Assistant Professor of MedicineDivision of Nephrology, Johns Hopkins University School of Medicine1992–1997
  • Associate Research ScientistInstructor and Assistant Professor, Yale University School of Medicine1988–1992
  • Research Post-Doctoral FellowNuffield Department of Medicine, Oxford University1987–1988
  • Clinical Post-Doctoral FellowNephrology, Yale University School of Medicine1986–1987
  • Internal Medicine ResidencyYale–New Haven Hospital1983–1986
  • M.D.AOA, University of Chicago Pritzker School of Medicine1983
  • B.S.Loyola University of Chicago1979
 

 Related Links

 

    Gregory G. Germino, M.D.

    Deputy Director, Office of the Director​
    Senior Investigator, Kidney Diseases Branch, Polycystic Kidney Diseases Laboratory

    Specialties: Molecular Biology/Biochemistry, Genetics/Genomics, Nephrology​​

    Gregory G. Germino, M.D.

    Senior Investigator, Kidney Diseases BranchPolycystic Kidney Disease Laboratory
    Deputy Director, Office of the Director
    Deputy Director, Office of the Deputy Director
    Specialties
    • Genetics/Genomics
    • Molecular Biology/Biochemistry
    • Nephrology

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Pei Y, Lan Z, Wang K, Garcia-Gonzalez M, He N, Dicks E, Parfrey P, Germino G, Watnick T. A missense mutation in PKD1 attenuates the severity of renal disease. Kidney Int. 2012 Feb; 81:412-7. [Full Text/Abstract]
    Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Géléoc GS, Holt JR, Zuo J. Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. J. Neurosci. 2011 Aug 24; 31:12241-50. [Full Text/Abstract]
    Ferreira FM, Oliveira LC, Germino GG, Onuchic JN, Onuchic LF. Macromolecular assembly of polycystin-2 intracytosolic C-terminal domain. Proc. Natl. Acad. Sci. U.S.A. 2011 Jun 14; 108:9833-8. [Full Text/Abstract]
    Watnick T, Germino GG. mTOR inhibitors in polycystic kidney disease. N. Engl. J. Med. 2010 Aug 26; 363:879-81. [Full Text/Abstract]
    Shillingford JM, Piontek KB, Germino GG, Weimbs T. Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. J. Am. Soc. Nephrol. 2010 Mar; 21:489-97. [Full Text/Abstract]
    Distefano G, Boca M, Rowe I, Wodarczyk C, Ma L, Piontek KB, Germino GG, Pandolfi PP, Boletta A. Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol. Cell. Biol. 2009 May; 29:2359-71. [Full Text/Abstract]
    Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG. A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat. Med. 2007 Dec; 13:1490-5. [Full Text/Abstract]
    Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum. Mol. Genet. 2007 Aug 15; 16:1940-50. [Full Text/Abstract]
    Kaimori JY, Nagasawa Y, Menezes LF, Garcia-Gonzalez MA, Deng J, Imai E, Onuchic LF, Guay-Woodford LM, Germino GG. Polyductin undergoes notch-like processing and regulated release from primary cilia. Hum. Mol. Genet. 2007 Apr 15; 16:942-56. [Full Text/Abstract]
    Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc. Natl. Acad. Sci. U.S.A. 2006 Apr 4; 103:5466-71. [Full Text/Abstract]
    Germino GG. Linking cilia to Wnts. Nat. Genet. 2005 May; 37:455-7. [Full Text/Abstract]
    Qian F, Boletta A, Bhunia AK, Xu H, Liu L, Ahrabi AK, Watnick TJ, Zhou F, Germino GG. Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc. Natl. Acad. Sci. U.S.A. 2002 Dec 24; 99:16981-6. [Full Text/Abstract]
    Onuchic LF, Furu L, Nagasawa Y, Hou X, Eggermann T, Ren Z, Bergmann C, Senderek J, Esquivel E, Zeltner R, Rudnik-Schöneborn S, Mrug M, Sweeney W, Avner ED, Zerres K, Guay-Woodford LM, Somlo S, Germino GG. PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am. J. Hum. Genet. 2002 May; 70:1305-17. [Full Text/Abstract]
    Menezes LF, Germino GG. Polycystic kidney disease, cilia, and planar polarity. Methods Cell Biol. 2009; 94:273-97. [Full Text/Abstract]
    Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG. Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier. PLoS Genet. 2012; 8:e1003053. [Full Text/Abstract]