U.S. Department of Health and Human Services
Gregory Germino
 

 Contact Info

 
Tel: 301-496-5877
Email: germinogg@mail.nih.gov
 

 Select Experience

 
  • Senior InvestigatorKidney Diseases Branch, NIDDK, NIH2009–Present
  • Adjunct Professor of MedicineJohns Hopkins University School of Medicine2009–Present
  • Professor of Medicine Division of Nephrology, Johns Hopkins University School of Medicine2003–2009
  • Affiliate MemberMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine2002–2009
  • Joint AppointmentDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine2001–2009
  • Associate Professor of MedicineDivision of Nephrology, Johns Hopkins University School of Medicine1997–2003
  • Assistant Professor of MedicineDivision of Nephrology, Johns Hopkins University School of Medicine1992–1997
  • Associate Research ScientistInstructor and Assistant Professor, Yale University School of Medicine1988–1992
  • Research Post-Doctoral FellowNuffield Department of Medicine, Oxford University1987–1988
  • Clinical Post-Doctoral FellowNephrology, Yale University School of Medicine1986–1987
  • Internal Medicine ResidencyYale–New Haven Hospital1983–1986
  • M.D.AOA, University of Chicago Pritzker School of Medicine1983
  • B.S.Loyola University of Chicago1979
 

 Related Links

 

    Gregory G. Germino, M.D.

    Deputy Director, Office of the Director​
    Senior Investigator, Kidney Diseases Branch, Polycystic Kidney Diseases Laboratory

    Specialties: Molecular Biology/Biochemistry, Genetics/Genomics, Nephrology​​

    Gregory G. Germino, M.D.

    Senior Investigator, Kidney Diseases BranchPolycystic Kidney Disease Laboratory
    Deputy Director, Office of the Director
    Deputy Director, Office of the Deputy Director
    Specialties
    • Genetics/Genomics
    • Molecular Biology/Biochemistry
    • Nephrology

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Boddu R, Yang C, O'Connor AK, Hendrickson RC, Boone B, Cui X, Garcia-Gonzalez M, Igarashi P, Onuchic LF, Germino GG, Guay-Woodford LM. Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1. . [Full Text/Abstract]
    Ferraz RR, Fonseca JM, Germino GG, Onuchic LF, Heilberg IP. Determination of urinary lithogenic parameters in murine models orthologous to autosomal dominant polycystic kidney disease. . [Full Text/Abstract]
    Outeda P, Huso DL, Fisher SA, Halushka MK, Kim H, Qian F, Germino GG, Watnick T. Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development. . [Full Text/Abstract]
    Rowe I, Chiaravalli M, Piontek KB, Germino GG, Boletta A. Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures. Biochem Biophys Res Commun. ; 444:473-9. [Full Text/Abstract]
    Liu D, Wang CJ, Judge DP, Halushka MK, Ni J, Habashi JP, Moslehi J, Bedja D, Gabrielson KL, Xu H, Qian F, Huso D, Dietz HC, Germino GG, Watnick T. A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease. J Am Soc Nephrol. ; 25:81-91. [Full Text/Abstract]
    Menezes LF, Germino GG. Murine Models of Polycystic Kidney Disease. Drug Discov Today Dis Mech. ; 10:e153-e158. [Full Text/Abstract]
    Watnick TJ, Germino GG. Polycystic kidney disease: Polycystin-1 and polycystin-2--it's complicated. Nat Rev Nephrol. 2013 May; 9:249-50. [Full Text/Abstract]
    Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek KB, Germino GG, Zhou MI, Cohen HT. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet. 2012 Dec 15; 21:5456-71. [Full Text/Abstract]
    Wachi T, Yoshida N, Funae Y, Ueno M, Germino GG, Hirotsune S, Deguchi N. Progesterone induced mesenchymal differentiation and rescued cystic dilation of renal tubules of Pkd1(-/-) mice. Biochem Biophys Res Commun. 2012 Aug 24; 425:212-8. [Full Text/Abstract]
    Pei Y, Lan Z, Wang K, Garcia-Gonzalez M, He N, Dicks E, Parfrey P, Germino G, Watnick T. A missense mutation in PKD1 attenuates the severity of renal disease. Kidney Int. 2012 Feb; 81:412-7. [Full Text/Abstract]
    Menezes LF, Zhou F, Patterson AD, Piontek KB, Krausz KW, Gonzalez FJ, Germino GG. Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier. PLoS Genet. 2012; 8:e1003053. [Full Text/Abstract]
    Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Géléoc GS, Holt JR, Zuo J. Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. J Neurosci. 2011 Aug 24; 31:12241-50. [Full Text/Abstract]
    Miller MM, Iglesias DM, Zhang Z, Corsini R, Chu L, Murawski I, Gupta I, Somlo S, Germino GG, Goodyer PR. T-cell factor/β-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease. Kidney Int. 2011 Jul; 80:146-53. [Full Text/Abstract]
    Ferreira FM, Oliveira LC, Germino GG, Onuchic JN, Onuchic LF. Macromolecular assembly of polycystin-2 intracytosolic C-terminal domain. Proc Natl Acad Sci U S A. 2011 Jun 14; 108:9833-8. [Full Text/Abstract]
    Paul BM, Vassmer D, Taylor A, Magenheimer L, Carlton CG, Piontek KB, Germino GG, Vanden Heuvel GB. Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts. Dev Dyn. 2011 Jun; 240:1493-501. [Full Text/Abstract]
    Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T. Pkd1 and Pkd2 are required for normal placental development. PLoS One. 2010 Sep 16; 5. [Full Text/Abstract]
    Watnick T, Germino GG. mTOR inhibitors in polycystic kidney disease. N Engl J Med. 2010 Aug 26; 363:879-81. [Full Text/Abstract]
    Gallagher AR, Germino GG, Somlo S. Molecular advances in autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis. 2010 Mar; 17:118-30. [Full Text/Abstract]
    Shillingford JM, Piontek KB, Germino GG, Weimbs T. Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. J Am Soc Nephrol. 2010 Mar; 21:489-97. [Full Text/Abstract]
    Bastos AP, Piontek K, Silva AM, Martini D, Menezes LF, Fonseca JM, Fonseca II, Germino GG, Onuchic LF. Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia/reperfusion. J Am Soc Nephrol. 2009 Nov; 20:2389-402. [Full Text/Abstract]
    Distefano G, Boca M, Rowe I, Wodarczyk C, Ma L, Piontek KB, Germino GG, Pandolfi PP, Boletta A. Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol Cell Biol. 2009 May; 29:2359-71. [Full Text/Abstract]
    Raphael KL, Strait KA, Stricklett PK, Miller RL, Nelson RD, Piontek KB, Germino GG, Kohan DE. Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells. Kidney Int. 2009 Mar; 75:626-33. [Full Text/Abstract]
    Menezes LF, Germino GG. Polycystic kidney disease, cilia, and planar polarity. Methods Cell Biol. 2009; 94:273-97. [Full Text/Abstract]
    Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG. A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med. 2007 Dec; 13:1490-5. [Full Text/Abstract]
    Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG. Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet. 2007 Aug 15; 16:1940-50. [Full Text/Abstract]
    Kaimori JY, Nagasawa Y, Menezes LF, Garcia-Gonzalez MA, Deng J, Imai E, Onuchic LF, Guay-Woodford LM, Germino GG. Polyductin undergoes notch-like processing and regulated release from primary cilia. Hum Mol Genet. 2007 Apr 15; 16:942-56. [Full Text/Abstract]
    Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A. 2006 Apr 4; 103:5466-71. [Full Text/Abstract]
    Germino GG. Linking cilia to Wnts. Nat Genet. 2005 May; 37:455-7. [Full Text/Abstract]
    Qian F, Boletta A, Bhunia AK, Xu H, Liu L, Ahrabi AK, Watnick TJ, Zhou F, Germino GG. Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc Natl Acad Sci U S A. 2002 Dec 24; 99:16981-6. [Full Text/Abstract]
    Onuchic LF, Furu L, Nagasawa Y, Hou X, Eggermann T, Ren Z, Bergmann C, Senderek J, Esquivel E, Zeltner R, Rudnik-Schöneborn S, Mrug M, Sweeney W, Avner ED, Zerres K, Guay-Woodford LM, Somlo S, Germino GG. PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am J Hum Genet. 2002 May; 70:1305-17. [Full Text/Abstract]