The ultimate goal is to develop better approaches to diagnose, treat and eventually cure many congential or acquired disorders of the bone marrow.
Dr. Griffin Rodgers was named Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) on April 1, 2007. His research interests include:
- Genetic diseases: sickle cell anemia, thalassemia, red cell enzymopathies; clinical evaluation of disease severity; treatment, including pharmacological alteration of gene expression and stem cell transplantation
- Molecular genetics of human hemoglobins; gene expression and differentiation in erythroid cells in normal and perturbed hematopoietic states; pharmacological alteration of gene expression; molecular genetics of myleodysplastic and myleoproliferative syndromes
- Hematopoiesis; role of inducible and stochastic factors; hematopoietic stem cell plasticity; identification of early markers of lineage-specific differentiation
- The development of novel gene therapy strategies and their targeted application in cord blood hematopoietic stem cells
As a research investigator, Dr. Rodgers is widely recognized for his contributions to the development of the first effective—and now FDA approved—therapy for sickle cell anemia. He was a principal investigator in clinical trials to develop therapy for patients with sickle cell disease and also performed basic research that focused on understanding the molecular basis of how certain drugs induce gamma-globin gene expression. Recently, he and his collaborators have reported on a modified blood stem-cell transplant regimen that is highly effective in reversing sickle cell disease in adults and is associated with relatively low toxicity.
As Chief of the Molecular and Clinical Hematology Branch at the NIDDK, Dr. Rodgers is responsible for planning and conducting basic and clinical research on selected inherited and acquired diseases of human blood; utilizing contemporary biochemical, molecular, and physiological techniques; developing and validating models, including cellular and transgenic systems, to permit the delineation of regulatory mechanisms in normal and pathological hematopoesis, and to facilitate pharmacological or molecular genetic approaches to correct or compensate for abnormalities associated with disease states; and expediting the translation of novel basic scientific discovery to the appropriate level of preclinical or clinical investigation.
As Chief of the Molecular and Hematology Branch, Dr. Rodgers is responsible for planning and conducting research on the molecular and cellular bases of selected congenital and acquired hematological disorders; developing quantitative methods to express disease severity or activity, amenable to sequential applications; studying gene expression and differentiation in erythroid cells in normal and pathological hematopoietic states; studying the molecular basis of lineage-specific differentiation of hematopoietic stem cells; and developing therapies for hemoglobinopathies and other genetic blood disorders based on the modification of target gene expression.
Applying our Research
An increased understanding of the molecular mechanisms controlling these events would increase our ability to combat selective cytopenias, and could facilitate hematopoietic reconstitution following radiation, chemotherapy, and marrow or PSC transplantation. Also, leukemias and lymphomas are usually regarded as hematopoietic cells frozen at various stages of differentiation. Additional insights into the basic mechanism of the differentiation process are important to our understanding of leukemias and lymphomas.