U.S. Department of Health and Human Services
Harold Smith

 Contact Info

Tel: 301-594-6554
Email: harold_smith@nih.gov

 Select Experience

  • Ph.D.Columbia University1995
  • M.Phil.Columbia University1994
  • M.A.Columbia University1990

 Related Links


Harold Smith, Ph.D.

Head, Genomics Core
  • Genetics/Genomics


A selection of recent and significant publications can be viewed below.

Jaramillo-Lambert A, Fuchsman AS, Fabritius AS, Smith HE, Golden A. Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing. G3 (Bethesda). 2015 Mar 4; 5 (5; 2015 Mar 4):1007-19. [Full Text/Abstract]
Clough E, Jimenez E, Kim YA, Whitworth C, Neville MC, Hempel LU, Pavlou HJ, Chen ZX, Sturgill D, Dale RK, Smith HE, Przytycka TM, Goodwin SF, Van Doren M, Oliver B. Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes. Dev Cell. 2014 Dec 22; 31 (2014 Dec 22; 6; 31):761-73. [Full Text/Abstract]
Paix A, Wang Y, Smith HE, Lee CY, Calidas D, Lu T, Smith J, Schmidt H, Krause MW, Seydoux G. Scalable and Versatile Genome Editing Using Linear DNAs with Micro-Homology to Cas9 Sites in Caenorhabditis elegans. Genetics. 2014 Sep 23; 198 (2014 Sep 23; 4; 198):1347-56. [Full Text/Abstract]
Chen ZX, Sturgill D, Qu J, Jiang H, Park S, Boley N, Suzuki AM, Fletcher AR, Plachetzki DC, FitzGerald PC, Artieri CG, Atallah J, Barmina O, Brown JB, Blankenburg KP, Clough E, Dasgupta A, Gubbala S, Han Y, Jayaseelan JC, Kalra D, Kim YA, Kovar CL, Lee SL, Li M, Malley JD, Malone JH, Mathew T, Mattiuzzo NR, Munidasa M, Muzny DM, Ongeri F, Perales L, Przytycka TM, Pu LL, Robinson G, Thornton RL, Saada N, Scherer SE, Smith HE, Vinson C, Warner CB, Worley KC, Wu YQ, Zou X, Cherbas P, Kellis M, Eisen MB, Piano F, Kionte K, Fitch DH, Sternberg PW, Cutter AD, Duff MO, Hoskins RA, Graveley BR, Gibbs RA, Bickel PJ, Kopp A, Carninci P, Celniker SE, Oliver B, Richards S. Comparative validation of the D. melanogaster modENCODE transcriptome annotation. Genome Res. 2014 Jul; 24 (7; 2014 Jul; 24):1209-23. [Full Text/Abstract]
Smith HE. Nematode sperm motility. WormBook. 2014 Apr 4; (2014 Apr 4):1-15. [Full Text/Abstract]
Wang Y, Wang JT, Rasoloson D, Stitzel ML, O' Connell KF, Smith HE, Seydoux G. Identification of suppressors of mbk-2/DYRK by whole-genome sequencing. G3 (Bethesda). 2014 Feb 19; 4 (2014 Feb 19; 2; 4):231-41. [Full Text/Abstract]
Sturgill D, Malone JH, Sun X, Smith HE, Rabinow L, Samson ML, Oliver B. Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki). BMC Bioinformatics. 2013 Nov 9; 14 (2013 Nov 9; 14):320. [Full Text/Abstract]
Gao S, Sandstrom DJ, Smith HE, High B, Marsh JW, Nash HA. Drosophila ryanodine receptors mediate general anesthesia by halothane. Anesthesiology. 2013 Mar; 118 (118; 2013 Mar; 3):587-601. [Full Text/Abstract]
Thomas CG, Li R, Smith HE, Woodruff GC, Oliver B, Haag ES. Simplification and desexualization of gene expression in self-fertile nematodes. Curr Biol. 2012 Nov 20; 22 (2012 Nov 20; 22):2167-72. [Full Text/Abstract]
Zhu BM, Kang K, Yu JH, Chen W, Smith HE, Lee D, Sun HW, Wei L, Hennighausen L. Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes. Nucleic Acids Res. 2012 May; 40 (40; 2012 May; 10):4461-72. [Full Text/Abstract]
Malone JH, Cho DY, Mattiuzzo NR, Artieri CG, Jiang L, Dale RK, Smith HE, McDaniel J, Munro S, Salit M, Andrews J, Przytycka TM, Oliver B. Mediation of Drosophila autosomal dosage effects and compensation by network interactions. Genome Biol. 2012 Apr 24; 13 (2012 Apr 24; 4; 13):r28. [Full Text/Abstract]
Kulkarni M, Shakes DC, Guevel K, Smith HE. SPE-44 implements sperm cell fate. PLoS Genet. 2012; 8 (2012; 8; 4):e1002678. [Full Text/Abstract]
Smith HE. Identifying insertion mutations by whole-genome sequencing. Biotechniques. 2011 Feb; 50 (2; 2011 Feb; 50):96-7. [Full Text/Abstract]
Pavelec DM, Lachowiec J, Duchaine TF, Smith HE, Kennedy S. Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans. Genetics. 2009 Dec; 183 (183; 4; 2009 Dec):1283-95. [Full Text/Abstract]
del Castillo-Olivares A, Kulkarni M, Smith HE. Regulation of sperm gene expression by the GATA factor ELT-1. Dev Biol. 2009 Sep 15; 333 (2009 Sep 15; 2; 333):397-408. [Full Text/Abstract]
Kulkarni M, Smith HE. E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development. PLoS Genet. 2008 Jul 18; 4 (7; 4; 2008 Jul 18):e1000131. [Full Text/Abstract]
Smith HE. The transcriptional response of Escherichia coli to recombinant protein insolubility. J Struct Funct Genomics. 2007 Mar; 8 (8; 1; 2007 Mar):27-35. [Full Text/Abstract]