U.S. Department of Health and Human Services
Harris Bernstein

 Contact Info

Tel: 301-402-4770
Email: harris_bernstein@nih.gov

 Select Experience

  • Ph.D.Massachusetts Institute of Technology1987
  • B.A.Harvard University1980

 Related Links


    Harris D. Bernstein, Ph.D.

    Chief, Genetics and Biochemistry BranchProtein Biogenesis Section
    • Microbiology/Infectious diseases (non-viral)
    • Molecular Biology/Biochemistry


    A selection of recent and significant publications can be viewed below.

    Prasad AR, Prasad S, Nguyen H, Facista A, Lewis C, Zaitlin B, Bernstein H, Bernstein C. Novel diet-related mouse model of colon cancer parallels human colon cancer. World J Gastrointest Oncol. 2014 Jul 15; 6 (7):225-43. [Full Text/Abstract]
    Pavlova O, Peterson JH, Ieva R, Bernstein HD. Mechanistic link between β barrel assembly and the initiation of autotransporter secretion. Proc Natl Acad Sci U S A. 2013 Mar 5; 110 (10):E938-47. [Full Text/Abstract]
    Bernstein HD. Cell biology: All clear for ribosome landing. Nature. 2012 Dec 13; 492 (7428):189-91. [Full Text/Abstract]
    Ieva R, Tian P, Peterson JH, Bernstein HD. Sequential and spatially restricted interactions of assembly factors with an autotransporter beta domain. Proc Natl Acad Sci U S A. 2011 Aug 2; 108 (31):E383-91. [Full Text/Abstract]
    Peterson JH, Tian P, Ieva R, Dautin N, Bernstein HD. Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment. Proc Natl Acad Sci U S A. 2010 Oct 12; 107 (41):17739-44. [Full Text/Abstract]
    Peterson JH, Woolhead CA, Bernstein HD. The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding. Mol Microbiol. 2010 Oct; 78 (1):203-17. [Full Text/Abstract]
    Ieva R, Bernstein HD. Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane. Proc Natl Acad Sci U S A. 2009 Nov 10; 106 (45):19120-5. [Full Text/Abstract]
    Yap MN, Bernstein HD. The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel. Mol Cell. 2009 Apr 24; 34 (2):201-11. [Full Text/Abstract]
    Ieva R, Skillman KM, Bernstein HD. Incorporation of a polypeptide segment into the beta-domain pore during the assembly of a bacterial autotransporter. Mol Microbiol. 2008 Jan; 67 (1):188-201. [Full Text/Abstract]
    Barnard TJ, Dautin N, Lukacik P, Bernstein HD, Buchanan SK. Autotransporter structure reveals intra-barrel cleavage followed by conformational changes. Nat Struct Mol Biol. 2007 Dec; 14 (12):1214-20. [Full Text/Abstract]
    Dautin N, Barnard TJ, Anderson DE, Bernstein HD. Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism. EMBO J. 2007 Apr 4; 26 (7):1942-52. [Full Text/Abstract]
    Dautin N, Bernstein HD. Protein secretion in gram-negative bacteria via the autotransporter pathway. Annu Rev Microbiol. 2007; 61 :89-112. [Full Text/Abstract]
    Hegde RS, Bernstein HD. The surprising complexity of signal sequences. Trends Biochem Sci. 2006 Oct; 31 (10):563-71. [Full Text/Abstract]
    Woolhead CA, Johnson AE, Bernstein HD. Translation arrest requires two-way communication between a nascent polypeptide and the ribosome. Mol Cell. 2006 Jun 9; 22 (5):587-98. [Full Text/Abstract]
    Skillman KM, Barnard TJ, Peterson JH, Ghirlando R, Bernstein HD. Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter. Mol Microbiol. 2005 Nov; 58 (4):945-58. [Full Text/Abstract]
    Szabady RL, Peterson JH, Skillman KM, Bernstein HD. An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporter. Proc Natl Acad Sci U S A. 2005 Jan 4; 102 (1):221-6. [Full Text/Abstract]