U.S. Department of Health and Human Services
Harris Bernstein
 

 Contact Info

 
Tel: 301-402-4770
Email: harris_bernstein@nih.gov
 

 Select Experience

 
  • Ph.D.Massachusetts Institute of Technology1987
  • B.A.Harvard University1980
 

 Related Links

 

    Harris D. Bernstein, Ph.D.

    Senior Investigator, Genetics and Biochemistry BranchProtein Biogenesis Section
    Specialties
    • Microbiology/Infectious diseases (non-viral)
    • Molecular Biology/Biochemistry

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Pavlova O, Peterson JH, Ieva R, Bernstein HD. Mechanistic link between β barrel assembly and the initiation of autotransporter secretion. Proc Natl Acad Sci U S A. 2013 Mar 5; 110:E938-47. [Full Text/Abstract]
    Bernstein HD. Cell biology: All clear for ribosome landing. Nature. 2012 Dec 13; 492:189-91. [Full Text/Abstract]
    Ieva R, Tian P, Peterson JH, Bernstein HD. Sequential and spatially restricted interactions of assembly factors with an autotransporter beta domain. Proc Natl Acad Sci U S A. 2011 Aug 2; 108:E383-91. [Full Text/Abstract]
    Peterson JH, Tian P, Ieva R, Dautin N, Bernstein HD. Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment. Proc Natl Acad Sci U S A. 2010 Oct 12; 107:17739-44. [Full Text/Abstract]
    Peterson JH, Woolhead CA, Bernstein HD. The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding. Mol Microbiol. 2010 Oct; 78:203-17. [Full Text/Abstract]
    Ieva R, Bernstein HD. Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane. Proc Natl Acad Sci U S A. 2009 Nov 10; 106:19120-5. [Full Text/Abstract]
    Yap MN, Bernstein HD. The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel. Mol Cell. 2009 Apr 24; 34:201-11. [Full Text/Abstract]
    Ieva R, Skillman KM, Bernstein HD. Incorporation of a polypeptide segment into the beta-domain pore during the assembly of a bacterial autotransporter. Mol Microbiol. 2008 Jan; 67:188-201. [Full Text/Abstract]
    Barnard TJ, Dautin N, Lukacik P, Bernstein HD, Buchanan SK. Autotransporter structure reveals intra-barrel cleavage followed by conformational changes. Nat Struct Mol Biol. 2007 Dec; 14:1214-20. [Full Text/Abstract]
    Dautin N, Barnard TJ, Anderson DE, Bernstein HD. Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism. EMBO J. 2007 Apr 4; 26:1942-52. [Full Text/Abstract]
    Hegde RS, Bernstein HD. The surprising complexity of signal sequences. Trends Biochem Sci. 2006 Oct; 31:563-71. [Full Text/Abstract]
    Woolhead CA, Johnson AE, Bernstein HD. Translation arrest requires two-way communication between a nascent polypeptide and the ribosome. Mol Cell. 2006 Jun 9; 22:587-98. [Full Text/Abstract]
    Skillman KM, Barnard TJ, Peterson JH, Ghirlando R, Bernstein HD. Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter. Mol Microbiol. 2005 Nov; 58:945-58. [Full Text/Abstract]
    Szabady RL, Peterson JH, Skillman KM, Bernstein HD. An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporter. Proc Natl Acad Sci U S A. 2005 Jan 4; 102:221-6. [Full Text/Abstract]
    Dautin N, Bernstein HD. Protein secretion in gram-negative bacteria via the autotransporter pathway. Annu Rev Microbiol. 2007; 61:89-112. [Full Text/Abstract]