U.S. Department of Health and Human Services
James Balow

 Contact Info

Tel: +1 301 496 4181
Email: jimb@mail.nih.gov

 Training and Experience

M.D., University of Minnesota, 1968

B.S., College of St. Thomas, 1964

Clinical Immunology Fellowship, NIAID, NIH, 1972–1975

Internal Medicine and Nephrology Fellowships, Georgetown University, 1969–1972

 Related Links


    James E. Balow, M.D.

    Clinical Director, Division of Intramural Research
    Director of Translational Research, Division of Intramural Research​
    Senior Investigator, Kidney Disease Branch, Kidney Disease Section

    Specialties: Clinical Research​​

    James E. Balow, M.D.

    Senior Investigator, Kidney Diseases BranchKidney Diseases Section
    Clinical Director, Division of Intramural Research
    Director of Translational Research, Division of Intramural Research
    Clinical Director, Office of Clinical Director
    Specialties: Clinical Research

    Research Summary

    Current Research

    The focus of our research is the natural history, pathogenesis, and treatment of immunologically mediated glomerular diseases, particularly lupus nephritis and membranous nephropathy. Previous findings from our research section have demonstrated that intermittent pulse cyclophosphamide therapy has the highest therapeutic index among currently available immunosuppressive drug therapies in the treatment of proliferative forms of lupus nephritis.

    In light of the intrinsic risk of gonadal toxicity of pulse cyclophosphamide therapy, we are conducting studies designed to examine the efficacy and toxicity profile of alternative immunomodulating agents, particularly combinations of rituximab, calcineurin inhibitors, and antimetabolite drugs.

    We are currently conducting pilot studies in membranous nephropathy to evaluate the safety and efficacy of combined rituximab and cyclosporine.