U.S. Department of Health and Human Services
James Balow
 

 Contact Info

 
Tel: 301-496-4181
Email: jimb@mail.nih.gov
 

 Select Experience

 
  • Clinical Immunology FellowshipNIAID, NIH1972–1975
  • Internal Medicine and Nephrology FellowshipsGeorgetown University1969–1972
  • M.D.University of Minnesota1968
  • B.S.College of St. Thomas1964
 

 Related Links

 

    James E. Balow, M.D.

    Clinical Director, Division of Intramural Research
    Director of Translational Research, Division of Intramural Research​
    Senior Investigator, Kidney Disease Branch, Kidney Disease Section

    Specialties: Clinical Research​​

    James Balow

    Senior Investigator, Kidney Diseases BranchKidney Diseases Section
    Clinical Director, Division of Intramural Research
    Director of Translational Research, Division of Intramural Research
    Clinical Director, Office of Clinical Director
    Specialties
    • Clinical Research

    Research Summary

    Current Research

    The focus of our research is the natural history, pathogenesis, and treatment of immunologically mediated glomerular diseases, particularly lupus nephritis and membranous nephropathy. Previous findings from our research section have demonstrated that intermittent pulse cyclophosphamide therapy has the highest therapeutic index among currently available immunosuppressive drug therapies in the treatment of proliferative forms of lupus nephritis.

    In light of the intrinsic risk of gonadal toxicity of pulse cyclophosphamide therapy, we are conducting studies designed to examine the efficacy and toxicity profile of alternative immunomodulating agents, particularly combinations of rituximab, calcineurin inhibitors, and antimetabolite drugs.

    We are currently conducting pilot studies in membranous nephropathy to evaluate the safety and efficacy of combined rituximab and cyclosporine.