U.S. Department of Health and Human Services
Jeffrey Kopp

 Contact Info

Tel: 301-594-3403
Email: jeffreyk@mail.nih.gov

 Select Experience

  • Consulting NephrologistMark Hatfield Clinical Research Center, NIHPresent
  • Commissioned Officer (Captain) Active Member (Rapid Deployment Force Teams PHS 1)U.S. Public Health ServicePresent
  • Adjunct Professor of MedicineUniformed Services University of the Health SciencesPresent
  • Senior InvestigatorNIDDK, NIH1995-present
  • Medical Staff FellowNIH1987-1995
  • Complete Training in Internal Medicine and NephrologyUniversity of Washington1987
  • M.D.University of Pennsylvania Medical School1980
  • B.A.Harvard College1975

 Related Links

  • Clinical Research
  • Genetics/Genomics
  • Health Disparities


A selection of recent and significant publications can be viewed below.

Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP. Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. J Am Soc Nephrol. 2014 Mar 27; 25 (25; 2014 Mar 27; 9):1991-2002. [Full Text/Abstract]
Wang W, Qiu L, Howard A, Solis N, Li C, Wang X, Kopp JB, Levi M. Protective effects of aliskiren and valsartan in mice with diabetic nephropathy. J Renin Angiotensin Aldosterone Syst. 2014 Jul 16; (2014 Jul 16). [Full Text/Abstract]
Fornoni A, Merscher S, Kopp JB. Lipid biology of the podocyte--new perspectives offer new opportunities. Nat Rev Nephrol. 2014 Jul; 10 (7; 10; 2014 Jul):379-88. [Full Text/Abstract]
Starke C, Betz H, Hickmann L, Lachmann P, Neubauer B, Kopp JB, Sequeira-Lopez ML, Gomez RA, Hohenstein B, Todorov VT, Hugo CP. Renin Lineage Cells Repopulate the Glomerular Mesangium after Injury. J Am Soc Nephrol. 2014 Jun 5; (2014 Jun 5). [Full Text/Abstract]
Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J. Evolution of the primate trypanolytic factor APOL1. Proc Natl Acad Sci U S A. 2014 May 20; 111 (20; 2014 May 20; 111):E2130-9. [Full Text/Abstract]
Kansy K, Mueller AA, Mücke T, Kopp JB, Koersgen F, Wolff KD, Zeilhofer HF, Hölzle F, Pradel W, Schneider M, Kolk A, Smeets R, Acero J, Hoffmann J, DÖSAK Collaborative Group for Microsurgical Reconstruction. Microsurgical reconstruction of the head and neck - Current concepts of maxillofacial surgery in Europe. J Craniomaxillofac Surg. 2014 May 11; (2014 May 11). [Full Text/Abstract]
Dobrinskikh E, Okamura K, Kopp JB, Doctor RB, Blaine J. Human podocytes perform polarized, caveolae-dependent albumin endocytosis. Am J Physiol Renal Physiol. 2014 May 1; 306 (2014 May 1; 9; 306):F941-51. [Full Text/Abstract]
Lee H, Abe Y, Lee I, Shrivastav S, Crusan AP, Hüttemann M, Hopfer U, Felder RA, Asico LD, Armando I, Jose PA, Kopp JB. Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats. Kidney Int. 2014 Mar; 85 (85; 2014 Mar; 3):561-9. [Full Text/Abstract]
Carson JM, Okamura K, Wakashin H, McFann K, Dobrinskikh E, Kopp JB, Blaine J. Podocytes Degrade Endocytosed Albumin Primarily in Lysosomes. PLoS One. 2014; 9 (6; 2014; 9):e99771. [Full Text/Abstract]
Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT Jr, Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ, AASK Study Investigators, CRIC Study Investigators. APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med. 2013 Dec 5; 369 (23; 2013 Dec 5; 369):2183-96. [Full Text/Abstract]
Kopp JB. JC viruria and kidney disease in APOL1 risk genotype individuals: is this a clue to a gene × environment interaction?. Kidney Int. 2013 Dec; 84 (6; 2013 Dec; 84):1069-72. [Full Text/Abstract]
Huynh N, Blain D, Glaser T, Doss EL, Zein WM, Lang DM, Baker EH, Hill S, Brewer CC, Kopp JB, Bardakjian TM, Maumenee IH, Bateman BJ, Brooks BP. Systemic diagnostic testing in patients with apparently isolated uveal coloboma. Am J Ophthalmol. 2013 Dec; 156 (156; 6; 2013 Dec):1159-1168.e4. [Full Text/Abstract]
Wang L, Teng R, Di L, Rogers H, Wu H, Kopp JB, Noguchi CT. PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes. 2013 Dec; 62 (2013 Dec; 12; 62):4122-31. [Full Text/Abstract]
Kruszka PS, Manoli I, Sloan JL, Kopp JB, Venditti CP. Renal growth in isolated methylmalonic acidemia. Genet Med. 2013 Dec; 15 (2013 Dec; 15; 12):990-6. [Full Text/Abstract]
Agarwal N, Iyer D, Patel SG, Sekhar RV, Phillips TM, Schubert U, Oplt T, Buras ED, Samson SL, Couturier J, Lewis DE, Rodriguez-Barradas MC, Jahoor F, Kino T, Kopp JB, Balasubramanyam A. HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation. Sci Transl Med. 2013 Nov 27; 5 (213; 5; 2013 Nov 27):213ra164. [Full Text/Abstract]
Abe Y, Sakairi T, Beeson C, Kopp JB. TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway. Am J Physiol Renal Physiol. 2013 Nov 15; 305 (2013 Nov 15; 10; 305):F1477-90. [Full Text/Abstract]
Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam SK, Cohen CD, Groop PH, Barshop BA, Natarajan L, Nyhan WL, Naviaux RK. Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol. 2013 Nov; 24 (24; 2013 Nov; 11):1901-12. [Full Text/Abstract]
Burghardt T, Kastner J, Suleiman H, Rivera-Milla E, Stepanova N, Lottaz C, Kubitza M, Böger CA, Schmidt S, Gorski M, de Vries U, Schmidt H, Hertting I, Kopp J, Rascle A, Moser M, Heid IM, Warth R, Spang R, Wegener J, Mierke CT, Englert C, Witzgall R. LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys. J Am Soc Nephrol. 2013 Nov; 24 (24; 2013 Nov; 11):1830-48. [Full Text/Abstract]
Gasser DL, Winkler CA, Peng M, An P, McKenzie LA, Kirk GD, Shi Y, Xie LX, Marbois BN, Clarke CF, Kopp JB. Focal Segmental Glomerulosclerosis Is Associated With a PDSS2 Haplotype and Independently, With a Decreased Content of Coenzyme Q10. Am J Physiol Renal Physiol. 2013 Oct 15; 305 (8; 2013 Oct 15; 305):F1228-38. [Full Text/Abstract]
Shrivastav S, Zhang L, Okamoto K, Lee H, Lagranha C, Abe Y, Balasubramanyam A, Lopaschuk GD, Kino T, Kopp JB. HIV-1 Vpr enhances PPARβ/δ-mediated transcription, increases PDK4 expression and reduces PDC activity. Mol Endocrinol. 2013 Sep; 27 (2013 Sep; 27; 9):1564-76. [Full Text/Abstract]
Zhou H, Kajiyama H, Tsuji T, Hu X, Leelahavanichkul A, Vento S, Frank R, Kopp JB, Trachtman H, Star RA, Yuen PS. Urinary exosomal Wilms tumor-1 as a potential biomarker for podocyte injury. Am J Physiol Renal Physiol. 2013 Aug 15; 305 (4; 2013 Aug 15; 305):F553-9. [Full Text/Abstract]
Barisoni L, Nast CC, Jennette JC, Hodgin JB, Herzenberg AM, Lemley KV, Conway CM, Kopp JB, Kretzler M, Lienczewski C, Avila-Casado C, Bagnasco S, Sethi S, Tomaszewski J, Gasim AH, Hewitt SM. Digital Pathology Evaluation in the Multicenter Nephrotic Syndrome Study Network (NEPTUNE). Clin J Am Soc Nephrol. 2013 Aug; 8 (8; 2013 Aug):1449-59. [Full Text/Abstract]
Kopp JB. An Expanding Universe of FSGS Genes and Phenotypes: LMX1B Mutations Cause Familial Autosomal Dominant FSGS Lacking Extrarenal Manifestations. J Am Soc Nephrol. 2013 Jul; 24 (8; 24; 2013 Jul):1183-5. [Full Text/Abstract]
Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron AC, Kopp JB, Yamamoto M, Noguchi CT. Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation. Int J Biochem Cell Biol. 2013 Jul; 45 (7; 45; 2013 Jul):1155-64. [Full Text/Abstract]
Zhou H, Hasni SA, Perez P, Tandon M, Jang SI, Zheng C, Kopp JB, Austin H 3rd, Balow JE, Alevizos I, Illei GG. miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1. J Am Soc Nephrol. 2013 Jun; 24 (7; 24; 2013 Jun):1073-87. [Full Text/Abstract]
Lempert KD, Kopp JB. Hurricane Sandy as a kidney failure disaster. Am J Kidney Dis. 2013 Jun; 61 (6; 2013 Jun; 61):865-8. [Full Text/Abstract]
Purswani M, Patel K, Kopp JB, Seage GR 3rd, Chernoff MC, Hazra R, Siberry GK, Mofenson LM, Scott GB, Van Dyke RB, for the Pediatric HIVAIDS Cohort Study. Tenofovir Treatment Duration Predicts Proteinuria in a Multiethnic United States Cohort of Children and Adolescents With Perinatal HIV-1 Infection. Pediatr Infect Dis J. 2013 May; 32 (2013 May; 32; 5):495-500. [Full Text/Abstract]
Kopp JB. Rethinking hypertensive kidney disease: arterionephrosclerosis as a genetic, metabolic, and inflammatory disorder. Curr Opin Nephrol Hypertens. 2013 May; 22 (2013 May; 3; 22):266-72. [Full Text/Abstract]
Gadegbeku CA, Gipson DS, Holzman LB, Ojo AO, Song PX, Barisoni L, Sampson MG, Kopp JB, Lemley KV, Nelson PJ, Lienczewski CC, Adler SG, Appel GB, Cattran DC, Choi MJ, Contreras G, Dell KM, Fervenza FC, Gibson KL, Greenbaum LA, Hernandez JD, Hewitt SM, Hingorani SR, Hladunewich M, Hogan MC, Hogan SL, Kaskel FJ, Lieske JC, Meyers KE, Nachman PH, Nast CC, Neu AM, Reich HN, Sedor JR, Sethna CB, Trachtman H, Tuttle KR, Zhdanova O, Zilleruelo GE, Kretzler M. Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int. 2013 Apr; 83 (83; 4; 2013 Apr):749-56. [Full Text/Abstract]
Kopp JB. Glomerular disease in 2012: more mechanistic insights, but translational progress is slow. Nat Rev Nephrol. 2013 Feb; 9 (2; 2013 Feb; 9):67-8. [Full Text/Abstract]
Chandra P, Kopp JB. Viruses and collapsing glomerulopathy: a brief critical review. Clin Kidney J. 2013 Feb; 6 (6; 2013 Feb; 1):1-5. [Full Text/Abstract]
Cravedi P, Kopp JB, Remuzzi G. Recent progress in the pathophysiology and treatment of FSGS recurrence. Am J Transplant. 2013 Feb; 13 (2; 2013 Feb; 13):266-74. [Full Text/Abstract]
Hadigan C, Edwards E, Rosenberg A, Purdy JB, Fleischman E, Howard L, Mican JM, Sampath K, Oyalowo A, Johnson A, Adler A, Rehm C, Smith M, Lai L, Kopp JB. Microalbuminuria in HIV disease. Am J Nephrol. 2013; 37 (37; 5; 2013):443-51. [Full Text/Abstract]
Lipkowitz MS, Freedman BI, Langefeld CD, Comeau ME, Bowden DW, Kao WH, Astor BC, Bottinger EP, Iyengar SK, Klotman PE, Freedman RG, Zhang W, Parekh RS, Choi MJ, Nelson GW, Winkler CA, Kopp JB, SK Investigators. Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans. Kidney Int. 2013 Jan; 83 (83; 1; 2013 Jan):114-20. [Full Text/Abstract]
Guess AJ, Ayoob R, Chanley M, Manley J, Cajaiba MM, Agrawal S, Pengal R, Pyle AL, Becknell B, Kopp JB, Ronkina N, Gaestel M, Benndorf R, Smoyer WE. Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis. PLoS One. 2013; 8 (8; 1; 2013):e54239. [Full Text/Abstract]
Okamura K, Dummer P, Kopp J, Qiu L, Levi M, Faubel S, Blaine J. Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death. PLoS One. 2013; 8 (8; 1; 2013):e54817. [Full Text/Abstract]
Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, Mokrzycki MH, Kimmel PL, Limou S, Ahuja TS, Berns JS, Fryc J, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollak M, Winkler CA. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol. 2011 Nov; 22 (2011 Nov; 22; 11):2129-37. [Full Text/Abstract]
Marasà M, Kopp JB. Monoclonal antibodies for podocytopathies: rationale and clinical responses. Nat Rev Nephrol. 2009 Jun; 5 (6; 2009 Jun; 5):337-48. [Full Text/Abstract]
Kopp JB, Smith MW, Nelson GW, Johnson RC, Freedman BI, Bowden DW, Oleksyk T, McKenzie LM, Kajiyama H, Ahuja TS, Berns JS, Briggs W, Cho ME, Dart RA, Kimmel PL, Korbet SM, Michel DM, Mokrzycki MH, Schelling JR, Simon E, Trachtman H, Vlahov D, Winkler CA. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet. 2008 Oct; 40 (40; 2008 Oct; 10):1175-84. [Full Text/Abstract]
Shrivastav S, Kino T, Cunningham T, Ichijo T, Schubert U, Heinklein P, Chrousos GP, Kopp JB. Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy. Mol Endocrinol. 2008 Feb; 22 (2; 22; 2008 Feb):234-47. [Full Text/Abstract]
Cho ME, Smith DC, Branton MH, Penzak SR, Kopp JB. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2007 Sep; 2 (2; 5; 2007 Sep):906-13. [Full Text/Abstract]