U.S. Department of Health and Human Services
Jenny Hinshaw

 Contact Info

Tel: 301-594-0842
Email: jennyh@helix.nih.gov

 Select Experience

  • Ph.D.Brown University1989
  • B.A.Wellesley College1982

 Related Links

  • Cell Biology/Cell Signaling
  • Structural Biology


A selection of recent and significant publications can be viewed below.

Erlandson KJ, Bisht H, Weisberg AS, Hyun SI, Hansen BT, Fischer ER, Hinshaw JE, Moss B. Poxviruses Encode a Reticulon-Like Protein that Promotes Membrane Curvature. Cell Rep. 2016 Feb 24; 14 (14; 9; 2016 Feb 24):2084-2091. [Full Text/Abstract]
Sambuughin N, Goldfarb LG, Sivtseva TM, Davydova TK, Vladimirtsev VA, Osakovskiy VL, Danilova AP, Nikitina RS, Ylakhova AN, Diachkovskaya MP, Sundborger AC, Renwick NM, Platonov FA, Hinshaw JE, Toro C. Adult-onset autosomal dominant spastic paraplegia linked to a GTPase-effector domain mutation of dynamin 2. BMC Neurol. 2015 Oct 30; 15 (15; 2015 Oct 30):223. [Full Text/Abstract]
Mattila JP, Shnyrova AV, Sundborger AC, Hortelano ER, Fuhrmans M, Neumann S, Müller M, Hinshaw JE, Schmid SL, Frolov VA. A hemi-fission intermediate links two mechanistically distinct stages of membrane fission. Nature. 2015 Jun 29; 524 (2015 Jun 29; 524; 7563):109-13. [Full Text/Abstract]
Sundborger AC, Fang S, Heymann JA, Ray P, Chappie JS, Hinshaw JE. A dynamin mutant defines a superconstricted prefission state. Cell Rep. 2014 Aug 7; 8 (8; 2014 Aug 7; 3):734-42. [Full Text/Abstract]
Sundborger AC, Hinshaw JE. Regulating dynamin dynamics during endocytosis. F1000Prime Rep. 2014; 6 (6; 2014):85. [Full Text/Abstract]
Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell. 2011 Sep 30; 147 (147; 2011 Sep 30; 1):209-22. [Full Text/Abstract]
Sundborger A, Soderblom C, Vorontsova O, Evergren E, Hinshaw JE, Shupliakov O. An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling. J Cell Sci. 2011 Jan 1; 124 (124; Pt 1; 2011 Jan 1):133-43. [Full Text/Abstract]
Mears JA, Lackner LL, Fang S, Ingerman E, Nunnari J, Hinshaw JE. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat Struct Mol Biol. 2011 Jan; 18 (2011 Jan; 1; 18):20-6. [Full Text/Abstract]
Ban T, Heymann JA, Song Z, Hinshaw JE, Chan DC. OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation. Hum Mol Genet. 2010 Jun 1; 19 (2010 Jun 1; 19; 11):2113-22. [Full Text/Abstract]
Kitajiri S, Sakamoto T, Belyantseva IA, Goodyear RJ, Stepanyan R, Fujiwara I, Bird JE, Riazuddin S, Riazuddin S, Ahmed ZM, Hinshaw JE, Sellers J, Bartles JR, Hammer JA 3rd, Richardson GP, Griffith AJ, Frolenkov GI, Friedman TB. Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell. 2010 May 28; 141 (2010 May 28; 141; 5):786-98. [Full Text/Abstract]
Schulz TA, Choi MG, Raychaudhuri S, Mears JA, Ghirlando R, Hinshaw JE, Prinz WA. Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol. 2009 Dec 14; 187 (6; 2009 Dec 14; 187):889-903. [Full Text/Abstract]
Heymann JA, Hinshaw JE. Dynamins at a glance. J Cell Sci. 2009 Oct 1; 122 (2009 Oct 1; 122; Pt 19):3427-31. [Full Text/Abstract]
Bethoney KA, King MC, Hinshaw JE, Ostap EM, Lemmon MA. A possible effector role for the pleckstrin homology (PH) domain of dynamin. Proc Natl Acad Sci U S A. 2009 Aug 11; 106 (106; 32; 2009 Aug 11):13359-64. [Full Text/Abstract]
Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth MJ, Shaw JT, Hinshaw JE, Green DR, Nunnari J. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb; 14 (14; 2; 2008 Feb):193-204. [Full Text/Abstract]
Mears JA, Hinshaw JE. Visualization of dynamins. Methods Cell Biol. 2008; 88 (2008; 88):237-56. [Full Text/Abstract]
Mears JA, Ray P, Hinshaw JE. A corkscrew model for dynamin constriction. Structure. 2007 Oct; 15 (2007 Oct; 15; 10):1190-202. [Full Text/Abstract]
Naylor K, Ingerman E, Okreglak V, Marino M, Hinshaw JE, Nunnari J. Mdv1 interacts with assembled dnm1 to promote mitochondrial division. J Biol Chem. 2006 Jan 27; 281 (281; 4; 2006 Jan 27):2177-83. [Full Text/Abstract]
Nie Z, Hirsch DS, Luo R, Jian X, Stauffer S, Cremesti A, Andrade J, Lebowitz J, Marino M, Ahvazi B, Hinshaw JE, Randazzo PA. A BAR domain in the N terminus of the Arf GAP ASAP1 affects membrane structure and trafficking of epidermal growth factor receptor. Curr Biol. 2006 Jan 24; 16 (16; 2; 2006 Jan 24):130-9. [Full Text/Abstract]
Ingerman E, Perkins EM, Marino M, Mears JA, McCaffery JM, Hinshaw JE, Nunnari J. Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol. 2005 Sep 26; 170 (170; 7; 2005 Sep 26):1021-7. [Full Text/Abstract]
Kochs G, Reichelt M, Danino D, Hinshaw JE, Haller O. Assay and functional analysis of dynamin-like Mx proteins. Methods Enzymol. 2005; 404 (2005; 404):632-43. [Full Text/Abstract]