U.S. Department of Health and Human Services
John Hanover

 Contact Info

Tel: 301-496-0943
Email: jah@helix.nih.gov

 Select Experience

  • Ph.D.Johns Hopkins University School of Medicine1981
  • B.S.University of Tulsa1976

 Related Links

  • Cell Biology/Cell Signaling
  • Genetics/Genomics
  • Molecular Biology/Biochemistry


A selection of recent and significant publications can be viewed below.

Abd-Elmoniem KZ, Bakalov VK, Matta JR, Muldoon N, Hanover JA, Bondy CA, Gharib AM. X Chromosome Parental Origin and Aortic Stiffness in Turner Syndrome. Clin Endocrinol (Oxf). 2014 Sep; 81 (81; 3; 2014 Sep):467-70. [Full Text/Abstract]
Stichelen SO, Abramowitz LK, Hanover JA. X Marks the Spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?. Biochem Biophys Res Commun. 2014 Jun 21; (2014 Jun 21). [Full Text/Abstract]
Kim EJ, Abramowitz LK, Bond MR, Love DC, Ahn JS, Kang DW, Leucke HF, Kang DW, Hanover JA. Versatile O-GlcNAc Transferase Assay for High-throughput Identification of Enzyme Variants, Substrates, and Inhibitors. Bioconjug Chem. 2014 Jun 18; 25 (25; 6; 2014 Jun 18):1025-30. [Full Text/Abstract]
Harwood KR, Hanover JA. Nutrient-driven O-GlcNAc cycling - think globally but act locally. J Cell Sci. 2014 May 1; 127 (127; 2014 May 1; Pt 9):1857-67. [Full Text/Abstract]
Sarker MM, Zhou M, Rameshwar P, Hanover JA. Functions and Roles of Proteins: Diabetes as a Paradigm. Prog Biophys Mol Biol. 2014 Jan; 114 (2014 Jan; 114; 1):2-7. [Full Text/Abstract]
Ranuncolo SM, Ghosh S, Hanover JA, Hart GW, Lewis BA. Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J Biol Chem. 2012 Jul 6; 287 (28; 287; 2012 Jul 6):23549-61. [Full Text/Abstract]
Hanover JA, Krause MW, Love DC. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat Rev Mol Cell Biol. 2012 Apr 23; 13 (2012 Apr 23; 13; 5):312-21. [Full Text/Abstract]
Keembiyehetty CN, Krzeslak A, Love DC, Hanover JA. A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome. J Cell Sci. 2011 Aug 15; 124 (124; 2011 Aug 15; Pt 16):2851-60. [Full Text/Abstract]
Mondoux MA, Love DC, Ghosh SK, Fukushige T, Bond M, Weerasinghe GR, Hanover JA, Krause MW. O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans. Genetics. 2011 Jun; 188 (188; 2; 2011 Jun):369-82. [Full Text/Abstract]
Hanover JA. A versatile sugar transferase makes the cut. Cell. 2011 Feb 4; 144 (144; 3; 2011 Feb 4):321-3. [Full Text/Abstract]
Hanover JA. Epigenetics gets sweeter: O-GlcNAc joins the "histone code". Chem Biol. 2010 Dec 22; 17 (17; 12; 2010 Dec 22):1272-4. [Full Text/Abstract]
Sekine O, Love DC, Rubenstein DS, Hanover JA. Blocking O-linked GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis. J Biol Chem. 2010 Dec 3; 285 (2010 Dec 3; 49; 285):38684-91. [Full Text/Abstract]
Kim EJ, Love DC, Darout E, Abdo M, Rempel B, Withers SG, Rablen PR, Hanover JA, Knapp S. OGA inhibition by GlcNAc-selenazoline. Bioorg Med Chem. 2010 Oct 1; 18 (2010 Oct 1; 19; 18):7058-64. [Full Text/Abstract]
Love DC, Krause MW, Hanover JA. O-GlcNAc cycling: emerging roles in development and epigenetics. Semin Cell Dev Biol. 2010 Aug; 21 (6; 2010 Aug; 21):646-54. [Full Text/Abstract]
Love DC, Ghosh S, Mondoux MA, Fukushige T, Wang P, Wilson MA, Iser WB, Wolkow CA, Krause MW, Hanover JA. Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A. 2010 Apr 20; 107 (2010 Apr 20; 107; 16):7413-8. [Full Text/Abstract]
Hanover JA, Krause MW, Love DC. The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta. 2010 Feb; 1800 (2; 1800; 2010 Feb):80-95. [Full Text/Abstract]
Lazarus BD, Love DC, Hanover JA. O-GlcNAc cycling: implications for neurodegenerative disorders. Int J Biochem Cell Biol. 2009 Nov; 41 (41; 2009 Nov; 11):2134-46. [Full Text/Abstract]
Hanover JA, Love DC, Prinz WA. Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation. J Biol Chem. 2009 May 8; 284 (19; 284; 2009 May 8):12593-7. [Full Text/Abstract]
Chen S, Whetstine JR, Ghosh S, Hanover JA, Gali RR, Grosu P, Shi Y. The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. Proc Natl Acad Sci U S A. 2009 Feb 3; 106 (106; 2009 Feb 3; 5):1496-501. [Full Text/Abstract]
Krawczyk E, Suprynowicz FA, Liu X, Dai Y, Hartmann DP, Hanover J, Schlegel R. Koilocytosis: a cooperative interaction between the human papillomavirus E5 and E6 oncoproteins. Am J Pathol. 2008 Sep; 173 (173; 3; 2008 Sep):682-8. [Full Text/Abstract]
Krawczyk E, Hanover JA, Schlegel R, Suprynowicz FA. Karyopherin beta3: a new cellular target for the HPV-16 E5 oncoprotein. Biochem Biophys Res Commun. 2008 Jul 11; 371 (4; 2008 Jul 11; 371):684-8. [Full Text/Abstract]
Wesierska-Gadek J, Klima A, Ranftler C, Komina O, Hanover J, Invernizzi P, Penner E. Characterization of the antibodies to p62 nucleoporin in primary biliary cirrhosis using human recombinant antigen. J Cell Biochem. 2008 May 1; 104 (2008 May 1; 104; 1):27-37. [Full Text/Abstract]