We are studying the biological processes that lead to multiple antibiotic resistance in Escherichia coli (E. coli), a common bacterium that sometimes causes serious food poisoning in humans. Normally, treatment of an infection with an antibiotic results in a high concentration of antibiotic in the bacterium which leads to its death. Our research is focussed on mechanisms which enable the bacterium to pump the antibiotic out of the cell as quickly as it enters the cell. We want to find ways to prevent these pumps from working effectively.
affect antibiotic resistance.