U.S. Department of Health and Human Services
Judah Lee Rosner
 

 Contact Info

 
Tel: 301-496-5466
Email: jlrosner@helix.nih.gov
 

 Select Experience

 
  • Ph.D.Yale University1967
  • M.A.Yale University1964
  • B.A.Columbia College1960
 

 Related Links

 

    Judah L. Rosner, Ph.D.

    Senior Investigator, Laboratory of Molecular BiologyMolecular Genetics Section
    Specialties
    • Molecular Biology/Biochemistry

    Research Summary

    Research Goal

    We want to learn how to counter antibiotic resistance mechanisms of bacteria.

    Current Research

    Our major research interest is to understand how bacterial gene expression is regulated, particularly genes that engender multiple antibiotic resistance.  Specifically, we are studying the mechanism of transcriptional activation by MarA, SoxS, and Rob, a homologous group of proteins that stimulates the expression of more than 40 genes involved in resistance to diverse antibiotics, superoxides, and organic solvents in Escherichia coli.  By combining genetics and molecular biology, we are learning how these proteins are regulated and how they bind to DNA and interact with RNA polymerase to activate transcription.

    We are also investigating the mechanisms whereby cellular metabolites upregulate the activities of stress-response systems, which in turn activate genes for efflux pumps that rid the cells of antibiotics.​

    Applying our Research

    The goal is to understand how bacteria become antibiotic resistant so that we can create tools for overcoming the resistance.

    Need for Further Study

    Further research is needed to study the basic mechanisms of stress-response systems.