U.S. Department of Health and Human Services
Judah Lee Rosner
 

 Contact Info

 
Tel: 301-496-5466
Email: jlrosner@helix.nih.gov
 

 Select Experience

 
  • Ph.D.Yale University1967
  • M.A.Yale University1964
  • B.A.Columbia College1960
 

 Related Links

 

Judah L. Rosner, Ph.D.

Senior Investigator, Molecular Genetics SectionLaboratory of Molecular Biology
Specialties
  • Genetics/Genomics
  • Microbiology/Infectious diseases (non-viral)
  • Molecular Biology/Biochemistry
Research Summary/In Plain Language

Research Summary

Research Goal

The goal of the research is to learn how to counter antibiotic resistance mechanisms of bacteria.

Current Research

Our major research interest is to understand how bacterial gene expression is regulated, particularly genes that engender multiple antibiotic resistance.  Specifically, we are studying the mechanism of transcriptional activation by MarA, SoxS, and Rob, a homologous group of proteins that stimulates the expression of more than 40 genes involved in resistance to diverse antibiotics, superoxides, and organic solvents in Escherichia coli.  By combining genetics and molecular biology, we are learning how these proteins are regulated and how they bind to DNA and interact with RNA polymerase to activate transcription.

We are also investigating the mechanisms whereby cellular metabolites upregulate the activities of stress-response systems, which in turn activate genes for efflux pumps that rid the cells of the metabolites but also antibiotics.​

Applying our Research

By understanding the mechanisms bacteria use to become antibiotic resistant, we hope to create tools for defeating the mechanisms thereby overcoming the resistance.

Need for Further Study

The purpose of ongoing research is to understand the nature of multidrug resistance systems and to use this information to devise treatments that will prevent these systms from being effective.