U.S. Department of Health and Human Services
Jürgen Wess

 Contact Info

Tel: 301-402-3589
Email: jurgenw@helix.nih.gov

 Select Experience

  • ChiefMolecular Signaling Section, Laboratory of Biological Chemistry, NIDDK, NIH1998
  • HeadG Protein-Coupled Receptor Unit, NIDDK, NIH1993-1997
  • HeadG Protein-Coupled Receptor Unit, NINDS, NIH1991-1993
  • Postdoctoral FellowJoint Appointment at NIMH and NINDS, NIH1988-1991
  • Ph.D.Johann Wolfgang-Goethe University1987

 Related Links


    • Cell Biology/Cell Signaling
    • Molecular Biology/Biochemistry
    • Molecular Pharmacology/Toxicology


    A selection of recent and significant publications can be viewed below.

    Procino G, Milano S, Carmosino M, Barbieri C, Nicoletti MC, Li JH, Wess J, Svelto M. Combination of secretin and fluvastatin ameliorates the polyuria associated with X-linked nephrogenic diabetes insipidus in mice. Kidney Int. 2014 Jul; 86 (86; 2014 Jul; 1):127-38. [Full Text/Abstract]
    Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J. Muscarinic acetylcholine receptors: novel opportunities for drug development. Nat Rev Drug Discov. 2014 Jul; 13 (7; 13; 2014 Jul):549-60. [Full Text/Abstract]
    Byun NE, Grannan M, Bubser M, Barry RL, Thompson A, Rosanelli J, Gowrishankar R, Kelm ND, Damon S, Bridges TM, Melancon BJ, Tarr JC, Brogan JT, Avison MJ, Deutch AY, Wess J, Wood MR, Lindsley CW, Gore JC, Conn PJ, Jones CK. Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100. Neuropsychopharmacology. 2014 Jun; 39 (39; 7; 2014 Jun):1578-93. [Full Text/Abstract]
    Kruse AC, Hu J, Kobilka BK, Wess J. Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development. Curr Opin Pharmacol. 2014 Jun; 16 (16; 2014 Jun):24-30. [Full Text/Abstract]
    Nichols JL, Gladwell W, Verhein KC, Cho HY, Wess J, Suzuki O, Wiltshire T, Kleeberger SR. Genome-wide association mapping of acute lung injury in neonatal inbred mice. FASEB J. 2014 Jun; 28 (28; 6; 2014 Jun):2538-50. [Full Text/Abstract]
    Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem. 2014 May 16; 289 (20; 289; 2014 May 16):14321-30. [Full Text/Abstract]
    Gericke A, Steege A, Manicam C, Böhmer T, Wess J, Pfeiffer N. Role of the M3 muscarinic acetylcholine receptor subtype in murine ophthalmic arteries after endothelial removal. Invest Ophthalmol Vis Sci. 2014 Jan 29; 55 (2014 Jan 29; 55; 1):625-31. [Full Text/Abstract]
    Jain S, Ruiz de Azua I, Lu H, White MF, Guettier JM, Wess J. Chronic activation of a designer G(q)-coupled receptor improves β cell function. J Clin Invest. 2013 Apr 1; 123 (2013 Apr 1; 123; 4):1750-62. [Full Text/Abstract]
    Arteaga-Solis E, Zee T, Emala CW, Vinson C, Wess J, Karsenty G. Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab. 2013 Jan 8; 17 (17; 1; 2013 Jan 8):35-48. [Full Text/Abstract]
    Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK. Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature. 2012 Feb 22; 482 (2012 Feb 22; 482; 7386):552-6. [Full Text/Abstract]
    Hu J, Thor D, Zhou Y, Liu T, Wang Y, McMillin SM, Mistry R, Challiss RA, Costanzi S, Wess J. Structural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation. FASEB J. 2012 Feb; 26 (2012 Feb; 2; 26):604-16. [Full Text/Abstract]
    Ruiz de Azua I, Gautam D, Guettier JM, Wess J. Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications. Trends Endocrinol Metab. 2011 Feb; 22 (2; 2011 Feb; 22):74-80. [Full Text/Abstract]
    Hu J, Wang Y, Zhang X, Lloyd JR, Li JH, Karpiak J, Costanzi S, Wess J. Structural basis of G protein-coupled receptor-G protein interactions. Nat Chem Biol. 2010 Jul; 6 (6; 7; 2010 Jul):541-8. [Full Text/Abstract]
    Ruiz de Azua I, Scarselli M, Rosemond E, Gautam D, Jou W, Gavrilova O, Ebert PJ, Levitt P, Wess J. RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo. Proc Natl Acad Sci U S A. 2010 Apr 27; 107 (107; 17; 2010 Apr 27):7999-8004. [Full Text/Abstract]
    Jeon J, Dencker D, Wörtwein G, Woldbye DP, Cui Y, Davis AA, Levey AI, Schütz G, Sager TN, Mørk A, Li C, Deng CX, Fink-Jensen A, Wess J. A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neurosci. 2010 Feb 10; 30 (6; 30; 2010 Feb 10):2396-405. [Full Text/Abstract]
    Guettier JM, Gautam D, Scarselli M, Ruiz de Azua I, Li JH, Rosemond E, Ma X, Gonzalez FJ, Armbruster BN, Lu H, Roth BL, Wess J. A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc Natl Acad Sci U S A. 2009 Nov 10; 106 (106; 2009 Nov 10; 45):19197-202. [Full Text/Abstract]
    Li JH, Chou CL, Li B, Gavrilova O, Eisner C, Schnermann J, Anderson SA, Deng CX, Knepper MA, Wess J. A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. J Clin Invest. 2009 Oct; 119 (2009 Oct; 119; 10):3115-26. [Full Text/Abstract]
    Gautam D, Jeon J, Starost MF, Han SJ, Hamdan FF, Cui Y, Parlow AF, Gavrilova O, Szalayova I, Mezey E, Wess J. Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proc Natl Acad Sci U S A. 2009 Apr 14; 106 (106; 2009 Apr 14; 15):6398-403. [Full Text/Abstract]
    Wess J, Han SJ, Kim SK, Jacobson KA, Li JH. Conformational changes involved in G-protein-coupled-receptor activation. Trends Pharmacol Sci. 2008 Dec; 29 (2008 Dec; 12; 29):616-25. [Full Text/Abstract]
    Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008 Aug; 5 (8; 2008 Aug; 5):673-8. [Full Text/Abstract]
    Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE, Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008 Jan; 4 (2008 Jan; 4; 1):42-50. [Full Text/Abstract]
    Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov. 2007 Sep; 6 (6; 9; 2007 Sep):721-33. [Full Text/Abstract]
    Li B, Scarselli M, Knudsen CD, Kim SK, Jacobson KA, McMillin SM, Wess J. Rapid identification of functionally critical amino acids in a G protein-coupled receptor. Nat Methods. 2007 Feb; 4 (2; 4; 2007 Feb):169-74. [Full Text/Abstract]
    Gautam D, Gavrilova O, Jeon J, Pack S, Jou W, Cui Y, Li JH, Wess J. Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency. Cell Metab. 2006 Nov; 4 (4; 5; 2006 Nov):363-75. [Full Text/Abstract]
    Gautam D, Han SJ, Hamdan FF, Jeon J, Li B, Li JH, Cui Y, Mears D, Lu H, Deng C, Heard T, Wess J. A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab. 2006 Jun; 3 (6; 2006 Jun; 3):449-61. [Full Text/Abstract]
    Seeger T, Fedorova I, Zheng F, Miyakawa T, Koustova E, Gomeza J, Basile AS, Alzheimer C, Wess J. M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity. J Neurosci. 2004 Nov 10; 24 (2004 Nov 10; 45; 24):10117-27. [Full Text/Abstract]
    Duttaroy A, Zimliki CL, Gautam D, Cui Y, Mears D, Wess J. Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes. 2004 Jul; 53 (2004 Jul; 7; 53):1714-20. [Full Text/Abstract]