U.S. Department of Health and Human Services
Jurrien Dean

 Contact Info

Tel: 301-496-2738
Email: jurriend@helix.nih.gov

 Select Experience

  • M.D.College of Physicians and Surgeons, Columbia University1973
  • B.A.Columbia College, Columbia University1969

 Related Links

  • Cell Biology/Cell Signaling
  • Developmental Biology
  • Molecular Biology/Biochemistry


A selection of recent and significant publications can be viewed below.

Avella MA, Baibakov B, Dean J. A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans. J Cell Biol. 2014 Jun 23; 205:801-9. [Full Text/Abstract]
Baibakov B, Boggs NA, Yauger B, Baibakov G, Dean J. Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice. J. Cell Biol. 2012 Jun 25; 197:897-905. [Full Text/Abstract]
Burkart AD, Xiong B, Baibakov B, Jiménez-Movilla M, Dean J. Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. J. Cell Biol. 2012 Apr 2; 197:37-44. [Full Text/Abstract]
Avella MA, Dean J. Fertilization with acrosome-reacted mouse sperm: implications for the site of exocytosis. Proc. Natl. Acad. Sci. U.S.A. 2011 Dec 13; 108:19843-4. [Full Text/Abstract]
Jimenez-Movilla M, Dean J. ZP2 and ZP3 cytoplasmic tails prevent premature interactions and ensure incorporation into the zona pellucida. J. Cell. Sci. 2011 Mar 15; 124:940-50. [Full Text/Abstract]
Yauger B, Boggs NA, Dean J. Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice. Reproduction. 2011 Mar; 141:313-9. [Full Text/Abstract]
Gahlay G, Gauthier L, Baibakov B, Epifano O, Dean J. Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein. Science. 2010 Jul 9; 329:216-9. [Full Text/Abstract]
Hu W, Gauthier L, Baibakov B, Jimenez-Movilla M, Dean J. FIGLA, a basic helix-loop-helix transcription factor, balances sexually dimorphic gene expression in postnatal oocytes. Mol. Cell. Biol. 2010 Jul; 30:3661-71. [Full Text/Abstract]
Li L, Zheng P, Dean J. Maternal control of early mouse development. Development. 2010 Mar; 137:859-70. [Full Text/Abstract]
Zheng P, Dean J. Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 2009 May 5; 106:7473-8. [Full Text/Abstract]
Li L, Baibakov B, Dean J. A subcortical maternal complex essential for preimplantation mouse embryogenesis. Dev. Cell. 2008 Sep; 15:416-25. [Full Text/Abstract]
Ohsugi M, Zheng P, Baibakov B, Li L, Dean J. Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos. Development. 2008 Jan; 135:259-69. [Full Text/Abstract]
Zheng P, Dean J. Oocyte-specific genes affect folliculogenesis, fertilization, and early development. Semin. Reprod. Med. 2007 Jul; 25:243-51. [Full Text/Abstract]
Joshi S, Davies H, Sims LP, Levy SE, Dean J. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. BMC Dev. Biol. 2007 Jun 13; 7:67. [Full Text/Abstract]
Baibakov B, Gauthier L, Talbot P, Rankin TL, Dean J. Sperm binding to the zona pellucida is not sufficient to induce acrosome exocytosis. Development. 2007 Mar; 134:933-43. [Full Text/Abstract]
Hoodbhoy T, Avilés M, Baibakov B, Epifano O, Jiménez-Movilla M, Gauthier L, Dean J. ZP2 and ZP3 traffic independently within oocytes prior to assembly into the extracellular zona pellucida. Mol. Cell. Biol. 2006 Nov; 26:7991-8. [Full Text/Abstract]