U.S. Department of Health and Human Services
Jurrien Dean
 

 Contact Info

 
Tel: 301-496-2738
Email: jurriend@helix.nih.gov
 

 Select Experience

 
  • M.D.College of Physicians and Surgeons, Columbia University1973
  • B.A.Columbia College, Columbia University1969
 

 Related Links

 
Specialties
  • Cell Biology/Cell Signaling
  • Developmental Biology
  • Molecular Biology/Biochemistry

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Avella MA, Baibakov B, Dean J. A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans. J Cell Biol. 2014 Jun 23; 205 (2014 Jun 23; 6; 205):801-9. [Full Text/Abstract]
Li L, Lu X, Dean J. The maternal to zygotic transition in mammals. Mol Aspects Med. 2013 Oct; 34 (2013 Oct; 5; 34):919-38. [Full Text/Abstract]
Avella MA, Xiong B, Dean J. The molecular basis of gamete recognition in mice and humans. Mol Hum Reprod. 2013 May; 19 (2013 May; 19; 5):279-89. [Full Text/Abstract]
Baibakov B, Boggs NA, Yauger B, Baibakov G, Dean J. Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice. J Cell Biol. 2012 Jun 25; 197 (2012 Jun 25; 197; 7):897-905. [Full Text/Abstract]
Burkart AD, Xiong B, Baibakov B, Jiménez-Movilla M, Dean J. Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. J Cell Biol. 2012 Apr 2; 197 (197; 2012 Apr 2; 1):37-44. [Full Text/Abstract]
Avella MA, Dean J. Fertilization with acrosome-reacted mouse sperm: implications for the site of exocytosis. Proc Natl Acad Sci U S A. 2011 Dec 13; 108 (108; 50; 2011 Dec 13):19843-4. [Full Text/Abstract]
Jimenez-Movilla M, Dean J. ZP2 and ZP3 cytoplasmic tails prevent premature interactions and ensure incorporation into the zona pellucida. J Cell Sci. 2011 Mar 15; 124 (124; Pt 6; 2011 Mar 15):940-50. [Full Text/Abstract]
Yauger B, Boggs NA, Dean J. Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice. Reproduction. 2011 Mar; 141 (2011 Mar; 141; 3):313-9. [Full Text/Abstract]
Gahlay G, Gauthier L, Baibakov B, Epifano O, Dean J. Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein. Science. 2010 Jul 9; 329 (329; 5988; 2010 Jul 9):216-9. [Full Text/Abstract]
Hu W, Gauthier L, Baibakov B, Jimenez-Movilla M, Dean J. FIGLA, a basic helix-loop-helix transcription factor, balances sexually dimorphic gene expression in postnatal oocytes. Mol Cell Biol. 2010 Jul; 30 (30; 14; 2010 Jul):3661-71. [Full Text/Abstract]
Zheng P, Dean J. Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Proc Natl Acad Sci U S A. 2009 May 5; 106 (106; 2009 May 5; 18):7473-8. [Full Text/Abstract]
Li L, Baibakov B, Dean J. A subcortical maternal complex essential for preimplantation mouse embryogenesis. Dev Cell. 2008 Sep; 15 (15; 3; 2008 Sep):416-25. [Full Text/Abstract]
Ohsugi M, Zheng P, Baibakov B, Li L, Dean J. Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos. Development. 2008 Jan; 135 (2008 Jan; 2; 135):259-69. [Full Text/Abstract]
Baibakov B, Gauthier L, Talbot P, Rankin TL, Dean J. Sperm binding to the zona pellucida is not sufficient to induce acrosome exocytosis. Development. 2007 Mar; 134 (134; 5; 2007 Mar):933-43. [Full Text/Abstract]
Hoodbhoy T, Avilés M, Baibakov B, Epifano O, Jiménez-Movilla M, Gauthier L, Dean J. ZP2 and ZP3 traffic independently within oocytes prior to assembly into the extracellular zona pellucida. Mol Cell Biol. 2006 Nov; 26 (21; 26; 2006 Nov):7991-8. [Full Text/Abstract]
Hoodbhoy T, Joshi S, Boja ES, Williams SA, Stanley P, Dean J. Human sperm do not bind to rat zonae pellucidae despite the presence of four homologous glycoproteins. J Biol Chem. 2005 Apr 1; 280 (280; 13; 2005 Apr 1):12721-31. [Full Text/Abstract]
Zhao M, Gold L, Dorward H, Liang LF, Hoodbhoy T, Boja E, Fales HM, Dean J. Mutation of a conserved hydrophobic patch prevents incorporation of ZP3 into the zona pellucida surrounding mouse eggs. Mol Cell Biol. 2003 Dec; 23 (2003 Dec; 23; 24):8982-91. [Full Text/Abstract]
Boja ES, Hoodbhoy T, Fales HM, Dean J. Structural characterization of native mouse zona pellucida proteins using mass spectrometry. J Biol Chem. 2003 Sep 5; 278 (2003 Sep 5; 278; 36):34189-202. [Full Text/Abstract]
Rankin TL, Coleman JS, Epifano O, Hoodbhoy T, Turner SG, Castle PE, Lee E, Gore-Langton R, Dean J. Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs. Dev Cell. 2003 Jul; 5 (2003 Jul; 5; 1):33-43. [Full Text/Abstract]
Zhao M, Gold L, Ginsberg AM, Liang LF, Dean J. Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. Mol Cell Biol. 2002 May; 22 (2002 May; 9; 22):3111-20. [Full Text/Abstract]
Takasaki N, Rankin T, Dean J. Normal gonadal development in mice lacking GPBOX, a homeobox protein expressed in germ cells at the onset of sexual dimorphism. Mol Cell Biol. 2001 Dec; 21 (2001 Dec; 23; 21):8197-202. [Full Text/Abstract]
Rankin TL, O'Brien M, Lee E, Wigglesworth K, Eppig J, Dean J. Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development. Development. 2001 Apr; 128 (128; 2001 Apr; 7):1119-26. [Full Text/Abstract]
Tong ZB, Gold L, Pfeifer KE, Dorward H, Lee E, Bondy CA, Dean J, Nelson LM. Mater, a maternal effect gene required for early embryonic development in mice. Nat Genet. 2000 Nov; 26 (2000 Nov; 3; 26):267-8. [Full Text/Abstract]
Soyal SM, Amleh A, Dean J. FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation. Development. 2000 Nov; 127 (127; 2000 Nov; 21):4645-54. [Full Text/Abstract]
Takasaki N, McIsaac R, Dean J. Gpbox (Psx2), a homeobox gene preferentially expressed in female germ cells at the onset of sexual dimorphism in mice. Dev Biol. 2000 Jul 1; 223 (2000 Jul 1; 1; 223):181-93. [Full Text/Abstract]
Rankin T, Talbot P, Lee E, Dean J. Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss. Development. 1999 Sep; 126 (126; 17; 1999 Sep):3847-55. [Full Text/Abstract]
Greenhouse S, Castle PE, Dean J. Antibodies to human ZP3 induce reversible contraception in transgenic mice with 'humanized' zonae pellucidae. Hum Reprod. 1999 Mar; 14 (1999 Mar; 14; 3):593-600. [Full Text/Abstract]
Rankin TL, Tong ZB, Castle PE, Lee E, Gore-Langton R, Nelson LM, Dean J. Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding. Development. 1998 Jul; 125 (13; 1998 Jul; 125):2415-24. [Full Text/Abstract]
Liang L, Soyal SM, Dean J. FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development. 1997 Dec; 124 (124; 1997 Dec; 24):4939-47. [Full Text/Abstract]
Rankin T, Familari M, Lee E, Ginsberg A, Dwyer N, Blanchette-Mackie J, Drago J, Westphal H, Dean J. Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development. 1996 Sep; 122 (122; 1996 Sep; 9):2903-10. [Full Text/Abstract]