U.S. Department of Health and Human Services
Kai Ge
 

 Contact Info

 
Tel: 301-451-1998
Email: kai.ge@nih.gov
 

 Select Experience

 
  • Postdoctoral FellowThe Rockefeller University2000–2003
  • Postdoctoral FellowThe Wistar Institute1997–2000
  • Ph.D.Shanghai Institute of Biochemistry, Chinese Academy of Sciences1997
  • B.S.Fudan University1992
 

 Related Links

 

    Specialties
    • Cell Biology/Cell Signaling
    • Chromosome Biology/Epigenetics
    • Developmental Biology
    • Genetics/Genomics
    • Molecular Biology/Biochemistry
    • Stem Cells/Induced Pluripotent Stem Cells
    • Systems Biology

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W, Ge K. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. Elife. 2013; 2:e01503. [Full Text/Abstract]
    Wang L, Xu S, Lee JE, Baldridge A, Grullon S, Peng W, Ge K. Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis. EMBO J. 2013 Jan 9; 32:45-59. [Full Text/Abstract]
    Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc. Natl. Acad. Sci. U.S.A. 2012 Sep 18; 109:15324-9. [Full Text/Abstract]
    Ge K. Epigenetic regulation of adipogenesis by histone methylation. Biochim. Biophys. Acta. 2012 Jul; 1819:727-32. [Full Text/Abstract]
    Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J. 2011 Jan 19; 30:249-62. [Full Text/Abstract]
    Seenundun S, Rampalli S, Liu QC, Aziz A, Palii C, Hong S, Blais A, Brand M, Ge K, Dilworth FJ. UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J. 2010 Apr 21; 29:1401-11. [Full Text/Abstract]
    Wang L, Jin Q, Lee JE, Su IH, Ge K. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 2010 Apr 20; 107:7317-22. [Full Text/Abstract]
    Cho YW, Hong S, Jin Q, Wang L, Lee JE, Gavrilova O, Ge K. Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab. 2009 Jul; 10:27-39. [Full Text/Abstract]
    Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J. Biol. Chem. 2009 Mar 13; 284:7284-93. [Full Text/Abstract]
    Ge K, Cho YW, Guo H, Hong TB, Guermah M, Ito M, Yu H, Kalkum M, Roeder RG. Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol. Cell. Biol. 2008 Feb; 28:1081-91. [Full Text/Abstract]
    Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc. Natl. Acad. Sci. U.S.A. 2007 Nov 20; 104:18439-44. [Full Text/Abstract]
    Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 2007 Jul 13; 282:20395-406. [Full Text/Abstract]
    Guermah M, Ge K, Chiang CM, Roeder RG. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol. Cell. 2003 Oct; 12:991-1001. [Full Text/Abstract]
    Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature. 2002 May 30; 417:563-7. [Full Text/Abstract]
    Cho YW, Hong S, Ge K. Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex. Methods Mol. Biol. 2012; 809:465-72. [Full Text/Abstract]