U.S. Department of Health and Human Services
Karen Usdin
 

 Contact Info

 
Tel: 301-496-2189
Email: karenu@helix.nih.gov
 

 Select Experience

 
  • Ph.D.University of Cape Town1986
 

 Related Links

 

    Karen Usdin, Ph.D.

    Senior Investigator, Laboratory of Cell and Molecular Biology, Office of the Chief
    Specialties
    • ¬†Stem Cells/Induced Pluripotent Stem Cells
    • Chromosome Biology/Epigenetics
    • Genetics/Genomics
    • Molecular Biology/Biochemistry

    ‚ÄčPublications

    A selection of recent and significant publications can be viewed below.

    Publications
    Iliff AJ, Renoux AJ, Krans A, Usdin K, Sutton MA, Todd PK. Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice. Hum. Mol. Genet. 2013 Mar 15; 22:1180-92. [Full Text/Abstract]
    Lokanga RA, Entezam A, Kumari D, Yudkin D, Qin M, Smith CB, Usdin K. Somatic expansion in mouse and human carriers of fragile X premutation alleles. Hum. Mutat. 2013 Jan; 34:157-66. [Full Text/Abstract]
    Kumari D, Lokanga R, Yudkin D, Zhao XN, Usdin K. Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia. Biochim. Biophys. Acta. 2012 Jul; 1819:802-10. [Full Text/Abstract]
    Hoffman GE, Le WW, Entezam A, Otsuka N, Tong ZB, Nelson L, Flaws JA, McDonald JH, Jafar S, Usdin K. Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency. J. Histochem. Cytochem. 2012 Jun; 60:439-56. [Full Text/Abstract]
    Kumari D, Usdin K. Is Friedreich ataxia an epigenetic disorder? Clin Epigenetics. 2012 Jan 30; 4:2. [Full Text/Abstract]
    Qin M, Entezam A, Usdin K, Huang T, Liu ZH, Hoffman GE, Smith CB. A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis. Neurobiol. Dis. 2011 Apr; 42:85-98. [Full Text/Abstract]
    Kumari D, Biacsi RE, Usdin K. Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells. J. Biol. Chem. 2011 Feb 11; 286:4209-15. [Full Text/Abstract]
    Kumari D, Usdin K. The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome. Hum. Mol. Genet. 2010 Dec 1; 19:4634-42. [Full Text/Abstract]
    Entezam A, Lokanga AR, Le W, Hoffman G, Usdin K. Potassium bromate, a potent DNA oxidizing agent, exacerbates germline repeat expansion in a fragile X premutation mouse model. Hum. Mutat. 2010 May; 31:611-6. [Full Text/Abstract]
    Entezam A, Usdin K. ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice. Nucleic Acids Res. 2009 Oct; 37:6371-7. [Full Text/Abstract]
    Kumari D, Somma V, Nakamura AJ, Bonner WM, D'Ambrosio E, Usdin K. The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome. Nucleic Acids Res. 2009 Jul; 37:4385-92. [Full Text/Abstract]
    Usdin K. The biological effects of simple tandem repeats: lessons from the repeat expansion diseases. Genome Res. 2008 Jul; 18:1011-9. [Full Text/Abstract]
    Biacsi R, Kumari D, Usdin K. SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. PLoS Genet. 2008 Mar 7; 4:e1000017. [Full Text/Abstract]
    Entezam A, Usdin K. ATR protects the genome against CGG.CCG-repeat expansion in Fragile X premutation mice. Nucleic Acids Res. 2008 Feb; 36:1050-6. [Full Text/Abstract]
    Entezam A, Biacsi R, Orrison B, Saha T, Hoffman GE, Grabczyk E, Nussbaum RL, Usdin K. Regional FMRP deficits and large repeat expansions into the full mutation range in a new Fragile X premutation mouse model. Gene. 2007 Jun 15; 395:125-34. [Full Text/Abstract]
    Mahishi L, Usdin K. NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2). Biochem. J. 2006 Dec 1; 400:327-35. [Full Text/Abstract]
    Handa V, Yeh HJ, McPhie P, Usdin K. The AUUCU repeats responsible for spinocerebellar ataxia type 10 form unusual RNA hairpins. J. Biol. Chem. 2005 Aug 12; 280:29340-5. [Full Text/Abstract]
    Handa V, Goldwater D, Stiles D, Cam M, Poy G, Kumari D, Usdin K. Long CGG-repeat tracts are toxic to human cells: implications for carriers of Fragile X premutation alleles. FEBS Lett. 2005 May 9; 579:2702-8. [Full Text/Abstract]
    Greene E, Entezam A, Kumari D, Usdin K. Ancient repeated DNA elements and the regulation of the human frataxin promoter. Genomics. 2005 Feb; 85:221-30. [Full Text/Abstract]
    Handa V, Saha T, Usdin K. The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by Dicer. Nucleic Acids Res. 2003 Nov 1; 31:6243-8. [Full Text/Abstract]
    Greene E, Mahishi L, Entezam A, Kumari D, Usdin K. Repeat-induced epigenetic changes in intron 1 of the frataxin gene and its consequences in Friedreich ataxia. Nucleic Acids Res. 2007; 35:3383-90. [Full Text/Abstract]