U.S. Department of Health and Human Services
Kenneth Jacobson
 

 Contact Info

 
Tel: +1 301 496 9024
Email: kajacobs@helix.nih.gov
 

 Training and Experience

 
Ph.D., University of California, San Diego, 1981

M.S., University of California, San Diego, 1978

B.A., Reed College, 1975

Bantrel Fellow, Weizmann Institute of Science, Department of Organic Chemistry, 1983
 

 Related Links

 
Specialties: Chemistry/Chemical Biology, Molecular Biology/Biochemistry,  Molecular Pharmacology/Toxicology

​Research Images

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TitleDescriptionImage
Morphing of the antagonist bound structure
Comparison of locked ring ribose analogues of nucleotides binding at adenosine and P2Y receptorsDepicted is a methanocarba ring as a ribose modifi cation in ligands of G protein-coupled purine and pyrimidine receptors.  Source: Tosh, D.K., Jacobson, K.A. Methanocarba ring as a ribose modification in ligands of G protein-coupled purine and pyrimidine receptors: Synthetic approaches. Med. Chem. Comm., 2013, 4:619-630Comparison of locked ring ribose analogues of nucleotides binding at adenosine and P2Y receptorsEnlarge
Molecular model of a homodimeric A2A adenosine receptorDepicted is a molecular model of a homodimeric A2A adenosine receptor containing a bound conjugate of a PAMAM (polyamidoamine) dendrimer and an A2A agonist, CGS21680.  In this model, the multivalent dendrimer conjugate is able to bridge both binding sites of the dimeric receptor.   Bioorg. Med. Chem. Lett., 2008, 18:4312-4315Molecular model of a homodimeric A2A adenosine receptorEnlarge
The newly determined structure of the A2A receptor for adenosineThe newly determined structure of the A2A receptor for adenosine is shown surrounding its synthetic agonist.The newly determined structure of the A2A receptor for adenosineEnlarge
Engineering of Selective Ligands for Mechanistic ProbingEngineering of selective ligands for mechanistic probing and therapeutic modulation of adenosine and P2Y nucleotide receptors.Engineering of Selective Ligands for Mechanistic ProbingEnlarge