All these studies are aimed to improve our understanding of normal human physiology and diseases, such as obesity.
My laboratory focuses on human energy metabolism as it relates to health and disease. We have developed several whole-room indirect calorimeters, also called respiration or metabolic chambers, which we use to measure the rate of energy expenditure at the minute-by-minute level and substrate oxidation for several hours or for several days. We can also simultaneously measure movement and physiological parameters in this well-controlled environment to study the impacts of physical activities, diets, medications, and environmental temperatures on energy metabolism, heart rate, and hormonal responses. We are also developing new technologies for measuring body composition and physical activity in humans.
Applying our Research
The obesity epidemic has increased the general interests in metabolism and diet. By studying both normal healthy volunteers and patients who are obese or have other metabolic conditions, we can better understand how our metabolism is regulated. This may lead to better treatment and prevention strategies.
Need for Further Study
The metabolic responses to common environmental stimuli, as simple as room temperature, and how individuals are different, are not well understood.