U.S. Department of Health and Human Services
Jake Liang

 Contact Info

Tel: 301-496-1721
Email: jakel@mail.nih.gov

 Select Experience

  • M.D.Harvard Medical School1984
  • B.A.Harvard College1980

 Related Links


    • Clinical Research
    • Genetics/Genomics
    • Immunology
    • Stem Cells/Induced Pluripotent Stem Cells
    • Virology

    ​Research Images

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    3-D structure of HCVThe three-dimensional structure of HCV is visualized and simulated by using electron cryomicroscopy of recombinant HCV-like viral particles.3-D structure of HCVEnlarge
    iPSC-derived human hepatocytesHuman hepatocytes, generated from induced pluripotent stem cells derived from a patient, produce and exhibit hepatocyte-specific proteins (albumin) and functions (lipid and glycogen storage, organic anion transport).  This regenerative medicine technology can be a valuable strategy for cell-based therapy of liver diseases.iPSC-derived human hepatocytesEnlarge
    Induction of steatosis by HCVHCV infection of human hepatocyte-derived cells induces a lipogenic program that results in massive accumulation of lipid droplets (green and yellow structures).  This is known as steatosis and is essential for HCV propagation.Induction of steatosis by HCVEnlarge