U.S. Department of Health and Human Services
Lothar Hennighausen

 Contact Info

Tel: +1 301 496 2716
Email: lotharh@helix.nih.gov

 Training and Experience

Ph.D., University of Cologne, 1982

M.S., University of Cologne, 1979

B.S., Philipp University of Marburg, 1977

 Related Links

Specialties: Genetics/Genomics, Molecular Biology/Biochemistry, Cell Biology/Cell Signaling, Computational Biology/Bioinformatics/Biostatistics/Mathematics, Developmental Biology, Mammary Gland Biology


A selection of recent and significant publications can be viewed below.

Yamaji D, Kang K, Robinson GW, Hennighausen L. Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration. Nucleic Acids Res. 2013 Feb 1; 41 (2013 Feb 1; 41; 3):1622-36. [Full Text/Abstract]
Kang K, Robinson GW, Hennighausen L. Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules. BMC Genomics. 2013 Jan 16; 14 (14; 2013 Jan 16):4. [Full Text/Abstract]
Yu JH, Zhu BM, Riedlinger G, Kang K, Hennighausen L. The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice. Hepatology. 2012 Dec; 56 (2012 Dec; 56; 6):2375-86. [Full Text/Abstract]
Zhu BM, Kang K, Yu JH, Chen W, Smith HE, Lee D, Sun HW, Wei L, Hennighausen L. Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes. Nucleic Acids Res. 2012 May; 40 (40; 2012 May; 10):4461-72. [Full Text/Abstract]
Klover PJ, Muller WJ, Robinson GW, Pfeiffer RM, Yamaji D, Hennighausen L. Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden. Neoplasia. 2010 Nov; 12 (2010 Nov; 12; 11):899-905. [Full Text/Abstract]
Yu JH, Zhu BM, Wickre M, Riedlinger G, Chen W, Hosui A, Robinson GW, Hennighausen L. The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression. Hepatology. 2010 Nov; 52 (2010 Nov; 5; 52):1808-18. [Full Text/Abstract]
Kimura A, Martin C, Robinson GW, Simone JM, Chen W, Wickre MC, O'Shea JJ, Hennighausen L. The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B. J. Biol. Chem. 2010 Oct 22; 285 (2010 Oct 22; 43; 285):32704-9. [Full Text/Abstract]
Yamaji D, Na R, Feuermann Y, Pechhold S, Chen W, Robinson GW, Hennighausen L. Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. Genes Dev. 2009 Oct 15; 23 (2009 Oct 15; 20; 23):2382-7. [Full Text/Abstract]
Zhu BM, McLaughlin SK, Na R, Liu J, Cui Y, Martin C, Kimura A, Robinson GW, Andrews NC, Hennighausen L. Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood. 2008 Sep 1; 112 (5; 112; 2008 Sep 1):2071-80. [Full Text/Abstract]
Hennighausen L, Robinson GW. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev. 2008 Mar 15; 22 (6; 2008 Mar 15; 22):711-21. [Full Text/Abstract]
Cui Y, Hosui A, Sun R, Shen K, Gavrilova O, Chen W, Cam MC, Gao B, Robinson GW, Hennighausen L. Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology. 2007 Aug; 46 (46; 2007 Aug; 2):504-13. [Full Text/Abstract]
Hennighausen L, Robinson GW. Information networks in the mammary gland. Nat. Rev. Mol. Cell Biol. 2005 Sep; 6 (6; 9; 2005 Sep):715-25. [Full Text/Abstract]
Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, Deng CX, Robinson GW, Hennighausen L. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol. Cell. Biol. 2004 Sep; 24 (24; 18; 2004 Sep):8037-47. [Full Text/Abstract]
Shillingford JM, Miyoshi K, Robinson GW, Grimm SL, Rosen JM, Neubauer H, Pfeffer K, Hennighausen L. Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium. Mol. Endocrinol. 2002 Mar; 16 (16; 2002 Mar; 3):563-70. [Full Text/Abstract]