U.S. Department of Health and Human Services
Lothar Hennighausen

 Contact Info

Tel: +1 301 496 2716
Email: lotharh@helix.nih.gov

 Training and Experience

Ph.D., University of Cologne, 1982

M.S., University of Cologne, 1979

B.S., Philipp University of Marburg, 1977

 Related Links

Specialties: Genetics/Genomics, Molecular Biology/Biochemistry, Cell Biology/Cell Signaling, Computational Biology/Bioinformatics/Biostatistics/Mathematics, Developmental Biology, Mammary Gland Biology


Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.

Resource Name Description
Animal Models to Study Mammary Gland Development, Physiology, and Tumorigenesis

A guide to animal models which have been used to study molecular mechanisms of Mammary Gland Development, Physiology and Tumorigenesis.

Stat5a KO(Stat5a tm1Mam) Mouse (Mutant Mouse: Stat 5a (Signal transducer and activator of transcription))

Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis.


Prolactin induces mammary gland development and … (Summary)

Bcl-x LoxP (Bcl2l1 tm1.1Mam) Mouse (Mutant Mouse: Bcl2l1(Bcl2-like 1))

Floxed Bcl-x: Conditional knockout of pro-survival Bcl-x in primordial germ cells was used to study the balance between pro-aptoptotic Bax during embryogenesis.

Bcl-x is a pro-survival … (Summary)

Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5b tm2Mam) Mouse (Mutant Mouse: Stat5a/b)

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions.


The … (Summary)

Tg(MMTV-Cre)#Mam Mouse (Mutant Mouse: MMTV-Cre (Mammary tumor virus long terminal repeat-Cre recombinase))

Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination … (Summary)

Tg(Wap-cre)11738Mam Mouse (Mutant Mouse: WAP-Cre (whey acidic protein promoter directs Cre recombinase))

Cre-recombinase under the control of the whey acidic acid protein was only detected in alveolar epithelial epithelial cells of mammary tissue during lactation, and transcription occurred at … (Summary)

Stat1LoxP (Stat1 tm1Mam) Mouse (Mutant Mouse: Stat1)

Selective inactivation of Stat 1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct.


STAT1 is considered a tumor suppressor, but it is not … (Summary)

View Additional Research Resources

Clinical Trials

Open studies conducted by NIDDK Principal Investigators appear below that are currently recruiting, not yet recruiting, or available for expanded access.

Study Title
There are no associated clinical trials.
Search for more clinical trials at ClinicalTrials.gov