U.S. Department of Health and Human Services
Marc Reitman

 Contact Info

Tel: 301-496-6442
Email: marc.reitman@nih.gov

 Select Experience

  • Senior Investigator and Branch ChiefNIDDK, NIH2011-present
  • Director, Clinical Research; Director Obesity and Metabolic ResearchMerck Research Laboratories2002-2011
  • Fellow; Investigator; Senior InvestigatorNIDDK, NIH1986-2002
  • Residency in Internal MedicineColumbia-Presbyterian Hospital1983-1986
  • M.D., Ph.D.Washington University1983
  • B.S.Massachusetts Institute of Technology1977

 Related Links

  • Clinical Research
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Molecular Pharmacology/Toxicology
  • Neuroscience/Neurophysiology/Neurodevelopment


A selection of recent and significant publications can be viewed below.

Xiao C, Goldgof M, Gavrilova O, Reitman ML. Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C. Obesity (Silver Spring). 2015 Jun 5; 23 (2015 Jun 5; 23; 7):1450-1459. [Full Text/Abstract]
Abreu-Vieira G, Xiao C, Gavrilova O, Reitman ML. Integration of body temperature into the analysis of energy expenditure in the mouse. Mol Metab. 2015 Jun; 4 (6; 4; 2015 Jun):461-70. [Full Text/Abstract]
Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC. RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals. J Clin Endocrinol Metab. 2015 Feb 12; 100 (100; 2015 Feb 12; 4):1639-1645. [Full Text/Abstract]
Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML. Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014 Aug 5; 20 (20; 2014 Aug 5; 2):333-45. [Full Text/Abstract]
Goldgof M, Xiao C, Chanturiya T, Jou W, Gavrilova O, Reitman ML. The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects Against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality. J Biol Chem. 2014 Jul 11; 289 (28; 2014 Jul 11; 289):19341-50. [Full Text/Abstract]
Lateef DM, Abreu-Vieira G, Xiao C, Reitman ML. Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3. Am J Physiol Endocrinol Metab. 2014 Mar; 306 (2014 Mar; 6; 306):E681-7. [Full Text/Abstract]
Ravussin Y, Xiao C, Gavrilova O, Reitman ML. Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. PLoS One. 2014; 9 (2014; 9; 1):e85876. [Full Text/Abstract]
Reitman ML. FGF21 Mimetic Shows Therapeutic Promise. Cell Metab. 2013 Sep 3; 18 (2013 Sep 3; 3; 18):307-9. [Full Text/Abstract]
Reitman ML, Dishy V, Moreau A, Denney WS, Liu C, Kraft WK, Mejia AV, Matson MA, Stoch SA, Wagner JA, Lai E. Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patients. J Clin Pharmacol. 2012 Sep; 52 (2012 Sep; 9; 52):1306-16. [Full Text/Abstract]
Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV Jr, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28; 9 (9; 1; 2011 Dec 28):57-63. [Full Text/Abstract]
Feng Y, Guan XM, Li J, Metzger JM, Zhu Y, Juhl K, Zhang BB, Thornberry NA, Reitman ML, Zhou YP. Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species. Endocrinology. 2011 Nov; 152 (2011 Nov; 152; 11):4106-15. [Full Text/Abstract]
Guan XM, Metzger JM, Yang L, Raustad KA, Wang SP, Spann SK, Kosinski JA, Yu H, Shearman LP, Faidley TD, Palyha O, Kan Y, Kelly TM, Sebhat I, Lin LS, Dragovic J, Lyons KA, Craw S, Nargund RP, Marsh DJ, Strack AM, Reitman ML. Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist. J Pharmacol Exp Ther. 2011 Feb; 336 (2; 2011 Feb; 336):356-64. [Full Text/Abstract]
Reitman ML, Chu X, Cai X, Yabut J, Venkatasubramanian R, Zajic S, Stone JA, Ding Y, Witter R, Gibson C, Roupe K, Evers R, Wagner JA, Stoch A. Rifampin's acute inhibitory and chronic inductive drug interactions: experimental and model-based approaches to drug-drug interaction trial design. Clin Pharmacol Ther. 2011 Feb; 89 (2; 2011 Feb; 89):234-42. [Full Text/Abstract]
Sebhat IK, Franklin C, Lo MM, Chen D, Jewell JP, Miller R, Pang J, Palyha O, Kan Y, Kelly TM, Guan XM, Marsh DJ, Kosinski JA, Metzger JM, Lyons K, Dragovic J, Guzzo PR, Henderson AJ, Reitman ML, Nargund RP, Wyvratt MJ, Lin LS. Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2011 Jan 13; 2 (2; 2011 Jan 13; 1):43-7. [Full Text/Abstract]
Metzger JM, Gagen K, Raustad KA, Yang L, White A, Wang SP, Craw S, Liu P, Lanza T, Lin LS, Nargund RP, Guan XM, Strack AM, Reitman ML. Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments. Am J Physiol Endocrinol Metab. 2010 Nov; 299 (2010 Nov; 299; 5):E816-24. [Full Text/Abstract]
Guan XM, Chen H, Dobbelaar PH, Dong Y, Fong TM, Gagen K, Gorski J, He S, Howard AD, Jian T, Jiang M, Kan Y, Kelly TM, Kosinski J, Lin LS, Liu J, Marsh DJ, Metzger JM, Miller R, Nargund RP, Palyha O, Shearman L, Shen Z, Stearns R, Strack AM, Stribling S, Tang YS, Wang SP, White A, Yu H, Reitman ML. Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity. Cell Metab. 2010 Feb 3; 11 (2010 Feb 3; 2; 11):101-12. [Full Text/Abstract]
Emilsson V, Thorleifsson G, Zhang B, Leonardson AS, Zink F, Zhu J, Carlson S, Helgason A, Walters GB, Gunnarsdottir S, Mouy M, Steinthorsdottir V, Eiriksdottir GH, Bjornsdottir G, Reynisdottir I, Gudbjartsson D, Helgadottir A, Jonasdottir A, Jonasdottir A, Styrkarsdottir U, Gretarsdottir S, Magnusson KP, Stefansson H, Fossdal R, Kristjansson K, Gislason HG, Stefansson T, Leifsson BG, Thorsteinsdottir U, Lamb JR, Gulcher JR, Reitman ML, Kong A, Schadt EE, Stefansson K. Genetics of gene expression and its effect on disease. Nature. 2008 Mar 27; 452 (2008 Mar 27; 7186; 452):423-8. [Full Text/Abstract]
Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem. 2003 Sep 5; 278 (2003 Sep 5; 278; 36):34268-76. [Full Text/Abstract]
Colombo C, Haluzik M, Cutson JJ, Dietz KR, Marcus-Samuels B, Vinson C, Gavrilova O, Reitman ML. Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearance. J Biol Chem. 2003 Feb 7; 278 (6; 2003 Feb 7; 278):3992-9. [Full Text/Abstract]
Reitman ML. Metabolic lessons from genetically lean mice. Annu Rev Nutr. 2002; 22 (2002; 22):459-82. [Full Text/Abstract]