Research conducted in my laboratory aims to determine optimal nutrition in health, disease, and treatment. Our research focuses on vitamin C (ascorbic acid) as a model nutrient. We determine how specific vitamin C functions relate to nutrient concentration in vitro and in vivo. We seek a functional basis for nutrient recommendations, rather than relying on preventing deficiency—the previous method used for many years. Facilitated glucose transporters mediate transport of the oxidation product of ascorbic acid, dehydroascorbic acid. Therefore, our work includes investigation of these transporters by themselves and in relation to dehydroascorbic acid.
Our laboratory conducts basic, translational, and clinical research in the following areas:
- ascorbic acid function in relation to concentration in cells and subcellular organelles
- mechanisms of ascorbic acid transport and accumulation
- ascorbic acid pharmacokinetics (dose-concentration relationships) in animals and people
- pharmacologic ascorbic acid as a prodrug for hydrogen peroxide formation in vivo and for treatment of cancer and infectious diseases
- ascorbic acid and free radical biology
- regulation of glucose transport in vitro and in vivo
- function of ascorbic acid in red blood cells in health and disease, with special attention to diabetes
Many countries base, in large part, recommended dietary allowances (RDAs) for vitamin C on this work.
Our research may benefit the public by providing new ways to: (1) prevent disease and optimize health through nutrition; (2) treat cancer with minimal side effects; (3) slow glucose absorption as an added treatment for obesity and diabetes; (4) prevent or delay complications of diabetes; and (5) improve the collection or storage of red blood cells for transfusion.