Our laboratory studies a process known as V(D)J recombination. This process puts together pieces of DNA to make a particular group of genes. These genes produce a variety of antibody proteins. Antibody proteins are critical to our immune system. They identify and destroy infections by bacteria and viruses.
This process breaks DNA molecules and rejoins them in many new combinations. These combinations allow us to fight off a large variety of infections. It works similarly to the way that the cell repairs damaged DNA. The common properties make studying V(D)J recombination a good way to examine DNA repair. We want to gain as much information about this process as possible and apply this knowledge to the immune system.