U.S. Department of Health and Human Services
Michael Krashes
 

 Contact Info

 
Tel: 301-827-0960
Email: michael.krashes@nih.gov
 

 Select Experience

 
  • Ph.D.University of Massachusetts Medical School2009
 

 Related Links

 

    Specialties
    • Neuroscience/Neurophysiology/Neurodevelopment

    ​Research Images

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    TitleDescriptionImage
    AgRP neurons of the arcuate nucleusThis image depicts AgRP (agouti-related peptide) neurons (magenta), critical drivers of hunger that sit at the base of the hypothalamus in the arcuate nucleus.  Given their anatomical position in the brain, they are in an ideal position to integrate signals from both brain and peripheral organs.  These neurons are both sufficient and necessary for mediating food intake.AgRP neurons of the arcuate nucleusEnlarge
    Pharmacogenetic activation of AgRP neurons
    Suppressing AgRP neurons abrogates hunger
    Excitatory afferent control of AgRP neuronsThis model summarizes the baroque nature of the AgRP hypothalamic feeding circuit.  Excitatory inputs from select orexigenic neurons in the paraventricular hypothalamus make monosynaptic connections to AgRP neurons and consequently orchestrate feeding behavior.  AgRP neurons then send inhibitory input back to a distinct anorexigenic neural population in the paraventricular hypothalamus.Excitatory afferent control of AgRP neuronsEnlarge