U.S. Department of Health and Human Services
Oksana Gavrilova
 

 Contact Info

 
Tel: 301-435-5370
Email: oksanag@intra.niddk.nih.gov
 

 Select Experience

 
  • Staff Scientist and Core DirectorMouse Metabolism Core Laboratory, NIDDK, NIH2002–Present
  • Staff ScientistDiabetes, Endocrinology, and Obesity Branch, NIDDK, NIH2000–2002
  • Visiting Research FellowDiabetes, Endocrinology, and Obesity Branch, NIDDK, NIH1994–2000
  • Research FellowUniversity of Texas Southwestern Medical Center1993–1994
  • Research ScientistInstitute of Genetics and Selection of Industrial Microorganisms 1987–1993
  • Ph.D.Institute of Genetics and Selection of Industrial Microorganisms1989
  • M.S.Moscow State University1983
 

 Related Links

 

    Oksana Gavrilova

    Director, Mouse Metabolism Core
    Specialties
    • Physiology and Metabolism

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    London E, Nesterova M, Sinaii N, Szarek E, Chanturiya T, Mastroyannis SA, Gavrilova O, Stratakis CA. Differentially Regulated Protein Kinase A (PKA) Activity in Adipose Tissue and Liver Is Associated With Resistance to Diet-Induced Obesity and Glucose Intolerance in Mice That Lack PKA Regulatory Subunit Type IIα. Endocrinology. 2014 Sep; 155 (155; 9; 2014 Sep):3397-408. [Full Text/Abstract]
    Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML. Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014 Aug 5; 20 (20; 2014 Aug 5; 2):333-45. [Full Text/Abstract]
    Goldgof M, Xiao C, Chanturiya T, Jou W, Gavrilova O, Reitman ML. The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects Against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality. J Biol Chem. 2014 Jul 11; 289 (28; 2014 Jul 11; 289):19341-50. [Full Text/Abstract]
    Alnaeeli M, Raaka BM, Gavrilova O, Teng R, Chanturiya T, Noguchi CT. Erythropoietin signaling: A novel regulator of white adipose tissue inflammation during diet-induced obesity. Diabetes. 2014 Jul; 63 (7; 63; 2014 Jul):2415-31. [Full Text/Abstract]
    Ravussin Y, Xiao C, Gavrilova O, Reitman ML. Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. PLoS One. 2014; 9 (2014; 9; 1):e85876. [Full Text/Abstract]
    Guo T, Bond ND, Jou W, Gavrilova O, Portas J, McPherron AC. Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy. Diabetes. 2012 Oct; 61 (2012 Oct; 10; 61):2414-23. [Full Text/Abstract]
    Chen M, Berger A, Kablan A, Zhang J, Gavrilova O, Weinstein LS. Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations. Endocrinology. 2012 Sep; 153 (153; 2012 Sep; 9):4256-65. [Full Text/Abstract]
    Shulzhenko N, Morgun A, Hsiao W, Battle M, Yao M, Gavrilova O, Orandle M, Mayer L, Macpherson AJ, McCoy KD, Fraser-Liggett C, Matzinger P. Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat Med. 2011 Nov 20; 17 (17; 2011 Nov 20; 12):1585-93. [Full Text/Abstract]
    Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, Mammen S, Yver DR, Cushman SW, Mueller E, Yamamoto M, Hsu LL, Noguchi CT. Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production. Nat Commun. 2011 Nov 1; 2 (2; 2011 Nov 1):520. [Full Text/Abstract]
    Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O, Deng CX. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest. 2011 Nov; 121 (2011 Nov; 121; 11):4477-90. [Full Text/Abstract]
    Kurima K, Hertzano R, Gavrilova O, Monahan K, Shpargel KB, Nadaraja G, Kawashima Y, Lee KY, Ito T, Higashi Y, Eisenman DJ, Strome SE, Griffith AJ. A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice. PLoS Genet. 2011 Sep; 7 (2011 Sep; 7; 9):e1002307. [Full Text/Abstract]
    Yadav H, Quijano C, Kamaraju AK, Gavrilova O, Malek R, Chen W, Zerfas P, Zhigang D, Wright EC, Stuelten C, Sun P, Lonning S, Skarulis M, Sumner AE, Finkel T, Rane SG. Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab. 2011 Jul 6; 14 (2011 Jul 6; 14; 1):67-79. [Full Text/Abstract]
    Chen M, Chen H, Nguyen A, Gupta D, Wang J, Lai EW, Pacak K, Gavrilova O, Quon MJ, Weinstein LS. G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis. Cell Metab. 2010 Apr 7; 11 (2010 Apr 7; 4; 11):320-30. [Full Text/Abstract]
    Cho YW, Hong S, Jin Q, Wang L, Lee JE, Gavrilova O, Ge K. Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab. 2009 Jul; 10 (2009 Jul; 10; 1):27-39. [Full Text/Abstract]
    Chen M, Wang J, Dickerson KE, Kelleher J, Xie T, Gupta D, Lai EW, Pacak K, Gavrilova O, Weinstein LS. Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. Cell Metab. 2009 Jun; 9 (6; 9; 2009 Jun):548-55. [Full Text/Abstract]
    Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS One. 2009; 4 (2009; 4; 3):e4937. [Full Text/Abstract]
    Bera TK, Liu XF, Yamada M, Gavrilova O, Mezey E, Tessarollo L, Anver M, Hahn Y, Lee B, Pastan I. A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proc Natl Acad Sci U S A. 2008 Jan 8; 105 (105; 2008 Jan 8; 1):270-5. [Full Text/Abstract]
    Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM. Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab. 2007 Feb; 5 (2; 5; 2007 Feb):115-28. [Full Text/Abstract]
    Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC. Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. J Clin Invest. 2006 Dec; 116 (2006 Dec; 116; 12):3240-51. [Full Text/Abstract]
    Gautam D, Gavrilova O, Jeon J, Pack S, Jou W, Cui Y, Li JH, Wess J. Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency. Cell Metab. 2006 Nov; 4 (4; 5; 2006 Nov):363-75. [Full Text/Abstract]
    Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem. 2003 Sep 5; 278 (2003 Sep 5; 278; 36):34268-76. [Full Text/Abstract]
    Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B Jr, Reitman ML, Gonzalez FJ. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest. 2003 Mar; 111 (111; 2003 Mar; 5):737-47. [Full Text/Abstract]