The primary objective of the Mouse Metabolism Core is to support research in the area of obesity and diabetes by providing standardized, high-quality phenotyping services for mouse models of diabetes, obesity, and related disorders. Our services include analysis of body composition and energy balance, euglycemic-hyperinsulinemic clamp, fatty acid oxidation in vivo and in isolated muscle, as well as isolation and transplantation of pancreatic islet. We also perform measurements of major metabolites and hormones in mouse serum and provide hands-on training in methods commonly used for analyses of energy and glucose metabolism in rodents.
In spite of the prevalence of obesity and diabetes in modern society, our understanding of their molecular basis is rudimentary. In particular, we need to learn more about the role of the central nervous system in the regulation of energy balance and glucose metabolism.